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Current Diabetes Reports
Erschienen in: Current Diabetes Reports 9/2016

01.09.2016 | Microvascular Complications—Neuropathy (R Pop-Busui, Section Editor)

Diabetes and Cognitive Impairment

verfasst von: Lindsay A. Zilliox, Krish Chadrasekaran, Justin Y. Kwan, James W. Russell

Erschienen in: Current Diabetes Reports | Ausgabe 9/2016

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Abstract

Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are further exacerbated by the metabolic syndrome. The duration of diabetes and glycemic control may have an impact on the type and severity of cognitive impairment, but as yet we cannot predict who is at greatest risk of developing cognitive impairment. The pathophysiology of cognitive impairment is multifactorial, although dysfunction in each interconnecting pathway ultimately leads to discordance in metabolic signaling. The pathophysiology includes defects in insulin signaling, autonomic function, neuroinflammatory pathways, mitochondrial (Mt) metabolism, the sirtuin-peroxisome proliferator-activated receptor-gamma co-activator 1α (SIRT-PGC-1α) axis, and Tau signaling. Several promising therapies have been identified in pre-clinical studies, but remain to be validated in clinical trials.
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Metadaten
Titel
Diabetes and Cognitive Impairment
verfasst von
Lindsay A. Zilliox
Krish Chadrasekaran
Justin Y. Kwan
James W. Russell
Publikationsdatum
01.09.2016
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 9/2016
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-016-0775-x

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