Diabetes and the Microvasculature of the Bone and Marrow
- 10.01.2024
- Verfasst von
- Teresa Le
- Amanda Salas Sanchez
- Danyah Nashawi
- Sunidhi Kulkarni
- Rhonda D. Prisby
- Erschienen in
- Current Osteoporosis Reports | Ausgabe 1/2024
Abstract
Purpose of Review
The purpose of this review is to highlight the evidence of microvascular dysfunction in bone and marrow and its relation to poor skeletal outcomes in diabetes mellitus.
Recent Findings
Diabetes mellitus is characterized by chronic hyperglycemia, which may lead to microangiopathy and macroangiopathy. Micro- and macroangiopathy have been diagnosed in Type 1 and Type 2 diabetes, coinciding with osteopenia, osteoporosis, enhanced fracture risk and delayed fracture healing. Microangiopathy has been reported in the skeleton, correlating with reduced blood flow and perfusion, vasomotor dysfunction, microvascular rarefaction, reduced angiogenic capabilities, and augmented vascular permeability.
Summary
Microangiopathy within the skeleton may be detrimental to bone and manifest as, among other clinical abnormalities, reduced mass, enhanced fracture risk, and delayed fracture healing. More investigations are required to elucidate the various mechanisms by which diabetic microvascular dysfunction impacts the skeleton.
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- Titel
- Diabetes and the Microvasculature of the Bone and Marrow
- Verfasst von
-
Teresa Le
Amanda Salas Sanchez
Danyah Nashawi
Sunidhi Kulkarni
Rhonda D. Prisby
- Publikationsdatum
- 10.01.2024
- Verlag
- Springer US
- Erschienen in
-
Current Osteoporosis Reports / Ausgabe 1/2024
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241 - DOI
- https://doi.org/10.1007/s11914-023-00841-3
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