Skip to main content
Erschienen in: Die Nephrologie 3/2020

08.04.2020 | Typ-2-Diabetes | Leitthema

Welche Dialysebehandlung bei diabetischer Nephropathie?

verfasst von: Prof. Dr. M. D. Alscher

Erschienen in: Die Nephrologie | Ausgabe 3/2020

Einloggen, um Zugang zu erhalten

Zusammenfassung

Weltweit nimmt der Diabetes Typ 2 zu. Korrespondierend finden sich auch mehr Patienten mit einer diabetischen Nephropathie. Kommt eine primäre, präemptive Nierentransplantation nicht in Betracht, muss eine Dialysebehandlung erfolgen. Vor einigen Jahren haben Leitlinien die Peritonealdialyse (PD) als Dialyseverfahren der Wahl für Diabetiker empfohlen. Dies wurde begründet durch ein besseres Überleben in den ersten Jahren der Behandlung, einen besseren Erhalt der Restnierenfunktion und weitere Faktoren wie Lebensqualität, Mobilität etc. Mittlerweile besteht die Empfehlung zu einer individualsierten Auswahl des Dialyseverfahrens, auch bei Diabetikern. Es ist trotzdem erstaunlich, dass die PD in Deutschland nur einen geringen Anteil hat. Bei aufgeklärten Patienten und freier Verfahrenswahl beträgt der PD-Anteil 30–50 %. Dies sollte auch bei Diabetikern angestrebt werden.
Literatur
1.
Zurück zum Zitat Adler AI, Stevens RJ, Manley SE et al (2003) Development and progression of nephropathy in type 2 diabetes: the United Kingdom prospective diabetes study (UKPDS 64). Kidney Int 63:225–232PubMedCrossRef Adler AI, Stevens RJ, Manley SE et al (2003) Development and progression of nephropathy in type 2 diabetes: the United Kingdom prospective diabetes study (UKPDS 64). Kidney Int 63:225–232PubMedCrossRef
3.
Zurück zum Zitat Braun N, Fritz P, Biegger D et al (2011) Difference in the expression of hormone receptors and fibrotic markers in the human peritoneum—implications for therapeutic targets to prevent encapsulating peritoneal sclerosis. Perit Dial Int 31:291–300PubMedCrossRef Braun N, Fritz P, Biegger D et al (2011) Difference in the expression of hormone receptors and fibrotic markers in the human peritoneum—implications for therapeutic targets to prevent encapsulating peritoneal sclerosis. Perit Dial Int 31:291–300PubMedCrossRef
4.
Zurück zum Zitat Bundesärztekammer (2020) Programm für Nationale Versorgungs Leitlinien. Ärztliches Zentrum für Qualität in der Medizin (ÄZQ) GbR, Berlin Bundesärztekammer (2020) Programm für Nationale Versorgungs Leitlinien. Ärztliches Zentrum für Qualität in der Medizin (ÄZQ) GbR, Berlin
5.
Zurück zum Zitat Cho Y, Johnson DW, Badve S et al (2013) Impact of icodextrin on clinical outcomes in peritoneal dialysis: a systematic review of randomized controlled trials. Nephrol Dial Transplant 28:1899–1907PubMedCrossRef Cho Y, Johnson DW, Badve S et al (2013) Impact of icodextrin on clinical outcomes in peritoneal dialysis: a systematic review of randomized controlled trials. Nephrol Dial Transplant 28:1899–1907PubMedCrossRef
6.
Zurück zum Zitat Chung SH, Noh H, Ha H et al (2009) Optimal use of peritoneal dialysis in patients with diabetes. Perit Dial Int 29(2):S132–134PubMedCrossRef Chung SH, Noh H, Ha H et al (2009) Optimal use of peritoneal dialysis in patients with diabetes. Perit Dial Int 29(2):S132–134PubMedCrossRef
7.
Zurück zum Zitat Cooper BA, Branley P, Bulfone L et al (2010) A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 363:609–619PubMedCrossRef Cooper BA, Branley P, Bulfone L et al (2010) A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 363:609–619PubMedCrossRef
8.
Zurück zum Zitat Couchoud C, Bolignano D, Nistor I et al (2015) Dialysis modality choice in diabetic patients with end-stage kidney disease: a systematic review of the available evidence. Nephrol Dial Transplant 30:310–320PubMedCrossRef Couchoud C, Bolignano D, Nistor I et al (2015) Dialysis modality choice in diabetic patients with end-stage kidney disease: a systematic review of the available evidence. Nephrol Dial Transplant 30:310–320PubMedCrossRef
9.
Zurück zum Zitat Davies SJ (2004) Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients. Kidney Int 66:2437–2445PubMedCrossRef Davies SJ (2004) Longitudinal relationship between solute transport and ultrafiltration capacity in peritoneal dialysis patients. Kidney Int 66:2437–2445PubMedCrossRef
10.
Zurück zum Zitat Ekart R, Hojs R (2016) Obese and diabetic patients with end-stage renal disease: peritoneal dialysis or hemodialysis? Eur J Intern Med 32:1–6PubMedCrossRef Ekart R, Hojs R (2016) Obese and diabetic patients with end-stage renal disease: peritoneal dialysis or hemodialysis? Eur J Intern Med 32:1–6PubMedCrossRef
12.
Zurück zum Zitat Giuliani A, Karopadi AN, Prieto-Velasco M et al (2017) Worldwide experiences with assisted peritoneal dialysis. Perit Dial Int 37:503–508PubMedCrossRef Giuliani A, Karopadi AN, Prieto-Velasco M et al (2017) Worldwide experiences with assisted peritoneal dialysis. Perit Dial Int 37:503–508PubMedCrossRef
14.
Zurück zum Zitat Jones M, Hagen T, Boyle CA et al (1998) Treatment of malnutrition with 1.1 % amino acid peritoneal dialysis solution: results of a multicenter outpatient study. Am J Kidney Dis 32:761–769PubMedCrossRef Jones M, Hagen T, Boyle CA et al (1998) Treatment of malnutrition with 1.1 % amino acid peritoneal dialysis solution: results of a multicenter outpatient study. Am J Kidney Dis 32:761–769PubMedCrossRef
15.
Zurück zum Zitat Kasiske BL, Snyder JJ, Matas AJ et al (2002) Preemptive kidney transplantation: the advantage and the advantaged. J Am Soc Nephrol 13:1358–1364PubMedCrossRef Kasiske BL, Snyder JJ, Matas AJ et al (2002) Preemptive kidney transplantation: the advantage and the advantaged. J Am Soc Nephrol 13:1358–1364PubMedCrossRef
17.
Zurück zum Zitat Koster I, Huppertz E, Hauner H et al (2014) Costs of diabetes mellitus (coDiM) in Germany, direct per-capita costs of managing hyperglycaemia and diabetes complications in 2010 compared to 2001. Exp Clin Endocrinol Diabetes 122:510–516PubMedCrossRef Koster I, Huppertz E, Hauner H et al (2014) Costs of diabetes mellitus (coDiM) in Germany, direct per-capita costs of managing hyperglycaemia and diabetes complications in 2010 compared to 2001. Exp Clin Endocrinol Diabetes 122:510–516PubMedCrossRef
18.
Zurück zum Zitat Koye DN, Magliano DJ, Reid CM et al (2019) Trends in incidence of ESKD in people with type 1 and type 2 diabetes in Australia, 2002–2013. Am J Kidney Dis 73:300–308PubMedCrossRef Koye DN, Magliano DJ, Reid CM et al (2019) Trends in incidence of ESKD in people with type 1 and type 2 diabetes in Australia, 2002–2013. Am J Kidney Dis 73:300–308PubMedCrossRef
19.
Zurück zum Zitat Kuriyama S (2007) Peritoneal dialysis in patients with diabetes: are the benefits greater than the disadvantages? Perit Dial Int 27(2):S190–195PubMed Kuriyama S (2007) Peritoneal dialysis in patients with diabetes: are the benefits greater than the disadvantages? Perit Dial Int 27(2):S190–195PubMed
20.
Zurück zum Zitat Lameire N, Van Biesen W (2010) Epidemiology of peritoneal dialysis: a story of believers and nonbelievers. Nat Rev Nephrol 6:75–82PubMedCrossRef Lameire N, Van Biesen W (2010) Epidemiology of peritoneal dialysis: a story of believers and nonbelievers. Nat Rev Nephrol 6:75–82PubMedCrossRef
21.
Zurück zum Zitat Li PK, Culleton BF, Ariza A et al (2013) Randomized, controlled trial of glucose-sparing peritoneal dialysis in diabetic patients. J Am Soc Nephrol 24:1889–1990PubMedPubMedCentralCrossRef Li PK, Culleton BF, Ariza A et al (2013) Randomized, controlled trial of glucose-sparing peritoneal dialysis in diabetic patients. J Am Soc Nephrol 24:1889–1990PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Lin X, Lin A, Ni Z et al (2010) Daily peritoneal ultrafiltration predicts patient and technique survival in anuric peritoneal dialysis patients. Nephrol Dial Transplant 25:2322–2327PubMedCrossRef Lin X, Lin A, Ni Z et al (2010) Daily peritoneal ultrafiltration predicts patient and technique survival in anuric peritoneal dialysis patients. Nephrol Dial Transplant 25:2322–2327PubMedCrossRef
23.
Zurück zum Zitat Luijtgaarden MW van de, Jager KJ, Segelmark M et al (2016) Trends in dialysis modality choice and related patient survival in the ERA-EDTA Registry over a 20-year period. Nephrol Dial Transplant 31:120–128PubMedCrossRef Luijtgaarden MW van de, Jager KJ, Segelmark M et al (2016) Trends in dialysis modality choice and related patient survival in the ERA-EDTA Registry over a 20-year period. Nephrol Dial Transplant 31:120–128PubMedCrossRef
24.
Zurück zum Zitat Machowska A, Alscher MD, Vanga SR et al (2017) Offering patients therapy options in unplanned start (OPtiONS): implementation of an educational program is feasible and effective. BMC Nephrol 18:18PubMedPubMedCentralCrossRef Machowska A, Alscher MD, Vanga SR et al (2017) Offering patients therapy options in unplanned start (OPtiONS): implementation of an educational program is feasible and effective. BMC Nephrol 18:18PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Martinez-Castelao A, Navarro-Gonzalez JF, Gorriz JL et al (2015) The concept and the epidemiology of diabetic nephropathy have changed in recent years. J Clin Med 4:1207–1216PubMedPubMedCentralCrossRef Martinez-Castelao A, Navarro-Gonzalez JF, Gorriz JL et al (2015) The concept and the epidemiology of diabetic nephropathy have changed in recent years. J Clin Med 4:1207–1216PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Mehrotra R, Chiu YW, Kalantar-Zadeh K et al (2009) The outcomes of continuous ambulatory and automated peritoneal dialysis are similar. Kidney Int 76:97–107PubMedCrossRef Mehrotra R, Chiu YW, Kalantar-Zadeh K et al (2009) The outcomes of continuous ambulatory and automated peritoneal dialysis are similar. Kidney Int 76:97–107PubMedCrossRef
27.
Zurück zum Zitat Mizumasa T, Hirakata H, Kuroki Y et al (2013) Diabetes influences peritoneal morphology in uremic patients at the initiation of peritoneal dialysis. Perit Dial Int 33:175–181PubMedPubMedCentralCrossRef Mizumasa T, Hirakata H, Kuroki Y et al (2013) Diabetes influences peritoneal morphology in uremic patients at the initiation of peritoneal dialysis. Perit Dial Int 33:175–181PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Nelson CB, Port FK, Wolfe RA et al (1992) Comparison of continuous ambulatory peritoneal dialysis and hemodialysis patient survival with evaluation of trends during the 1980s. J Am Soc Nephrol 3:1147–1155PubMed Nelson CB, Port FK, Wolfe RA et al (1992) Comparison of continuous ambulatory peritoneal dialysis and hemodialysis patient survival with evaluation of trends during the 1980s. J Am Soc Nephrol 3:1147–1155PubMed
29.
Zurück zum Zitat Noordzij M, Jager KJ (2014) Patient survival on dialysis in Korea: a different story? Kidney Int 86:877–880PubMedCrossRef Noordzij M, Jager KJ (2014) Patient survival on dialysis in Korea: a different story? Kidney Int 86:877–880PubMedCrossRef
30.
Zurück zum Zitat Quellhorst E (2002) Insulin therapy during peritoneal dialysis: pros and cons of various forms of administration. J Am Soc Nephrol 13(1):S92–96PubMed Quellhorst E (2002) Insulin therapy during peritoneal dialysis: pros and cons of various forms of administration. J Am Soc Nephrol 13(1):S92–96PubMed
31.
Zurück zum Zitat Quinn RR, Hux JE, Oliver MJ et al (2011) Selection bias explains apparent differential mortality between dialysis modalities. J Am Soc Nephrol 22:1534–1542PubMedPubMedCentralCrossRef Quinn RR, Hux JE, Oliver MJ et al (2011) Selection bias explains apparent differential mortality between dialysis modalities. J Am Soc Nephrol 22:1534–1542PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Saran R, Robinson B, Abbott KC et al (2020) US renal data system 2019 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis 75:A6–A7PubMedCrossRef Saran R, Robinson B, Abbott KC et al (2020) US renal data system 2019 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis 75:A6–A7PubMedCrossRef
33.
Zurück zum Zitat Tamayo T, Brinks R, Hoyer A et al (2016) The prevalence and incidence of diabetes in Germany. Dtsch Arztebl Int 113:177–182PubMedPubMedCentral Tamayo T, Brinks R, Hoyer A et al (2016) The prevalence and incidence of diabetes in Germany. Dtsch Arztebl Int 113:177–182PubMedPubMedCentral
34.
Zurück zum Zitat Thomas B, Wulf S, Bikbov B et al (2015) Maintenance dialysis throughout the world in years 1990 and 2010. J Am Soc Nephrol 26:2621–2633PubMedPubMedCentralCrossRef Thomas B, Wulf S, Bikbov B et al (2015) Maintenance dialysis throughout the world in years 1990 and 2010. J Am Soc Nephrol 26:2621–2633PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat U.S. Renal Data System UaDR (2012) Atlas of chronic kidney disease and end-stage renal disease in the United States, 2012. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD U.S. Renal Data System UaDR (2012) Atlas of chronic kidney disease and end-stage renal disease in the United States, 2012. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
36.
Zurück zum Zitat Vonesh EF, Snyder JJ, Foley RN et al (2004) The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis. Kidney Int 66:2389–2401PubMedCrossRef Vonesh EF, Snyder JJ, Foley RN et al (2004) The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis. Kidney Int 66:2389–2401PubMedCrossRef
37.
Zurück zum Zitat Wang IK, Lin CL, Yen TH et al (2018) Comparison of survival between hemodialysis and peritoneal dialysis patients with end-stage renal disease in the era of icodextrin treatment. Eur J Intern Med 50:69–74PubMedCrossRef Wang IK, Lin CL, Yen TH et al (2018) Comparison of survival between hemodialysis and peritoneal dialysis patients with end-stage renal disease in the era of icodextrin treatment. Eur J Intern Med 50:69–74PubMedCrossRef
38.
Zurück zum Zitat Watnick S, Silberzweig J (2019) Transforming care for patients and providers: perspective from nonprofit providers. Clin J Am Soc Nephrol 14:1805–1807PubMedCrossRef Watnick S, Silberzweig J (2019) Transforming care for patients and providers: perspective from nonprofit providers. Clin J Am Soc Nephrol 14:1805–1807PubMedCrossRef
39.
Zurück zum Zitat Williams JD, Craig KJ, Ruhland C von et al (2003) The natural course of peritoneal membrane biology during peritoneal dialysis. Kidney Int Suppl 88:S43–49CrossRef Williams JD, Craig KJ, Ruhland C von et al (2003) The natural course of peritoneal membrane biology during peritoneal dialysis. Kidney Int Suppl 88:S43–49CrossRef
40.
Zurück zum Zitat Xue J, Li H, Zhou Q et al (2019) Comparison of peritoneal dialysis with hemodialysis on survival of diabetic patients with end-stage kidney disease: a meta-analysis of cohort studies. Ren Fail 41:521–531PubMedPubMedCentralCrossRef Xue J, Li H, Zhou Q et al (2019) Comparison of peritoneal dialysis with hemodialysis on survival of diabetic patients with end-stage kidney disease: a meta-analysis of cohort studies. Ren Fail 41:521–531PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Yarragudi R, Gessl A, Vychytil A (2019) New-onset diabetes mellitus in peritoneal dialysis and hemodialysis patients: frequency, risk factors, and prognosis—a review. Ther Apher Dial 23:497–506PubMedPubMedCentralCrossRef Yarragudi R, Gessl A, Vychytil A (2019) New-onset diabetes mellitus in peritoneal dialysis and hemodialysis patients: frequency, risk factors, and prognosis—a review. Ther Apher Dial 23:497–506PubMedPubMedCentralCrossRef
Metadaten
Titel
Welche Dialysebehandlung bei diabetischer Nephropathie?
verfasst von
Prof. Dr. M. D. Alscher
Publikationsdatum
08.04.2020
Verlag
Springer Medizin
Erschienen in
Die Nephrologie / Ausgabe 3/2020
Print ISSN: 2731-7463
Elektronische ISSN: 2731-7471
DOI
https://doi.org/10.1007/s11560-020-00425-7

Weitere Artikel der Ausgabe 3/2020

Die Nephrologie 3/2020 Zur Ausgabe

Einführung zum Thema

Diabetische Nephropathie

Mitteilungen des BDI

Mitteilungen des BDI

Praxisempfehlungen der Deutschen Diabetes Gesellschaft

Kurz, prägnant und aktuell: Die Praxisempfehlungen der Deutschen Diabetes Gesellschaft.