Diabetologia

Up Front

Global trends in diabetes complications: a review of current evidence

Jessica L. Harding, Meda E. Pavkov, Dianna J. Magliano, Jonathan E. Shaw, Edward W. Gregg

Dynamics of adipose tissue turnover in human metabolic health and disease

Ursula White, Eric Ravussin

Screening for type 1 diabetes: are we nearly there yet?

Parth Narendran

Capturing residual beta cell function in type 1 diabetes

Flemming Pociot

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

John M. Wentworth, Naiara G. Bediaga, Lynne C. Giles, Mario Ehlers, Stephen E. Gitelman, Susan Geyer, Carmella Evans-Molina, Leonard C. Harrison

Clinical outcomes of an integrated primary–secondary model of care for individuals with complex type 2 diabetes: a non-inferiority randomised controlled trial

Anthony W. Russell, Maria Donald, Samantha J. Borg, Jianzhen Zhang, Letitia H. Burridge, Robert S. Ware, Nelufa Begum, H. David McIntyre, Claire L. Jackson

Effect of screening for type 1 diabetes on early metabolic control: the DiPiS study

Markus Lundgren, Berglind Jonsdottir, Helena Elding Larsson

Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions

Ronald B. Goldberg, George A. Bray, Santica M. Marcovina, Kieren J. Mather, Trevor J. Orchard, Leigh Perreault, Marinella Temprosa

Trajectories of childhood BMI and adult diabetes: the Bogalusa Heart Study

Tao Zhang, Jie Xu, Shengxu Li, Lydia A. Bazzano, Jiang He, Paul K. Whelton, Wei Chen

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer–Cardiovascular Cohort

Xue Bao, Yan Borné, Iram Faqir Muhammad, Jan Nilsson, Lars Lind, Olle Melander, Kaijun Niu, Marju Orho-Melander, Gunnar Engström

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

Kaiyven A. Leslie, Mark A. Russell, Kazuto Taniguchi, Sarah J. Richardson, Noel G. Morgan

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

James Cantley, Aimee Davenport, Laurène Vetterli, Nandor J. Nemes, P. Tess Whitworth, Ebru Boslem, Le May Thai, Natalie Mellett, Peter J. Meikle, Kyle L. Hoehn, David E. James, Trevor J. Biden

Effect of l-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study

Mariëtte R. Boon, Mark J. W. Hanssen, Boudewijn Brans, Cindy J. M. Hülsman, Joris Hoeks, Kimberly J. Nahon, Charlotte Bakker, Jan B. van Klinken, Bas Havekes, Gert Schaart, Ingrid M. Jazet, Patrick C. N. Rensen, Wouter D. van Marken Lichtenbelt

Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice

Julio Sevillano, María Gracia Sánchez-Alonso, Begoña Zapatería, María Calderón, Martín Alcalá, María Limones, Jimena Pita, Esther Gramage, Marta Vicente-Rodríguez, Daniel Horrillo, Gema Medina-Gómez, María Jesús Obregón, Marta Viana, Ismael Valladolid-Acebes, Gonzalo Herradón, María Pilar Ramos-Álvarez

The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice

Erin S. Coyne, Nathalie Bédard, Ying Jia Gong, May Faraj, André Tchernof, Simon S. Wing

A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study

Joachim Gæde, Jens Oellgaard, Rikke Ibsen, Peter Gæde, Emil Nørtoft, Hans-Henrik Parving, Jakob Kjellberg, Oluf Pedersen

Serum kidney injury molecule 1 and β2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes

Marco Colombo, Helen C. Looker, Bassam Farran, Sibylle Hess, Leif Groop, Colin N. A. Palmer, Mary Julia Brosnan, R. Neil Dalton, Max Wong, Charles Turner, Emma Ahlqvist, David Dunger, Felix Agakov, Paul Durrington, Shona Livingstone, John Betteridge, Paul M. McKeigue, Helen M. Colhoun

Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes

Chi Ho Lee, Chloe Y. Y. Cheung, Yu Cho Woo, David T. W. Lui, Michele M. A. Yuen, Carol H. Y. Fong, Wing Sun Chow, Amin Xu, Karen S. L. Lam

Postprandial hypoglycaemia after Roux-en-Y gastric bypass in individuals with type 2 diabetes

Daniela Guarino, Diego Moriconi, Andrea Mari, Eleni Rebelos, Daria Colligiani, Simona Baldi, Marco Anselmino, Ele Ferrannini, Monica Nannipieri

Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes

Paul G. Weightman Potter, Julia M. Vlachaki Walker, Josephine L. Robb, John K. Chilton, Ritchie Williamson, Andrew D Randall, Kate L. J. Ellacott, Craig Beall

Is there evidence for sex differences in the association between diabetes and cancer?

Rachel Dankner, Lital Keinan Boker, Laurence S. Freedman

Is there evidence for sex differences in the association between diabetes and cancer? Reply to Dankner R, Boker LK, Freedman LS [letter]

Toshiaki Ohkuma, Sanne A. E. Peters, Mark Woodward

Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’

Payam Amini, Sevda Moharamzadeh

Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’. Reply to Amini P and Moharamzadeh S [letter]

Marja A. Heiskanen, Kumail K. Motiani, Andrea Mari, Jari-Joonas Eskelinen, Kirsi A. Virtanen, Eliisa Löyttyniemi, Kari K. Kalliokoski, Jarna C. Hannukainen