Ausgabe 10/2020
Inhalt (31 Artikel)
Up front
Organisation of the human pancreas in health and in diabetes
Mark A. Atkinson, Martha Campbell-Thompson, Irina Kusmartseva, Klaus H. Kaestner
Transcription factors that shape the mammalian pancreas
Rachel E. Jennings, Raphael Scharfmann, Willem Staels
The making of insulin in health and disease
Jovana Vasiljević, Juha M. Torkko, Klaus-Peter Knoch, Michele Solimena
Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity
Guy A. Rutter, Eleni Georgiadou, Aida Martinez-Sanchez, Timothy J. Pullen
Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
Roberto Mallone, Decio L. Eizirik
Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
Nathalie Esser, Kristina M. Utzschneider, Steven E. Kahn
A tale of two pancreases: exocrine pathology and endocrine dysfunction
Michael R. Rickels, Andrew W. Norris, Rebecca L. Hull
The clinical consequences of heterogeneity within and between different diabetes types
Maria J. Redondo, William A. Hagopian, Richard Oram, Andrea K. Steck, Kendra Vehik, Michael Weedon, Ashok Balasubramanyam, Dana Dabelea
Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies
Melena D. Bellin, Ty B. Dunn
Alpha cell regulation of beta cell function
Tilo Moede, Ingo B. Leibiger, Per-Olof Berggren
Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect
Joana Almaça, Alejandro Caicedo, Limor Landsman
CNS control of the endocrine pancreas
Chelsea L. Faber, Jennifer D. Deem, Carlos A. Campos, Gerald J. Taborsky Jr., Gregory J. Morton
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes
Rafael Arrojo e Drigo, Birbickram Roy, Patrick E. MacDonald
Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study
Sufei Wang, Pei Ma, Shujing Zhang, Siwei Song, Zhihui Wang, Yanling Ma, Juanjuan Xu, Feng Wu, Limin Duan, Zhengrong Yin, Huilin Luo, Nian Xiong, Man Xu, Tianshu Zeng, Yang Jin
Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme
Yiqiao Xin, Andrew Davies, Andrew Briggs, Louise McCombie, C. Martina Messow, Eleanor Grieve, Wilma S. Leslie, Roy Taylor, Michael E. J. Lean
Type 1 and type 2 diabetes after gestational diabetes: a 23 year cohort study
Anna-Maaria Auvinen, Kaisu Luiro, Jari Jokelainen, Ilkka Järvelä, Mikael Knip, Juha Auvinen, Juha S. Tapanainen
Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study
Francesco Zaccardi, Suping Ling, Claire Lawson, Melanie J. Davies, Kamlesh Khunti
The metabolic syndrome in pregnancy and its association with child telomere length
Dale McAninch, Tina Bianco-Miotto, Kathy L. Gatford, Shalem Y. Leemaqz, Prabha H. Andraweera, Amy Garrett, Michelle D. Plummer, Gus A. Dekker, Claire T. Roberts, Lisa G. Smithers, Jessica A. Grieger
Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology
Linlin Cui, Wei Zhou, Bo Xi, Jinlong Ma, Jingmei Hu, Mei Fang, Kuona Hu, Yingying Qin, Li You, Yongzhi Cao, Lili Yang, Liu Yang, Chuanwei Ma, Wang Shui, Mingming Wang, Min Zhao, Jun Zhang, Zi-Jiang Chen
Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia
Shitaye A. Balcha, Abayneh G. Demisse, Rajashree Mishra, Tanwi Vartak, Diana L. Cousminer, Kenyaita M. Hodge, Benjamin F. Voight, Kim Lorenz, Stanley Schwartz, Samuel T. Jerram, Arla Gamper, Alice Holmes, Hannah F. Wilson, Alistair J. K. Williams, Struan F. A. Grant, R. David Leslie, David I. W. Phillips, Elisabeth R. Trimble
The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity
Mohanraj Krishnan, Rinki Murphy, Karaponi A. M. Okesene-Gafa, Maria Ji, John M. D. Thompson, Rennae S. Taylor, Tony R. Merriman, Lesley M. E. McCowan, Christopher J. D. McKinlay
Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes
Ulf Hannelius, Craig A. Beam, Johnny Ludvigsson
Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes
Christin Krause, Cathleen Geißler, Heidi Tackenberg, Alexander T. El Gammal, Stefan Wolter, Joachim Spranger, Oliver Mann, Hendrik Lehnert, Henriette Kirchner
Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes
Celeste K. L. Cravalho, Abby G. Meyers, Lilian S. Mabundo, Amber Courville, Shanna Yang, Hongyi Cai, Yuhai Dai, Mary Walter, Peter J. Walter, Susan Sharma, Shaji Chacko, Fran Cogen, Sheela N. Magge, Morey W. Haymond, Stephanie T. Chung
Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus
Ashton Faulkner, Anita Tamiato, William Cathery, Andrea Rampin, Carlo Maria Caravaggi, Eva Jover, Steve Allen, Harry Mellor, David Hauton, Lisa C. Heather, Gaia Spinetti, Paolo Madeddu
Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo
Christian Stern, Barbara Schreier, Alexander Nolze, Sindy Rabe, Sigrid Mildenberger, Michael Gekle
Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy
Inge Van Hove, Lies De Groef, Bram Boeckx, Elodie Modave, Tjing-Tjing Hu, Karen Beets, Isabelle Etienne, Tine Van Bergen, Diether Lambrechts, Lieve Moons, Jean H. M. Feyen, Michaël Porcu