Diabetologia

Up front

PCSK9 inhibition: the dawn of a new age in cholesterol lowering?

David Preiss, Marion Mafham

Adding exercise or subtracting sitting time for glycaemic control: where do we stand?

Paddy C. Dempsey, Megan S. Grace, David W. Dunstan

The cardiovascular benefits of empagliflozin: SGLT2-dependent and -independent effects

Roberto Vettor, Silvio E. Inzucchi, Paola Fioretto

Increased fetal adiposity prior to diagnosis of gestational diabetes in South Asians: more evidence for the ‘thin–fat’ baby

Hema Venkataraman, Uma Ram, Sam Craik, Anuradhai Arungunasekaran, Suresh Seshadri, Ponnusamy Saravanan

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

Megan L. Gow, Louise A. Baur, Nathan A. Johnson, Chris T. Cowell, Sarah P. Garnett

Are the Institute of Medicine weight gain targets applicable in women with gestational diabetes mellitus?

Tang Wong, Robyn A. Barnes, Glynis P. Ross, Ngai W. Cheung, Jeff R. Flack

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity

Hanna Honkanen, Sami Oikarinen, Noora Nurminen, Olli H. Laitinen, Heini Huhtala, Jussi Lehtonen, Tanja Ruokoranta, Minna M. Hankaniemi, Valérie Lecouturier, Jeffrey W. Almond, Sisko Tauriainen, Olli Simell, Jorma Ilonen, Riitta Veijola, Hanna Viskari, Mikael Knip, Heikki Hyöty

Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study

Louise J. C. J. den Biggelaar, Simone J. S. Sep, Simone J. P. M. Eussen, Andrea Mari, Ele Ferrannini, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Casper G. Schalkwijk, Coen D. A. Stehouwer, Pieter C. Dagnelie

The heritable basis of gene–environment interactions in cardiometabolic traits

Alaitz Poveda, Yan Chen, Anders Brändström, Elisabeth Engberg, Göran Hallmans, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks

Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide

Jaques A. Courtade, Evan Y. Wang, Paul Yen, Derek L. Dai, Galina Soukhatcheva, Paul C. Orban, C. Bruce Verchere

APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes

Xue Jiang, Yawen Zhou, Kelvin K. L. Wu, Zhanrui Chen, Aimin Xu, Kenneth K. Y. Cheng

Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis

Inne Crèvecoeur, Valborg Gudmundsdottir, Saurabh Vig, Fernanda Marques Câmara Sodré, Wannes D’Hertog, Ana Carolina Fierro, Leentje Van Lommel, Conny Gysemans, Kathleen Marchal, Etienne Waelkens, Frans Schuit, Søren Brunak, Lut Overbergh, Chantal Mathieu

Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes

Bernard M. F. M. Duvivier, Nicolaas C. Schaper, Matthijs K. C. Hesselink, Linh van Kan, Nathalie Stienen, Bjorn Winkens, Annemarie Koster, Hans H. C. M. Savelberg

Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control

Paddy C. Dempsey, Jennifer M. Blankenship, Robyn N. Larsen, Julian W. Sacre, Parneet Sethi, Nora E. Straznicky, Neale D. Cohen, Ester Cerin, Gavin W. Lambert, Neville Owen, Bronwyn A. Kingwell, David W. Dunstan

The effects of 2 weeks of interval vs continuous walking training on glycaemic control and whole-body oxidative stress in individuals with type 2 diabetes: a controlled, randomised, crossover trial

Kristian Karstoft, Margaret A. Clark, Ida Jakobsen, Ida A. Müller, Bente K. Pedersen, Thomas P. J. Solomon, Mathias Ried-Larsen

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Victoria Sandler, Anna C. Reisetter, James R. Bain, Michael J. Muehlbauer, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise M. Scholtens, William L. Lowe Jr

Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia

Colleen M. Craig, Li-Fen Liu, Carolyn F. Deacon, Jens J. Holst, Tracey L. McLaughlin

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice

Annie Hasib, Ming T. Ng, Victor A. Gault, Dawood Khan, Vadivel Parthsarathy, Peter R. Flatt, Nigel Irwin

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

Urszula Chursa, Esther Nuñez-Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria E. Johansson, Fredrik Bäckhed, Bengt R. Johansson, Carina Sihlbom, Margit Mahlapuu

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

Antonius Baartscheer, Cees A. Schumacher, Rob C. I. Wüst, Jan W. T. Fiolet, Ger J. M. Stienen, Ruben Coronel, Coert J. Zuurbier

Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes

Heidi Tikkanen-Dolenc, Johan Wadén, Carol Forsblom, Valma Harjutsalo, Lena M. Thorn, Markku Saraheimo, Nina Elonen, Milla Rosengård-Bärlund, Daniel Gordin, Heikki O. Tikkanen, Per-Henrik Groop

Assessment of urinary microparticles in normotensive patients with type 1 diabetes

Yuliya Lytvyn, Fengxia Xiao, Christopher R. J. Kennedy, Bruce A. Perkins, Heather N. Reich, James W. Scholey, David Z. Cherney, Dylan Burger

SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes

Weier Qi, Qian Li, Chong Wee Liew, Christian Rask-Madsen, Samuel M. Lockhart, Lars Melholt Rasmussen, Yu Xia, Xuanchun Wang, Mogher Khamaisi, Kevin Croce, George L. King

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes

Takeru Shima, Takashi Matsui, Subrina Jesmin, Masahiro Okamoto, Mariko Soya, Koshiro Inoue, Yu-Fan Liu, Ignacio Torres-Aleman, Bruce S. McEwen, Hideaki Soya