Diabetologia

Up front

The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities

Louise Brunkwall, Marju Orho-Melander

The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes

Meghan F. Hogan, Rebecca L. Hull

Human genetics as a model for target validation: finding new therapies for diabetes

Soren K. Thomsen, Anna L. Gloyn

Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes

Tor I. Hansen, Sandra E. Olsen, Elise C. D. Haferstrom, Trond Sand, Brian M. Frier, Asta K. Håberg, Marit R. Bjørgaas

Effects of a long-term lifestyle modification programme on peripheral neuropathy in overweight or obese adults with type 2 diabetes: the Look AHEAD study

Effect of diet-induced weight loss on lipoprotein(a) levels in obese individuals with and without type 2 diabetes

Kirsten A. Berk, Reyhana Yahya, Adrie J. M. Verhoeven, Jeanette Touw, Frank P. Leijten, Elisabeth F. van Rossum, Vincent L. Wester, Mirjam A. Lips, Hanno Pijl, Reinier Timman, Gertraud Erhart, Florian Kronenberg, Jeanine E. Roeters van Lennep, Eric J. G. Sijbrands, Monique T. Mulder

Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY)

Brigitte I. Frohnert, Lisa Ide, Fran Dong, Anna E. Barón, Andrea K. Steck, Jill M. Norris, Marian J. Rewers

Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation

Francesco Zaccardi, David R. Webb, Melanie J. Davies, Nafeesa N. Dhalwani, Laura J. Gray, Sudesna Chatterjee, Gemma Housley, Dominick Shaw, James W. Hatton, Kamlesh Khunti

Does training of general practitioners for intensive treatment of people with screen-detected diabetes have a spillover effect on mortality and cardiovascular morbidity in ‘at risk’ individuals with normoglycaemia? Results from the ADDITION-Denmark cluster-randomised controlled trial

Rebecca K. Simmons, Niels H. Bruun, Daniel R. Witte, Knut Borch-Johnsen, Marit E. Jørgensen, Annelli Sandbæk, Torsten Lauritzen

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N. Luu, Prakash C. Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Yong-Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K. Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You-Lin Qiao, San-Lin You, Renwei Wang, Myung-Hee Shin, Wen-Harn Pan, Mangesh S. Pednekar, Shoichiro Tsugane, Hui Cai, Jian-Min Yuan, Yu-Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D. Potter

Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes

Allen L. Feng, Yun-Yan Xiang, Le Gui, Gesthika Kaltsidis, Qingping Feng, Wei-Yang Lu

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice

Gabriela da Silva Xavier, Angeles Mondragon, Vishnou Mourougavelou, Céline Cruciani-Guglielmacci, Jessica Denom, Pedro Luis Herrera, Christophe Magnan, Guy A. Rutter

Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice

Willem Staels, Yves Heremans, Gunter Leuckx, Naomi Van Gassen, Ciro Salinno, Sofie De Groef, Martine Cools, Eli Keshet, Yuval Dor, Harry Heimberg, Nico De Leu

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells

Emily K. Sims, Alexander J. Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Xin Tong, Carmella Evans-Molina

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans

Mahesha H. Gangadhariah, Blake W. Dieckmann, Louise Lantier, Li Kang, David H. Wasserman, Manuel Chiusa, Charles F. Caskey, Jaime Dickerson, Pengcheng Luo, Jorge L. Gamboa, Jorge H. Capdevila, John D. Imig, Chang Yu, Ambra Pozzi, James M. Luther

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice

Iliana López-Soldado, Rebeca Fuentes-Romero, Jordi Duran, Joan J. Guinovart

Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice

Na Xiao, Meng-Die Lou, Yi-Tong Lu, Le-Le Yang, Qun Liu, Baolin Liu, Lian-Wen Qi, Ping Li

Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study

Shazli Azmi, Maryam Ferdousi, Uazman Alam, Ioannis N. Petropoulos, Georgios Ponirakis, Andrew Marshall, Omar Asghar, Hassan Fadavi, Wendy Jones, Mitra Tavakoli, Andrew J. M. Boulton, Maria Jeziorska, Handrean Soran, Nathan Efron, Rayaz A. Malik

Evidence for two distinct phenotypes of chronic kidney disease in individuals with type 1 diabetes mellitus

Giuseppe Penno, Eleonora Russo, Monia Garofolo, Giuseppe Daniele, Daniela Lucchesi, Laura Giusti, Veronica Sancho Bornez, Cristina Bianchi, Angela Dardano, Roberto Miccoli, Stefano Del Prato

MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy

Cristina Zanchi, Daniela Macconi, Piera Trionfini, Susanna Tomasoni, Daniela Rottoli, Monica Locatelli, Michael Rudnicki, Jo Vandesompele, Pieter Mestdagh, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja

CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats

Zhen-Guo Ma, Yu-Pei Yuan, Si-Chi Xu, Wen-Ying Wei, Chun-Ru Xu, Xin Zhang, Qing-Qing Wu, Hai-Han Liao, Jian Ni, Qi-Zhu Tang

Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice

Mika Kina-Tanada, Mayuko Sakanashi, Akihide Tanimoto, Tadashi Kaname, Toshihiro Matsuzaki, Katsuhiko Noguchi, Taro Uchida, Junko Nakasone, Chisayo Kozuka, Masayoshi Ishida, Haruaki Kubota, Yuji Taira, Yuichi Totsuka, Shin-ichiro Kina, Hajime Sunakawa, Junichi Omura, Kimio Satoh, Hiroaki Shimokawa, Nobuyuki Yanagihara, Shiro Maeda, Yusuke Ohya, Masayuki Matsushita, Hiroaki Masuzaki, Akira Arasaki, Masato Tsutsui

INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters

Elisabeth Kemter, Christian M. Cohrs, Matthias Schäfer, Marion Schuster, Klaus Steinmeyer, Lelia Wolf-van Buerck, Andrea Wolf, Annegret Wuensch, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Matthias Loehn, Yuri Ivashchenko, Jochen Seissler, Anke M. Schulte, Stephan Speier, Eckhard Wolf

The Berlin Declaration: building upon St Vincent

Anne-Marie Felton, Sanjay Kalra

Erratum to: Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration

Marko Škrtić, Gary K. Yang, Bruce A. Perkins, Nima Soleymanlou, Yuliya Lytvyn, Maximilian von Eynatten, Hans J. Woerle, Odd Erik Johansen, Uli C. Broedl, Thomas Hach, Melvin Silverman, David Z. I. Cherney