Ausgabe 8/2014
Inhalt (25 Artikel)
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
Rinke Stienstra, Yulia Haim, Yael Riahi, Mihai Netea, Assaf Rudich, Gil Leibowitz
Impaired proteostasis: role in the pathogenesis of diabetes mellitus
Stéphane Jaisson, Philippe Gillery
Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
Niels Grarup, Camilla H. Sandholt, Torben Hansen, Oluf Pedersen
Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events
Sanne A. E. Peters, Rachel R. Huxley, Mark Woodward
Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover study
Hana Kahleova, Lenka Belinova, Hana Malinska, Olena Oliyarnyk, Jaroslava Trnovska, Vojtech Skop, Ludmila Kazdova, Monika Dezortova, Milan Hajek, Andrea Tura, Martin Hill, Terezie Pelikanova
Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
Hong Xu, Ting Jia, Xiaoyan Huang, Ulf Risérus, Tommy Cederholm, Johan Ärnlöv, Per Sjögren, Bengt Lindholm, Juan-Jesús Carrero
Aberrant gut microbiota composition at the onset of type 1 diabetes in young children
Marcus C. de Goffau, Susana Fuentes, Bartholomeus van den Bogert, Hanna Honkanen, Willem M. de Vos, Gjalt W. Welling, Heikki Hyöty, Hermie J. M. Harmsen
Contrasting the clinical care and outcomes of 2,622 children with type 1 diabetes less than 6 years of age in the United States T1D Exchange and German/Austrian DPV registries
David M. Maahs, Julia M. Hermann, Stephanie N. DuBose, Kellee M. Miller, Bettina Heidtmann, Linda A. DiMeglio, Birgit Rami-Merhar, Roy W. Beck, Edith Schober, William V. Tamborlane, Thomas M. Kapellen, Reinhard W. Holl
Changes in HbA1c and frequency of measuring HbA1c and adjusting glucose-lowering medications in the 10 years following diagnosis of type 2 diabetes: a population-based study in the UK
Marcus Lind, Aldina Pivodic, Lucia Cea-Soriano, Olle Nerman, Nils-Gunnar Pehrsson, Luis A. Garcia-Rodriguez
Association of heart failure severity with risk of diabetes: a Danish nationwide cohort study
Malene N. Demant, Gunnar H. Gislason, Lars Køber, Allan Vaag, Christian Torp-Pedersen, Charlotte Andersson
Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study
Martine Vaxillaire, Loïc Yengo, Stéphane Lobbens, Ghislain Rocheleau, Elodie Eury, Olivier Lantieri, Michel Marre, Beverley Balkau, Amélie Bonnefond, Philippe Froguel
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
Francesco Sambo, Alberto Malovini, Niina Sandholm, Monica Stavarachi, Carol Forsblom, Ville-Petteri Mäkinen, Valma Harjutsalo, Raija Lithovius, Daniel Gordin, Maija Parkkonen, Markku Saraheimo, Lena M. Thorn, Nina Tolonen, Johan Wadén, Bing He, Anne-May Österholm, Jaako Tuomilehto, Maria Lajer, Rany M. Salem, Amy Jayne McKnight, Lise Tarnow, Nicolae M. Panduru, Nicola Barbarini, Barbara Di Camillo, Gianna M. Toffolo, Karl Tryggvason, Riccardo Bellazzi, Claudio Cobelli, Per-Henrik Groop
GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence
Karen M. Eny, Helen L. Lutgers, John Maynard, Barbara E. K. Klein, Kristine E. Lee, Gil Atzmon, Vincent M. Monnier, Jana V. van Vliet-Ostaptchouk, Reindert Graaff, Pim van der Harst, Harold Snieder, Melanie M. van der Klauw, David R. Sell, S. Mohsen Hosseini, Patricia A. Cleary, Barbara H. Braffett, Trevor J. Orchard, Timothy J. Lyons, Kerri Howard, Ronald Klein, Jill P. Crandall, Nir Barzilai, Sofiya Milman, Danny Ben-Avraham, Bruce H. R. Wolffenbuttel, Andrew D. Paterson
Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
Philipp A. Gerber, Elisa A. Bellomo, David J. Hodson, Gargi Meur, Antonia Solomou, Ryan K. Mitchell, Michael Hollinshead, Fabrice Chimienti, Domenico Bosco, Stephen J. Hughes, Paul R. V. Johnson, Guy A. Rutter
TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6
Dominika Nackiewicz, Meixia Dan, Wei He, Rosa Kim, Anisa Salmi, Sabine Rütti, Clara Westwell-Roper, Amanda Cunningham, Madeleine Speck, Carole Schuster-Klein, Beatrice Guardiola, Kathrin Maedler, Jan A. Ehses
Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature
Jiun T. Low, Michael Zavortink, Justin M. Mitchell, Wan J. Gan, Oanh Hoang Do, Christof J. Schwiening, Herbert Y. Gaisano, Peter Thorn
Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes
Enrica Favaro, Andrea Carpanetto, Sara Lamorte, Alberto Fusco, Cristiana Caorsi, Maria C. Deregibus, Stefania Bruno, Antonio Amoroso, Mirella Giovarelli, Massimo Porta, Paolo Cavallo Perin, Ciro Tetta, Giovanni Camussi, Maria M. Zanone
Cathepsin S inhibition lowers blood glucose levels in mice
Jean-Charles Lafarge, Maria Pini, Véronique Pelloux, Gabriela Orasanu, Guido Hartmann, Nicolas Venteclef, Thierry Sulpice, Guo-Ping Shi, Karine Clément, Michèle Guerre-Millo
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
D. Lee Hamilton, John A. Findlay, Gemma Montagut, Paul J. Meakin, Dawn Bestow, Susan M. Jalicy, Michael L. J. Ashford
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
Hayley M. O’Neill, James S. Lally, Sandra Galic, Melissa Thomas, Paymon D. Azizi, Morgan D. Fullerton, Brennan K. Smith, Thomas Pulinilkunnil, Zhiping Chen, M. Constantine Samaan, Sebastian B. Jorgensen, Jason R. B. Dyck, Graham P. Holloway, Thomas J. Hawke, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg
Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study
Björn Rathsman, Kerstin Jensen-Urstad, Thomas Nyström
Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome
Moaz A. Mojaddidi, Mohammed S. Ahmed, Razwan Ali, Maria Jeziorska, Ahmed Al-Sunni, Niels O. B. Thomsen, Lars B. Dahlin, Rayaz A. Malik
Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals
Jonatan I. Bagger, Filip K. Knop, Asger Lund, Jens J. Holst, Tina Vilsbøll
MiR-135a promotes renal fibrosis in diabetic nephropathy by regulating TRPC1
Feng He, Fenfen Peng, Xi Xia, Chen Zhao, Qimei Luo, Weiming Guan, Zhijian Li, Xueqing Yu, Fengxian Huang
Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3
Katharina Hess, Saad H. Alzahrani, Jackie F. Price, Mark W. Strachan, Natalie Oxley, Rhodri King, Tobias Gamlen, Verena Schroeder, Paul D. Baxter, Ramzi A. Ajjan