Background
The diagnosis of labor onset has been described as one of the most difficult and important judgments made by providers of maternity care [
1]. The first stage of labor, through effective uterine contractions, achieves the objective of shortening or effacing the cervix, and opening or dilating it to at least 10 cm in diameter to allow the passage of the infant from the uterus to the vagina. It is comprised of two phases; latent and active.
There is compelling evidence that the duration of both latent and active phases of labor are clinically relevant and thus require consistent approaches to measurement. A prolonged latent phase of labor has been associated with an increased risk for oxytocin augmentation of labor, caesarean section, meconium staining in the amniotic fluid, 5-min Apgar score less than 7, need for newborn resuscitation and admission to the NICU [
2,
3]. Women who are admitted to labor wards in the latent vs. active phase of labor are at higher risk for obstetrical intervention including electronic fetal monitoring, epidural analgesia, oxytocin, and caesarean section [
4‐
7]. There may also be important differences in durations of latent and active phase labor and their relationship to obstetric outcomes according to parity.
Despite research pointing to the importance of the duration and transition between the latent and active phases of labor, there is considerable inconsistency in definitions of labor onset, a necessary component of measuring duration. The onset of the latent phase of labor has been defined as the time of the first clinical assessment in labor at the hospital [
3,
5], or alternatively the beginning of strong regular painful contractions [
2]. Similarly, inconsistency exists in definitions of the transition from the latent to the active phase. This important indicator of labor progress has been variably characterized as coinciding with the onset of regular contractions [
8], beginning at the time at which the woman was admitted to the labor ward [
9], when she seeks professional care [
10], or the time at which she is consented for participation in a randomized controlled trial [
11]. Recently researchers have used the woman’s self-report as the time of labor onset [
8,
12‐
14].
Friedman originally defined the onset of the active phase of labor as the point in time when the rate of change of cervical dilatation significantly increases [
15]. In practice many clinicians view 3 or 4 cm cervical dilation as the beginning of active phase labor [
16], including the WHO’s partograph which is based on the principle that active phase of labor commences at 3 cm cervical dilatation and that during active labor the rate of cervical dilatation should not be slower than 1 cm/h [
17]. Zhang et al.’s study of 1329 women in spontaneous labor at term with a singleton fetus in vertex presentation found contrasting findings. They reported that the cervix dilated substantially more slowly in the active phase than had been reported by Friedman, taking approximately 5.5 h to dilate from 4 cm to 10 cm, compared with Friedman’s reported 2.5 h and concluded that most women entered the active phase between 3 cm and 5 cm of cervical dilation [
18]. A more recent retrospective study that analyzed labor trajectories of 62,415 women who vaginally delivered a singleton fetus with vertex presentation reported that the 95th percentile rate of active phase dilation was substantially slower than the standard rate derived from Friedman’s work, varying from 0.5 cm/h to 0.7 cm/h for nulliparous women and from 0.5 cm/h to 1.3 cm/h for multiparous women [
19].
Influenced by this work, the American College of Obstetricians and Gynecologists recently released an obstetric care consensus statement explicitly stating that contemporary labor progresses at a rate substantially slower than historically believed. They state that because the maximal slope in the rate of change of cervical dilatation (i.e., the active phase of labor) did not start until at least 6 cm, a cervical dilatation of 6 cm should be considered the threshold for the active phase of most women in labor [
20].
The controversy around definitions of labor onset probably stems, at least in part, from the lack of clear understanding of the biology of parturition. Changes in levels of fetal adrenal, pituitary, and placental hormones, paracrine signalling molecules and inflammatory mediators, occur on a continuum over a period of days to weeks and initiate factors that act to promote uterine activity [
21], but none of these mechanisms have been completely elucidated [
22,
23]. Consequently clinicians must rely on observable characteristics of labor to define its onset.
To clarify concepts surrounding the definition of onset of the latent and active phases of labor, and to determine what, if any, scientific rationale these definitions are based on, we performed a systematic review of the literature. Our review asks: 1) Among healthy women laboring spontaneously, how is the onset of the latent phase and the active phase of labor defined?; and 2) What, if any, evidentiary basis is provided by authors to support their definitions of labor onset?
Methods
Search methods
We searched for English, French or German-language original research papers published from 1978 to March 2014 that examined onset of the latent and active phases of the first stage of labor. The starting date of this search was chosen to reflect the publication date of the second and most recent edition of Friedman’s seminal book on the topic entitled “Labor: Clinical Evaluation and Management” [
15]. We followed the PRISMA statement for reporting, although we declined to undertake risk of bias assessment as it was not pertinent to our research question, and no review protocol exists for this study.
We sought original research that defined or operationalized the onset of latent labor and/or active labor in a population of healthy women with term births. To focus on healthy women, we excluded studies that specifically focused on cohorts of women with health conditions in labor (e.g., women with gestational diabetes, gestational hypertension, or obesity). In order to identify appropriate studies an information specialist (DG) searched the following electronic databases: CINAHL, EMBASE, MEDLINE, the Web of Science, and Evidence-Based Medicine Reviews (which incorporates ACP Journal Club, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Database of Abstracts of Review of Effectiveness, Health Technology Assessment and NHS Economic Evaluation Database). We also traced citations to and from relevant articles, and searched our personal libraries for additional articles. As we were primarily interested in understanding how studies were defining the onset of labor, we searched databases using subject heading and key words clustered around the concepts of latent and active phase of labor onset or onset of the first stage of labor overall. See Appendix 1 for the full electronic search strategy for each database. No review protocol was published for this study.
Study selection
We included studies of healthy women in uncomplicated labor at term written in English, French or German. In order to be eligible for inclusion, studies were required to be original, empirical research, and a study outcome must have involved labor onset or duration of labor. We excluded studies that focused exclusively on women with induced labor (although populations that included some women with induced labor were included), as well as case-studies, case-series and studies that did not present any original data (such as commentaries and reviews).
Papers were screened without blinding through a sequence of title (by SM and GH), and abstract (by SM and GH), and any discrepancies were resolved through discussion and agreement. If agreement could not be reached, a third screener (PJ) made the final decision [
24]. A larger group conducted full text review (SM, GH, PJ, MG, HS, and VH). Each paper was reviewed by one of the original screeners (SM, GH and PJ) as well as a second screener (MG, HS and VH). Discrepancies were resolved by one of the original screeners (SM, GH and PJ) who had not read the full text of the article. Screeners did not screen or extract articles they had authored or coauthored [
24].
Data extraction and analysis
A standardized data extraction form was developed [
24] to include details about the study design, setting, time period, and the inclusion and exclusion criteria used to define the study population, as well as information about the sample size, the intervention(s) of interest, and the outcome(s) of interest. Finally the reviewers independently extracted the definition of labor onset used according to whether it defined the onset of the latent, or active phase of labor or simply the onset of the first stage of labor. In addition, the reviewers extracted information about whether, and what, rationale the authors provided regarding their choice of definition of labor onset, including supporting citations.
Prior to beginning data extraction, all six full text reviewers independently piloted the standardized data extraction form on a random sample of three of the included studies [
24]. Responses were compared for discrepancies and all reviewers were involved in revising the data extraction form to ensure consistency and improve data quality. Once the form was finalized, full text reviewers (SM, GH, PJ, MG, HS, and VH) independently extracted data from the studies. Each study was extracted by two reviewers including one of the original screeners (SM, GH, and PJ). We did not contact any study authors for data confirmation. As our primary interest was the definition of labor onset, rather than the validity of the conclusion or the study outcomes, we did not assess risk of bias in our included studies.
Synthesis of results
We examined key aspects of the included studies, including study design, research objective, sample size, country of origin, years of data, and publication year, and constructed tables and figures to illustrate key findings. We also assessed differences in labor definitions according to parity.
Discussion
This systematic review provides an overview of how labor onset for healthy women is defined in the research literature and summarizes the evidence being used to support these definitions. We found studies providing definitions for four different types of labor onset; latent phase, active phase, first stage and unspecified labor. All four definitions commonly referenced cervical dilatation, cervical effacement, and uterine contractions, with little mention of other physiologic indications, such as bloody show and gastrointestinal symptoms. Cervical dilatation and regular painful contractions were the most common indicators of labor onset, regardless of stage or phase. However, there was little consensus on the degree of dilatation or regularity of contractions, even within definitions for the same stage or phase. The majority of included studies (60 %) did not provide any evidentiary basis for their definition of labor onset. Among studies that did provide evidence for their definition, the most common was a citation of Friedman’s labor curve.
We report that there is considerable discrepancy in definitions of labor onset in the research literature. Even among studies referencing the same type of labor onset (e.g., active phase labor) and indication of labor onset, there was little consensus, with the exception that 100 % of definitions of latent phase labor referenced the presence of regular painful contractions. This lack of consistency may be driven in part by the lack of standardized documentation of labor onset in the patient’s medical record. The lack of consistent documentation may both contribute to and result from the lack of a standardized definition. This discrepancy in definitions is also not surprising given that the physiologic mechanisms that stimulate the transition of uterine muscle from quiescence to regular contractions occur over a period of time, and on multiple levels, none of which are observable, and none of which yield clear biologic markers which would permit a definitive diagnosis of labor onset. The process of parturition begins days or weeks prior to the onset of observable labor. Placental estrogens, relaxin, and prostglandins ‘soften’ the collagen fibers in the cervix and make it more distensible [
90]. Under the influence of estrogen, prostaglandins and distension of uterine tissue, uterine tissue is prepared for labor through cell multiplication and hypertrophy. Uterotropins, including oxytocin, raise levels of intracellular calcium, which stimulates contractions. Oxytocin secreted by the fetus also is a major contributor to increasing oxytocin levels in uterine tissue [
91]. Oxytocin receptors increase in numbers in uterine muscle under the influence of estradiol as term approaches. Also under the influence of estrogens, the number of gap junctions in muscles increase. Gap junctions are transcellular membrane channels, which allow ion exchange between cells to propagate an electrical signal and subsequent muscle contraction [
90].
A definition of labor onset that uses both endocrine levels and observable signs and symptoms might provide a reliable and valid measure at some point in the future. In practical terms, what is needed is a point in time after which labor should not only be expected to continue among healthy women, but beyond which, failure to progress would require intervention on the part of the caregiver to prevent subsequent maternal and neonatal morbidity.
Studies in our review were more likely to focus on active phase of labor than latent phase labor, which is of concern given the adverse outcomes associated with early hospital admission in latent phase labor [
2,
3,
30]. A strong consensus around the definition of onset of latent phase labor is needed to ensure comparability of research findings, and subsequently to guide clinical diagnosis and intervention. Understanding when the transition between the latent and active phases of labor takes places is essential for designing initiatives to assist women to remain out of hospital during latent phase labor [
92].
Our review supports the notion that measurement of cervical dilatation is dominant in the discussion of determining labor onset and the transition from latent to active phases [
76]. Thus it is perhaps not surprising that women present to hospital when not in labor, as they are generally unable to assess their own cervical dilatation. Previous research has illustrated that descriptions of labor onset and progression that rely on cervical dilatation do not provide women with the means to understand how far they have progressed in their labor [
76]. While healthcare providers may feel relatively certain about their diagnosis when women arrive at hospital prior to active labor, they are then faced with making a management decision that incorporates not only their diagnostic judgment but also cues regarding how well the woman is coping, family expectations, and institutional requirements. These factors may contribute to admission in latent phase labor [
93].
A consistent and measurable definition of labor onset for each phase and stage is essential in order to identify departures from normal labor trajectories and avoid misdiagnosis of the onset of labor with subsequent sequelae, including increased risk for oxytocin augmentation of labor, caesarean section, meconium staining in the amniotic fluid, 5-min Apgar score less than 7, need for newborn resuscitation and admission to the NICU [
2,
3]. Definitions tend to be static, for example a measure of the cervical dilatation at which a phase or stage of labor is considered to have begun (e.g., active labor begins at 4 cm), or a degree of effacement. These static definitions may result from the widely held, and erroneous [
84] conclusion that Friedman defined the transition from latent to active phase labor as occurring at 3–4 cm cervical dilatation [
94,
95]. Friedman asserts instead that slow labor progression is identified by change in dilatation over time with active-phase cervical dilatation progressing linearly at a minimum of 1.0 cm/h in nulliparas [
84]. Recent recommendations have changed the cervical dilatation upon which the transition is believed to take place to 6 cm [
20]. Our systematic review has revealed that there appears to be little consensus in the amount of cervical dilatation necessary to indicate that active phase labor has begun.
Strengths of our systematic review include explicit, and detailed eligibility criteria and a comprehensive search constructed and conducted by an information specialist. We were also able to review studies published in English, French and German due to the multi-lingual capacity of our international team. A limitation of our review is that we cannot recommend a specific definition of labor. Given that our review sought simply to answer what definitions were in common use in the literature and what evidentiary basis was provided for their use, we were unable to assess whether specific definitions were associated with better obstetric outcomes than others. This is the type of research that will be needed to recommend a definition of labor onset. Further research seeking practitioners’ views on the most useful definition of onset of early labor would also be useful.
Competing interests
The authors declare they have no competing interests.
Authors’ contributions
GEH and PAJ drafted the review protocol and designed the review. DG completed all literature searching. GEH, SM, and PAJ competed the title and abstract reviews. GEH, SM, MG, VH, HS and PAJ completed the full text review. GEH drafted the data extraction form and SM, MG, VH, HS and PAJ reviewed and refined the data extraction form. SM completed the analysis. GEH drafted the article. All authors edited and revised the article. All authors read and approved the final manuscript.