Skip to main content
Erschienen in: Japanese Journal of Radiology 12/2016

07.10.2016 | Original Article

Diagnosis of early colorectal cancer invasion depth by quantitative evaluation of the basal indentation in CT colonography

verfasst von: Mitsutoshi Miyasaka, Daisuke Tsurumaru, Yusuke Nishimuta, Yoshiki Asayama, Satoshi Kawanami, Eiji Oki, Minako Hirahashi, Hiroshi Honda

Erschienen in: Japanese Journal of Radiology | Ausgabe 12/2016

Einloggen, um Zugang zu erhalten

Abstract

Objective

To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)—i.e., the intestinal lateral deformity—in CT colonography (CTC).

Materials and methods

34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i.e., the “BI ratio”) for each lesion. The BI ratios of the Tis and T1 CRCs were compared.

Results

The BI ratios were significantly higher in the T1 CRCs than in the Tis CRCs (p < 0.0001). The optimum cutoff value of the BI ratio for differentiating the T1 CRCs from the Tis CRCs was 1.64, with a sensitivity, specificity, and area under the curve of 90.5 %, 100 %, and 0.974, respectively.

Conclusions

We have demonstrated for the first time that quantitatively evaluating the BI can improve the accuracy of diagnosis of early CRC invasion depth.
Literatur
1.
Zurück zum Zitat Glasgow SC, Bleier JI, Burgart LJ, Finne CO, Lowry AC. Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2012;16:1019–28.CrossRef Glasgow SC, Bleier JI, Burgart LJ, Finne CO, Lowry AC. Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2012;16:1019–28.CrossRef
2.
3.
Zurück zum Zitat Kawamura YJ, Sakuragi M, Togashi K, Okada M, Nagai H, Konishi F. Distribution of lymph node metastasis in T1 sigmoid colon carcinoma: should we ligate the inferior mesenteric artery? Scand J Gastroenterol. 2005;40:858–61.CrossRefPubMed Kawamura YJ, Sakuragi M, Togashi K, Okada M, Nagai H, Konishi F. Distribution of lymph node metastasis in T1 sigmoid colon carcinoma: should we ligate the inferior mesenteric artery? Scand J Gastroenterol. 2005;40:858–61.CrossRefPubMed
4.
Zurück zum Zitat Wang HS, Liang WY, Lin TC, et al. Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Dis Colon Rectum. 2005;48:1182–92.CrossRefPubMed Wang HS, Liang WY, Lin TC, et al. Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Dis Colon Rectum. 2005;48:1182–92.CrossRefPubMed
5.
Zurück zum Zitat Kitajima K, Fujimori T, Fujii S, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol. 2004;39:534–43.CrossRefPubMed Kitajima K, Fujimori T, Fujii S, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol. 2004;39:534–43.CrossRefPubMed
6.
Zurück zum Zitat Ushio K, Goto H, Matsumura Y, Takayasu K, Moriyama N, Matue H. Significance of the profile view in the X-ray diagnosis of cancer of the digestive tract. Stomach Intest. 1986;21:27–41. Ushio K, Goto H, Matsumura Y, Takayasu K, Moriyama N, Matue H. Significance of the profile view in the X-ray diagnosis of cancer of the digestive tract. Stomach Intest. 1986;21:27–41.
7.
Zurück zum Zitat Ament AE, Alfidi RJ. Sessile polyps: analysis of radiographic projections with the aid of a double-contrast phantom. AJR Am J Roentgenol. 1982;139:111–4.CrossRefPubMed Ament AE, Alfidi RJ. Sessile polyps: analysis of radiographic projections with the aid of a double-contrast phantom. AJR Am J Roentgenol. 1982;139:111–4.CrossRefPubMed
8.
Zurück zum Zitat Ament AE, Alfidi RJ, Rao PS. Basal indentation of sessile polypoid lesions: a function of geometry rather than a sign of malignancy. Radiology. 1982;143:341–4.CrossRefPubMed Ament AE, Alfidi RJ, Rao PS. Basal indentation of sessile polypoid lesions: a function of geometry rather than a sign of malignancy. Radiology. 1982;143:341–4.CrossRefPubMed
9.
Zurück zum Zitat Maruyama M, Koizumi K, Kai S, Kazami A, Handa T. Radiographic diagnosis of early colorectal cancer, with special reference to the superficial type of invasive carcinoma. World J Surg. 2000;24:1036–46.CrossRefPubMed Maruyama M, Koizumi K, Kai S, Kazami A, Handa T. Radiographic diagnosis of early colorectal cancer, with special reference to the superficial type of invasive carcinoma. World J Surg. 2000;24:1036–46.CrossRefPubMed
10.
Zurück zum Zitat Ott DJ, Gelfand DW, Wu WC, Ablin DS. Colon polyp morphology on double-contrast barium enema: its pathologic predictive value. AJR Am J Roentgenol. 1983;141:965–70.CrossRefPubMed Ott DJ, Gelfand DW, Wu WC, Ablin DS. Colon polyp morphology on double-contrast barium enema: its pathologic predictive value. AJR Am J Roentgenol. 1983;141:965–70.CrossRefPubMed
11.
Zurück zum Zitat Watari J, Saitoh Y, Obara T, et al. Early nonpolypoid colorectal cancer: radiographic diagnosis of depth of invasion. Radiology. 1997;205:67–74.CrossRefPubMed Watari J, Saitoh Y, Obara T, et al. Early nonpolypoid colorectal cancer: radiographic diagnosis of depth of invasion. Radiology. 1997;205:67–74.CrossRefPubMed
12.
Zurück zum Zitat Sato T, Sakai Y, Kadowaki K, et al. Radio-geometric consideration of basal indentation using phantoms and specimens. Rinsho Hoshasen. 1989;34:1555–61. Sato T, Sakai Y, Kadowaki K, et al. Radio-geometric consideration of basal indentation using phantoms and specimens. Rinsho Hoshasen. 1989;34:1555–61.
13.
Zurück zum Zitat Campillo-Soto A, Pellicer-Franco E, Parlorio-Andres E, Soria-Aledo V, Morales-Cuenca G, Aguayo-Albasini JL. CT colonography vs. barium enema for the preoperative study of colorectal cancer in patients with incomplete colonoscopy. Med Clin. 2007;129:725–8.CrossRef Campillo-Soto A, Pellicer-Franco E, Parlorio-Andres E, Soria-Aledo V, Morales-Cuenca G, Aguayo-Albasini JL. CT colonography vs. barium enema for the preoperative study of colorectal cancer in patients with incomplete colonoscopy. Med Clin. 2007;129:725–8.CrossRef
14.
Zurück zum Zitat Neri E, Giusti P, Battolla L, et al. Colorectal cancer: role of CT colonography in preoperative evaluation after incomplete colonoscopy. Radiology. 2002;223:615–9.CrossRefPubMed Neri E, Giusti P, Battolla L, et al. Colorectal cancer: role of CT colonography in preoperative evaluation after incomplete colonoscopy. Radiology. 2002;223:615–9.CrossRefPubMed
15.
Zurück zum Zitat Neri E, Turini F, Cerri F, et al. Comparison of CT colonography vs. conventional colonoscopy in mapping the segmental location of colon cancer before surgery. Abdom Imaging. 2010;35:589–95.CrossRefPubMed Neri E, Turini F, Cerri F, et al. Comparison of CT colonography vs. conventional colonoscopy in mapping the segmental location of colon cancer before surgery. Abdom Imaging. 2010;35:589–95.CrossRefPubMed
16.
Zurück zum Zitat Stabile Ianora AA, Moschetta M, Pedote P, Scardapane A, Angelelli G. Preoperative local staging of colosigmoideal cancer: air versus water multidetector-row CT colonography. La Radiol Med. 2012;117:254–67.CrossRef Stabile Ianora AA, Moschetta M, Pedote P, Scardapane A, Angelelli G. Preoperative local staging of colosigmoideal cancer: air versus water multidetector-row CT colonography. La Radiol Med. 2012;117:254–67.CrossRef
17.
Zurück zum Zitat Utano K, Endo K, Togashi K, et al. Preoperative T staging of colorectal cancer by CT colonography. Dis Colon Rectum. 2008;51:875–81.CrossRefPubMed Utano K, Endo K, Togashi K, et al. Preoperative T staging of colorectal cancer by CT colonography. Dis Colon Rectum. 2008;51:875–81.CrossRefPubMed
18.
Zurück zum Zitat Filippone A, Ambrosini R, Fuschi M, Marinelli T, Genovesi D, Bonomo L. Preoperative T and N staging of colorectal cancer: accuracy of contrast-enhanced multi-detector row CT colonography—initial experience. Radiology. 2004;231:83–90. Filippone A, Ambrosini R, Fuschi M, Marinelli T, Genovesi D, Bonomo L. Preoperative T and N staging of colorectal cancer: accuracy of contrast-enhanced multi-detector row CT colonography—initial experience. Radiology. 2004;231:83–90.
19.
Zurück zum Zitat Kayashima Y, Kimura F, Inoue K, Honda Y, Nakanishi T, Ito K. Computed tomographic air-contrast enema imaging for presurgical examination of colon tumors: assessment with colon phantoms and in patients. Radiat Med. 2008;26:6–14.CrossRefPubMed Kayashima Y, Kimura F, Inoue K, Honda Y, Nakanishi T, Ito K. Computed tomographic air-contrast enema imaging for presurgical examination of colon tumors: assessment with colon phantoms and in patients. Radiat Med. 2008;26:6–14.CrossRefPubMed
20.
Zurück zum Zitat Nagata K, Endo S, Kudo SE, Kitanosono T, Kushihashi T. CT air-contrast enema as a preoperative examination for colorectal cancer. Dig Surg. 2004;21:352–8.CrossRefPubMed Nagata K, Endo S, Kudo SE, Kitanosono T, Kushihashi T. CT air-contrast enema as a preoperative examination for colorectal cancer. Dig Surg. 2004;21:352–8.CrossRefPubMed
21.
Zurück zum Zitat Miyasaka M, Ueda M, Muraki T, et al. Basal indentation due to a function of geometry on CT air-contrast enema for sessile colorectal polyps: quantitative evaluation using cross-sectional multiplanar reconstruction. J Radiol Radiat Ther. 2014;2:1050. Miyasaka M, Ueda M, Muraki T, et al. Basal indentation due to a function of geometry on CT air-contrast enema for sessile colorectal polyps: quantitative evaluation using cross-sectional multiplanar reconstruction. J Radiol Radiat Ther. 2014;2:1050.
22.
Zurück zum Zitat Participants in the Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc. 2003;58:S3–43. Participants in the Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc. 2003;58:S3–43.
23.
Zurück zum Zitat Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours, 7th edn. Chichester: Wiley-Blackwell; 2009. Sobin LH, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours, 7th edn. Chichester: Wiley-Blackwell; 2009.
24.
Zurück zum Zitat Dawson B, Trapp RG. Basic and clinical biostatistics, 4th edn. New York: Lange Medical Books/McGraw–Hill; 2004. Dawson B, Trapp RG. Basic and clinical biostatistics, 4th edn. New York: Lange Medical Books/McGraw–Hill; 2004.
25.
Zurück zum Zitat Matsumoto T, Esaki M, Hizawa K, et al. Accuracy of radiographic assessment for the diagnosis of invasion depth in small invasive colorectal cancer. Br J Radiol. 2003;76:611–6.CrossRefPubMed Matsumoto T, Esaki M, Hizawa K, et al. Accuracy of radiographic assessment for the diagnosis of invasion depth in small invasive colorectal cancer. Br J Radiol. 2003;76:611–6.CrossRefPubMed
26.
Zurück zum Zitat Fuchigami T, Iwashita A, Hirakawa M, et al. Diagnosis from the radiographic standpoint of submucosal cancer of the colon. Stomach Intest. 1991;26:737–49. Fuchigami T, Iwashita A, Hirakawa M, et al. Diagnosis from the radiographic standpoint of submucosal cancer of the colon. Stomach Intest. 1991;26:737–49.
27.
Zurück zum Zitat Mukae M, Kobayashi K, Sada M, Yokoyama K, Koizumi W, Saegusa M. Diagnostic performance of EUS for evaluating the invasion depth of early colorectal cancers. Gastrointest Endosc. 2015;81:682–90.CrossRefPubMed Mukae M, Kobayashi K, Sada M, Yokoyama K, Koizumi W, Saegusa M. Diagnostic performance of EUS for evaluating the invasion depth of early colorectal cancers. Gastrointest Endosc. 2015;81:682–90.CrossRefPubMed
Metadaten
Titel
Diagnosis of early colorectal cancer invasion depth by quantitative evaluation of the basal indentation in CT colonography
verfasst von
Mitsutoshi Miyasaka
Daisuke Tsurumaru
Yusuke Nishimuta
Yoshiki Asayama
Satoshi Kawanami
Eiji Oki
Minako Hirahashi
Hiroshi Honda
Publikationsdatum
07.10.2016
Verlag
Springer Japan
Erschienen in
Japanese Journal of Radiology / Ausgabe 12/2016
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-016-0586-7

Weitere Artikel der Ausgabe 12/2016

Japanese Journal of Radiology 12/2016 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.