Working memory disturbances are a frequently replicated finding in schizophrenia and less consistent also in schizoaffective disorder. Working memory dysfunctions have been shown to be heritable and have been proposed to represent a promising endophenotype of schizophrenic psychoses.
In the present study, we investigated the effects of familial loading on performance rates in circuit-specific verbal and visuospatial working memory tasks in matched samples of schizophrenic patients (from multiply affected or uniaffected families), schizoaffective patients (from multiply affected or uniaffected families), and healthy subjects.
We found a significant interaction effect between familial loading and diagnosis in terms of a diagnosis-specific detrimental effect of familial loading on the performance of schizophrenic (but not schizoaffective) patients in the articulatory rehearsal task.
This finding of a circuit-specific verbal working memory deficit in schizophrenic patients with additional familial loading is consistent with prior studies, which provided evidence for the existence of specific subgroups of schizophrenic patients with selective working memory impairments and for diagnosis-specific dysfunctions of the articulatory rehearsal mechanism in schizophrenic, but not in schizoaffective patients. Together, these findings suggest that the genetic risk for (a subtype of) schizophrenia may be associated with dysfunctions of the brain system, which underlies the articulatory rehearsal mechanism, the probably phylogenetically youngest part of human working memory.
Barrantes-Vidal N, Aguilera M, Campanera S, Fatjó-Vilas M, Guitart M, Miret S, Valero S, Fañanás L (2007) Working memory in siblings of schizophrenia patients. Schizophr Res 95:76–85 CrossRef
Evans JD, Heaton RK, Paulsen JS, McAdams LA, Heaton SC, Jeste DV (1999) Schizoaffective disorder: a form of schizophrenia or affective disorder? J Clin Psychiatry 60:874–882 PubMed
Forbes NF, Carrick LA, McIntosh AM, Lawrie SM (2008) Working memory in schizophrenia: a meta-analysis. Psychol Med 2008 Oct 23:1–17 [Epub ahead of print]
Gruber O, Goschke T (2004) Executive control emerging from dynamic interactions between brain systems mediating language, working memory and attentional processes. Acta Psychol 115:105–121 CrossRef
Spellmann I, Müller N, Musil R, Zill P, Douhet A, Dehning S, Cerovecki A, Bondy B, Möller HJ, Riedel M (2008) Associations of SNAP-25 polymorphisms with cognitive dysfunctions in Caucasian patients with schizophrenia during a brief trail of treatment with atypical antipsychotics. Eur Arch Psychiatry Clin Neurosci 258:335–344 PubMedCrossRef
Zilles D, Gruber E, Falkai P, Gruber O (2005) Funktionelle Integrität neuronaler Netzwerke mit Arbeitsgedächtnisfunktion bei schizophrenen Psychosen. Nervenarzt 76(S1):S33–S34
- Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia
- D. Steinkopff-Verlag
European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491