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Erschienen in: Zeitschrift für Rheumatologie 9/2016

25.12.2015 | Originalien

Diagnostic accuracy of 18F-FDG PET or PET/CT for large vessel vasculitis

A meta-analysis

verfasst von: Y.H. Lee, MD, PhD, S.J. Choi, J.D. Ji, G.G. Song

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 9/2016

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Abstract

Objective

The purpose of this study was to evaluate the diagnostic performance of 18F-fluorodeoxyglucose positron-emission tomography (18F-FDG PET) or positron-emission tomography/computed tomography (PET/CT) for patients with large vessel vasculitis.

Methods

Based on a search in the PubMed, Embase, and Cochrane Library databases, a meta-analysis was performed on the diagnostic accuracy of 18F-FDG PET or PET/CT in patients with large vessel vasculitis.

Results

A total of eight studies involving 400 subjects (170 vasculitis patients and 230 controls) were selected for meta-analysis. The pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 75.9 % (95 % confidence interval, CI 68.7–82.1) and 93.0 % (95 % CI 88.9–96.0), respectively. The positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were 7.267 (95 % CI 3.707–14.24), 0.303 (95 % CI 0.229–0.400), and 32.04 (95 % CI 13.08–78.45), respectively. The area under the curve (AUC) was 0.863 and the Q* index 0.794, indicating good diagnostic accuracy. There was no evidence of a threshold effect (Spearman’s correlation coefficient = 0.120, p = 0.776). When the data were limited to giant cell arteritis (GCA), the pooled sensitivity and specificity of 18F-FDG PET or PET/CT were 83.3 % (95 % CI 72.1–91.4) and 89.6 % (95 % CI 79.7–95.7), respectively; AUC was 0.884, and the Q* index 0.815, indicating modest accuracy with a small increase in diagnostic accuracy.

Conclusion

This meta-analysis of published studies demonstrates that 18F-FDG PET or PET/CT has good diagnostic accuracy for large vessel vasculitis and plays an important role in the diagnosis of this condition.
Literatur
2.
Zurück zum Zitat Hunder GG, Bloch DA, Michel BA et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33(8):1122–1128CrossRefPubMed Hunder GG, Bloch DA, Michel BA et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33(8):1122–1128CrossRefPubMed
3.
Zurück zum Zitat Arend WP, Michel BA, Bloch DA et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum33(8):1129–1134 Arend WP, Michel BA, Bloch DA et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum33(8):1129–1134
4.
Zurück zum Zitat Mukhtyar C, Guillevin L, Cid MC et al (2009) EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis 68(3):318–323CrossRefPubMed Mukhtyar C, Guillevin L, Cid MC et al (2009) EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis 68(3):318–323CrossRefPubMed
6.
Zurück zum Zitat Ishimori T, Saga T, Mamede M et al (2002) Increased 18F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med 43(5):658–663PubMed Ishimori T, Saga T, Mamede M et al (2002) Increased 18F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med 43(5):658–663PubMed
7.
Zurück zum Zitat Weber WA, Grosu AL, Czernin J (2008) Technology Insight: advances in molecular imaging and an appraisal of PET/CT scanning. Nat Clin Pract Oncol 5(3):160–170CrossRefPubMed Weber WA, Grosu AL, Czernin J (2008) Technology Insight: advances in molecular imaging and an appraisal of PET/CT scanning. Nat Clin Pract Oncol 5(3):160–170CrossRefPubMed
8.
Zurück zum Zitat Belhocine T, Blockmans D, Hustinx R et al (2003) Imaging of large vessel vasculitis with 18FDG PET: illusion or reality? A critical review of the literature data. Eur J Nucl Med Mol Imaging 30(9):1305–1313CrossRefPubMed Belhocine T, Blockmans D, Hustinx R et al (2003) Imaging of large vessel vasculitis with 18FDG PET: illusion or reality? A critical review of the literature data. Eur J Nucl Med Mol Imaging 30(9):1305–1313CrossRefPubMed
9.
Zurück zum Zitat Zerizer I, Tan K, Khan S et al (2010) Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis. Eur J Radiol 73(3):504–509CrossRefPubMed Zerizer I, Tan K, Khan S et al (2010) Role of FDG-PET and PET/CT in the diagnosis and management of vasculitis. Eur J Radiol 73(3):504–509CrossRefPubMed
10.
Zurück zum Zitat Besson FL, Boysson H de, Parienti JJ et al (2014) Towards an optimal semiquantitative approach in giant cell arteritis: an (18)F-FDG PET/CT case-control study. Eur J Nucl Med Mol Imaging 41(1):155–166CrossRefPubMed Besson FL, Boysson H de, Parienti JJ et al (2014) Towards an optimal semiquantitative approach in giant cell arteritis: an (18)F-FDG PET/CT case-control study. Eur J Nucl Med Mol Imaging 41(1):155–166CrossRefPubMed
11.
Zurück zum Zitat Prieto-Gonzalez S, Depetris M, Garcia-Martinez A et al (2014) Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study. Ann Rheum Dis 73(7):1388–1392CrossRefPubMed Prieto-Gonzalez S, Depetris M, Garcia-Martinez A et al (2014) Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study. Ann Rheum Dis 73(7):1388–1392CrossRefPubMed
12.
Zurück zum Zitat Lehmann P, Buchtala S, Achajew N et al (2011) 18F-FDG PET as a diagnostic procedure in large vessel vasculitis-a controlled, blinded re-examination of routine PET scans. Clin Rheumatol 30(1):37–42CrossRefPubMed Lehmann P, Buchtala S, Achajew N et al (2011) 18F-FDG PET as a diagnostic procedure in large vessel vasculitis-a controlled, blinded re-examination of routine PET scans. Clin Rheumatol 30(1):37–42CrossRefPubMed
13.
Zurück zum Zitat Fuchs M, Briel M, Daikeler T et al (2012) The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis. Eur J Nucl Med Mol Imaging 39(2):344–353CrossRefPubMed Fuchs M, Briel M, Daikeler T et al (2012) The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis. Eur J Nucl Med Mol Imaging 39(2):344–353CrossRefPubMed
14.
Zurück zum Zitat Hautzel H, Sander O, Heinzel A et al (2008) Assessment of large-vessel involvement in giant cell arteritis with 18F-FDG PET: introducing an ROC-analysis-based cutoff ratio. J Nucl Med 49(7):1107–1113CrossRefPubMed Hautzel H, Sander O, Heinzel A et al (2008) Assessment of large-vessel involvement in giant cell arteritis with 18F-FDG PET: introducing an ROC-analysis-based cutoff ratio. J Nucl Med 49(7):1107–1113CrossRefPubMed
15.
Zurück zum Zitat Walter MA, Melzer RA, Schindler C et al (2005) The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease. Eur J Nucl Med Mol Imaging 32(6):674–681CrossRefPubMed Walter MA, Melzer RA, Schindler C et al (2005) The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease. Eur J Nucl Med Mol Imaging 32(6):674–681CrossRefPubMed
16.
Zurück zum Zitat Meller J, Strutz F, Siefker U et al (2003) Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI. Eur J Nucl Med Mol Imaging 30(5):730–736CrossRefPubMed Meller J, Strutz F, Siefker U et al (2003) Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI. Eur J Nucl Med Mol Imaging 30(5):730–736CrossRefPubMed
17.
Zurück zum Zitat Henes JC, Muller M, Krieger J et al (2008) [18F] FDG-PET/CT as a new and sensitive imaging method for the diagnosis of large vessel vasculitis. Clin Exp Rheumatol 26(3 Suppl 49):S47–S52PubMed Henes JC, Muller M, Krieger J et al (2008) [18F] FDG-PET/CT as a new and sensitive imaging method for the diagnosis of large vessel vasculitis. Clin Exp Rheumatol 26(3 Suppl 49):S47–S52PubMed
18.
Zurück zum Zitat Song GG, Lee YH (2014) Diagnostic accuracies of sialography and salivary ultrasonography in Sjogren’s syndrome patients: a meta-analysis. Clin Exp Rheumatol 32(4):516–522PubMed Song GG, Lee YH (2014) Diagnostic accuracies of sialography and salivary ultrasonography in Sjogren’s syndrome patients: a meta-analysis. Clin Exp Rheumatol 32(4):516–522PubMed
19.
Zurück zum Zitat Lee YH, Rho YH, Choi SJ et al (2007) PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 27(9):827–833CrossRefPubMed Lee YH, Rho YH, Choi SJ et al (2007) PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 27(9):827–833CrossRefPubMed
20.
Zurück zum Zitat Nath SK, Harley JB, Lee YH (2005) Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 118(2):225–234CrossRefPubMed Nath SK, Harley JB, Lee YH (2005) Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 118(2):225–234CrossRefPubMed
21.
Zurück zum Zitat Whiting P, Rutjes AW, Reitsma JB et al (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25CrossRefPubMedPubMedCentral Whiting P, Rutjes AW, Reitsma JB et al (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558CrossRefPubMed Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558CrossRefPubMed
24.
Zurück zum Zitat DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed
25.
Zurück zum Zitat Lijmer JG, Bossuyt PM, Heisterkamp SH (2002) Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Stat Med 21(11):1525–1537CrossRefPubMed Lijmer JG, Bossuyt PM, Heisterkamp SH (2002) Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Stat Med 21(11):1525–1537CrossRefPubMed
27.
Zurück zum Zitat Besson FL, Parienti JJ, Bienvenu B et al (2011) Diagnostic performance of (1)(8)F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 38(9):1764–1772CrossRefPubMed Besson FL, Parienti JJ, Bienvenu B et al (2011) Diagnostic performance of (1)(8)F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 38(9):1764–1772CrossRefPubMed
28.
Zurück zum Zitat Cheng Y, Lv N, Wang Z et al (2013) 18-FDG-PET in assessing disease activity in Takayasu arteritis: a meta-analysis. Clin Exp Rheumatol 31(1 Suppl 75):S22–S27PubMed Cheng Y, Lv N, Wang Z et al (2013) 18-FDG-PET in assessing disease activity in Takayasu arteritis: a meta-analysis. Clin Exp Rheumatol 31(1 Suppl 75):S22–S27PubMed
29.
Zurück zum Zitat Luqmani RA, Suppiah R, Grayson PC et al (2011) Nomenclature and classification of vasculitis – update on the ACR/EULAR diagnosis and classification of vasculitis study (DCVAS). Clin Expe Immunol 164:11–13CrossRef Luqmani RA, Suppiah R, Grayson PC et al (2011) Nomenclature and classification of vasculitis – update on the ACR/EULAR diagnosis and classification of vasculitis study (DCVAS). Clin Expe Immunol 164:11–13CrossRef
30.
Zurück zum Zitat Guellec D, Cornec D, Jousse-Joulin S et al (2013) Diagnostic value of labial minor salivary gland biopsy for Sjogren’s syndrome: a systematic review. Autoimmun Rev 12(3):416–420CrossRefPubMed Guellec D, Cornec D, Jousse-Joulin S et al (2013) Diagnostic value of labial minor salivary gland biopsy for Sjogren’s syndrome: a systematic review. Autoimmun Rev 12(3):416–420CrossRefPubMed
Metadaten
Titel
Diagnostic accuracy of 18F-FDG PET or PET/CT for large vessel vasculitis
A meta-analysis
verfasst von
Y.H. Lee, MD, PhD
S.J. Choi
J.D. Ji
G.G. Song
Publikationsdatum
25.12.2015
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Rheumatologie / Ausgabe 9/2016
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI
https://doi.org/10.1007/s00393-015-1674-2

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