nach oben

World Journal of Urology

Erschienen in:

02.01.2018 | Original Article

Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis

verfasst von: Seong-Jang Kim, Phillip J. Koo, Kyoungjune Pak, In-Ju Kim, Keunyoung Kim

Erschienen in: World Journal of Urology | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Objective

We aimed to assess the diagnostic accuracy of C-11 choline and C-11 acetate positron emission tomography/computed tomography (PET/CT) for lymph node (LN) staging in bladder cancer (BC) patients through a systematic review and meta-analysis.

Methods

The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through June 30, 2017, were searched for studies evaluating the diagnostic performance of C-11 choline and C-11 acetate PET/CT for LN staging in BC. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR−), and constructed summary receiver operating characteristic curves.

Results

Across 10 studies (282 patients), the pooled sensitivity was 0.66 (95% CI 0.54–0.75) without heterogeneity (χ² = 12.4, p = 0.19) and a pooled specificity of 0.89 (95% CI 0.76–0.95) with heterogeneity (χ² = 29.1, p = 0.00). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 5.8 (95% CI 2.7–12.7) and negative likelihood ratio (LR−) of 0.39 (95% CI 0.28–0.53). The pooled diagnostic odds ratio (DOR) was 15 (95% CI 6–38). In meta-regression analysis, the study design (prospective vs retrospective) was the source of the study heterogeneity.

Conclusion

C-11 choline and C-11 acetate PET/CT shows a low sensitivity and moderate specificity for the detection of metastatic LNs in patients with BC. Moreover, heterogeneity among the studies should be considered a limitation. Further large multicenter studies would be necessary to substantiate the diagnostic accuracy of C-11 choline and C-11 acetate PET/CT for this purpose.

Siegel RL et al (2017) Cancer Statistics, 2017. CA Cancer J Clin 67(1):7–30CrossRefPubMed

Amin MB et al (2013) ICUD-EAU international consultation on bladder cancer 2012: pathology. Eur Urol 63(1):16–35CrossRefPubMed

Paik ML et al (2000) Limitations of computerized tomography in staging invasive bladder cancer before radical cystectomy. J Urol 163(6):1693–1696CrossRefPubMed

Herr HW et al (2007) Defining optimal therapy for muscle invasive bladder cancer. J Urol 177(2):437–443CrossRefPubMed

Stein JP et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19(3):666–675CrossRefPubMed

Nishiyama H et al (2004) Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990–2000 in Japan. Eur Urol 45(2):176–181CrossRefPubMed

Palmieri F et al (2010) Prognostic value of lymphovascular invasion in bladder cancer in patients treated with radical cystectomy. Anticancer Res 30(7):3–6

Zehnder P et al (2011) Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study. J Urol 186(4):1261–1268CrossRefPubMed

Schiavina R et al (2013) Perioperative complications and mortality after radical cystectomy when using a standardized reporting methodology. Clin Genitourin Cancer 11(2):189–197CrossRefPubMed

10.

Husband JE (1995) Computer tomography and magnetic resonance imaging in the evaluation of bladder cancer. J Belge Radiol 78(6):350–355PubMed

11.

Blodgett TM et al (2007) PET/CT: form and function. Radiology 242(2):360–385CrossRefPubMed

12.

Czernin J et al (2007) Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006. J Nucl Med 48(Suppl 1):78S–88SPubMed

13.

Kibel AS et al (2009) Prospective study of [¹⁸F] fluorodeoxyglucose positron emission tomography/computed tomography for staging of muscle-invasive bladder carcinoma. J Clin Oncol 27(26):4314–4320CrossRefPubMedPubMedCentral

14.

Lodde M et al (2010) Evaluation of fluorodeoxyglucose positron-emission tomography with computed tomography for staging of urothelial carcinoma. BJU Int 106(5):658–663CrossRefPubMed

15.

Swinnen G et al (2010) FDG-PET/CT for the preoperative lymph node staging of invasive bladder cancer. Eur Urol 57(4):641–647CrossRefPubMed

16.

Vind-Kezunovic S et al (2017) Detection of lymph node metastasis in patients with bladder cancer using maximum standardised uptake value and 18F-fluorodeoxyglucose positron emission tomography/computed tomography: results from a high-volume centre including long-term follow-up. Eur Urol Focus. https://doi.org/10.1016/j.euf.2017.06.005 (Epub ahead of print) PubMed

17.

Golan S et al (2011) Comparison of ¹¹C-choline with ¹⁸F-FDG in positron emission tomography/computerized tomography for staging urothelial carcinoma: a prospective study. J Urol 186(2):436–441CrossRefPubMed

18.

Vargas HA et al (2012) Prospective evaluation of MRI, ¹¹C-acetate PET/CT and contrast-enhanced CT for staging of bladder cancer. Eur J Radiol 81(12):4131–4137CrossRefPubMed

19.

Whiting PF et al (2011) QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155(8):529–536CrossRefPubMed

20.

Glas AS et al (2003) The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol 56(11):1129–1135CrossRefPubMed

21.

Thompson SG (1994) Why sources of heterogeneity in meta-analysis should be investigated. BMJ 309(6965):1351–1355CrossRefPubMedPubMedCentral

22.

Deeks JJ et al (2005) The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 58(9):882–893CrossRefPubMed

23.

Reitsma JB et al (2005) Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 58(10):982–990CrossRefPubMed

24.

Hamza TH et al (2008) The binomial distribution of meta-analysis was preferred to model within-study variability. J Clin Epidemiol 61(1):41–51CrossRefPubMed

25.

Rutter CM et al (2001) A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Stat Med 20(19):2865–2884CrossRefPubMed

26.

Lijmer JG et al (1999) Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 282(11):1061–1066CrossRefPubMed

27.

Brunocilla E et al (2014) Diagnostic accuracy of ¹¹C-choline PET/CT in preoperative lymph node staging of bladder cancer: a systematic comparison with contrast-enhanced CT and histologic findings. Clin Nucl Med 39(5):e308–e312CrossRefPubMed

28.

Ceci F et al (2015) ¹¹C-choline PET/CT and bladder cancer: lymph node metastasis assessment with pathological specimens as reference standard. Clin Nucl Med 40(2):e124–e128CrossRefPubMed

29.

Gofrit ON et al (2006) Contribution of ¹¹C-choline positron emission tomography/computerized tomography to preoperative staging of advanced transitional cell carcinoma. J Urol 176(3):940–944CrossRefPubMed

30.

de Jong IJ et al (2002) Visualisation of bladder cancer using ¹¹C-choline PET: first clinical experience. Eur J Nucl Med Mol Imaging 29(10):1283–1288CrossRefPubMed

31.

Graziani T et al (2015) ¹¹C-choline PET/CT for restaging of bladder cancer. Clin Nucl Med 40(1):e1–e5CrossRefPubMed

32.

Maurer T et al (2012) Diagnostic efficacy of [11C]choline positron emission tomography/computed tomography compared with conventional computed tomography in lymph node staging of patients with bladder cancer prior to radical cystectomy. Eur Urol 61(5):1031–1038CrossRefPubMed

33.

Picchio M et al (2006) Value of ¹¹C-choline PET and contrast-enhanced CT for staging of bladder cancer: correlation with histopathologic findings. J Nucl Med 47(6):938–944PubMed

34.

Schöder H et al (2012) Initial results with ¹¹C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer. Mol Imaging Biol 14(2):245–251CrossRefPubMed

35.

Treiber U et al (2005) Diagnostic efficacy of 11C-choline positron emission tomography in patients scheduled for cystectomy. Eur Urol Suppl 4(3):161CrossRef

36.

Brunocilla E et al (2011) The role of pelvic lymph node dissection during radical cystectomy for bladder cancer. Anticancer Res 31(1):271–275PubMed

37.

Shvarts O et al (2002) Positron emission tomography in urologic oncology. Cancer Control 9(4):335–342CrossRefPubMed

38.

Farsad M et al (2008) Positron-emission tomography in imaging and staging prostate cancer. Cancer Biomark 4(4–5):277–284CrossRefPubMed

39.

Nanni C et al (2013) Comparison of ¹⁸F-FACBC and ¹¹C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse: preliminary results. Eur J Nucl Med Mol Imaging 40(Suppl 1):S11–S17CrossRefPubMed

40.

Lu YY et al (2012) Clinical value of FDG PET or PET/CT in urinary bladder cancer: a systemic review and meta-analysis. Eur J Radiol 81(9):2411–2416CrossRefPubMed

41.

Kates AM et al (2003) Impact of aging on substrate metabolism by the human heart. J Am Coll Cardiol 41(2):293–299CrossRefPubMed

42.

Oyama N et al (2003) ¹¹C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse. J Nucl Med 44(4):549–555PubMed

43.

Sandblom G et al (2006) Positron emission tomography with C11-acetate for tumor detection and localization in patients with prostate-specific antigen relapse after radical prostatectomy. Urology 67(5):996–1000CrossRefPubMed

44.

Yoshimoto M et al (2001) Characterization of acetate metabolism in tumor cells in relation to cell proliferation: acetate metabolism in tumor cells. Nucl Med Biol 28(2):117–122CrossRefPubMed

45.

Vavere AL et al (2008) ¹¹C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. J Nucl Med 49(2):327–334CrossRefPubMed

46.

Menendez JA et al (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7(10):763–777CrossRefPubMed

47.

Brusselmans K et al (2005) RNA interference-mediated silencing of the acetyl-CoA-carboxylase alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 65(15):6719–6725CrossRefPubMed

48.

Boellaard R (2012) Mutatis mutandis: harmonize the standard! J Nucl Med 53(1):1–3CrossRefPubMed

49.

Boellaard R et al (2008) The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials. Eur J Nucl Med Mol Imaging 35(12):2320–2333CrossRefPubMed

Titel: Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis
verfasst von: Seong-Jang Kim
Phillip J. Koo
Kyoungjune Pak
In-Ju Kim
Keunyoung Kim
Publikationsdatum: 02.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 3/2018
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-017-2168-4

Neu im Fachgebiet Urologie

24.04.2024 | DGIM 2024 | Nachrichten

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Diagnostic accuracy of C-11 choline and C-11 acetate for lymph node staging in patients with bladder cancer: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusion

Neu im Fachgebiet Urologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Stufenschema weist Prostatakarzinom zuverlässig nach

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Varikozelen bei Jugendlichen: Das Für und Wider der Operation

Update Urologie

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2018

Trends in urinary diversion after radical cystectomy for urothelial carcinoma

Low-pressure monopolar electroresection of the prostate for glands sized > 70 vs. < 70 cc performed with continuous irrigation and suprapubic suction: perioperative and long-term outcome

The role of PSMA PET scans in salvage therapy planning

PSA response to cabazitaxel is associated with improved progression-free survival in metastatic castration-resistant prostate cancer: the non-interventional QoLiTime study

A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA ‘grey zone’

Robot-assisted extravesical ureteral reimplantation (revur) for unilateral vesico-ureteral reflux in children: results of a multicentric international survey

Neu im Fachgebiet Urologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Stufenschema weist Prostatakarzinom zuverlässig nach

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Varikozelen bei Jugendlichen: Das Für und Wider der Operation

Update Urologie