Background
Methods
Case selection and relevant immunohistochemistry in expert review
Fluorescence in situ hybridization
Histological type | Probe |
---|---|
Myxoid liposarcoma | DDIT3 Dual Color Break Apart Probe (Abbott Molecular Inc., IL) |
Synovial sarcoma | SS18 Dual Color Break Apart Probe (Abbott Molecular Inc.) |
Mesenchymal chondrosarcoma | HEY1-NCOA2 fusion probe (Chromosome Science Lab Inc., Sapporo, Japan) |
Extraskeletal Ewing sarcoma | EWSR1 Dual Color Break Apart Probe (Abbott Molecular Inc.) |
Clear cell sarcoma | |
Angiomatoid fibrous histiocytoma | |
Desmoplastic small round cell tumor | |
Alveolar soft part sarcoma | TFE3 split probe (Chromosome Science Lab Inc.) |
Alveolar rhabdomyosarcoma | FOXO1 Dual Color Break Apart Probe (Abbott Molecular Inc.) |
Extraskeletal myxoid chondrosarcoma | NR4A3 split probe (Chromosome Science Lab Inc.) |
Dermatofibrosarcoma protuberans | PDGFB split probe (Chromosome Science Lab Inc.) |
Angiomatoid fibrous histiocytoma | FUS Dual Color Break Apart Probe (Abbott Molecular Inc.) |
Results
Histological type | Study site | Expert review | FISH | ||
---|---|---|---|---|---|
Positive | Negative | ND | |||
Myxoid liposarcoma | 24 | 24 | 22 | 0 | 2 |
Synovial sarcoma | 21 | 18 | 16 | 4a
| 1b
|
Mesenchymal chondrosarcoma | 6 | 6 | 3 | 0 | 3 |
Extraskeletal Ewing sarcoma | 5 | 5 | 4 | 0 | 1 |
Alveolar soft part sarcoma | 5 | 5 | 5 | 0 | 0 |
Alveolar rhabdomyosarcoma | 5 | 5 | 4 | 1 | 0 |
Clear cell sarcoma | 5 | 5 | 5 | 0 | 0 |
Extraskeletal myxoid chondrosarcoma | 2 | 2 | 1 | 1 | 0 |
Dermatofibrosarcoma protuberans | 1 | 1 | 1 | 0 | 0 |
Angiomatoid fibrous histiocytoma | 1 | 1 | 1 | 0 | 0 |
Desmoplastic small round cell tumor | 1 | 1 | 1 | 0 | 0 |
Total | 76 | 73 | 63 | 6 | 7 |