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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 1/2010

01.01.2010 | Original Article

Diagnostic value of [18F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation

verfasst von: Niklas Jasper, Jan Däbritz, Michael Frosch, Markus Loeffler, Matthias Weckesser, Dirk Foell

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2010

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Abstract

Purpose

Fever of unknown origin (FUO) and unexplained signs of inflammation are challenging medical problems especially in children and predominantly caused by infections, malignancies or noninfectious inflammatory diseases. The aim of this study was to assess the diagnostic value of 18F-FDG PET and PET/CT in the diagnostic work-up in paediatric patients.

Methods

In this retrospective study, 47 FDG PET and 30 PET/CT scans from 69 children (median age 8.1 years, range 0.2–18.1 years, 36 male, 33 female) were analysed. The diagnostic value of PET investigations in paediatric patients presenting with FUO (44 scans) or unexplained signs of inflammation without fever (33 scans) was analysed.

Results

A diagnosis in paediatric patients with FUO or unexplained signs of inflammation could be established in 32 patients (54%). Of all scans, 63 (82%) were abnormal, and of the total number of 77 PET and PET/CT scans 35 (45%) were clinically helpful. In patients with a final diagnosis, scans were found to have contributed to the diagnosis in 73%. Laboratory, demographic or clinical parameters of the children did not predict the usefulness of FDG PET scans.

Conclusion

This is the first larger study demonstrating that FDG PET and PET/CT may be valuable diagnostic tools for the evaluation of children with FUO and unexplained signs of inflammation. Depicting inflammation in the whole body, while not being traumatic, it is attractive for use especially in children. The combination of PET with CT seems to be superior, since the site of inflammation can be localized more accurately.
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Metadaten
Titel
Diagnostic value of [18F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation
verfasst von
Niklas Jasper
Jan Däbritz
Michael Frosch
Markus Loeffler
Matthias Weckesser
Dirk Foell
Publikationsdatum
01.01.2010
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2010
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-009-1185-y