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Erschienen in:
21.03.2019 | Magnetic Resonance
Diagnostic value of MRI-PDFF for hepatic steatosis in patients with non-alcoholic fatty liver disease: a meta-analysis
Erschienen in: European Radiology | Ausgabe 7/2019
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Objective
To systematically review studies about the diagnostic accuracy of magnetic resonance imaging proton density fat fraction (MRI-PDFF) in the classification of hepatic steatosis grade in patients with non-alcoholic fatty liver disease (NAFLD).
Methods
Areas under the summary receiver operating characteristic curves (AUROC), sensitivity, specificity, overall diagnostic odds ratio (DOR), diagnostic score, positive likelihood ratio (+LR), and negative likelihood ratio (−LR) for MRI-PDFF in classification of steatosis grades 0 vs. 1–3, 0–1 vs. 2–3, and 0–2 vs. 3 were compared and analyzed.
Results
A total of 6 studies were included in this meta-analysis (n = 635). The summary AUROC values of MRI-PDFF for classifying steatosis grades 0 vs. 1–3, 0–1 vs. 2–3, and 0–2 vs. 3 were 0.98, 0.91, and 0.90, respectively. Pooled sensitivity and specificity of MRI-PDFF for classifying steatosis grades 0 vs. 1–3, 0–1 vs. 2–3, and 0–2 vs. 3 were 0.93 and 0.94, 0.74 and 0.90, and 0.74 and 0.87, respectively. Summary +LR and −LR of MRI-PDFF for classifying steatosis grades 0 vs. 1–3, 0–1 vs. 2–3, and 0–2 vs. 3 were 16.21 (95%CI, 4.72–55.67) and 0.08 (95%CI, 0.04–0.15), 7.19 (95%CI, 5.04–10.26) and 0.29 (95%CI, 0.22–0.38), and 5.89 (95%CI, 4.27–8.13) and 0.29 (95%CI, 0.21–0.41), respectively.
Conclusions
Our meta-analysis suggests that MRI-PDFF has excellent diagnostic value for assessment of hepatic fat content and classification of histologic steatosis in patients with NAFLD.
Key Points
• MRI-PDFF has significant diagnostic value for hepatic steatosis in patients with NAFLD.
• MRI-PDFF may be used to classify grade of hepatic steatosis with high sensitivity and specificity.