Background
Methods
Patient samples
Sample collection
Reagents and kits
Measurement of CTSB and CTSD
Statistical analysis
Results
Variables | Number (%) |
---|---|
Median Age (min–max) | 45 (16–77) |
Sex | |
Men | 52 (65) |
Women | 28 (35) |
Stage | |
II | 22 (27.5) |
III | 25 (31.25) |
IV | 33 (41.25) |
Pathology | |
Differentiated | 10 (12.5) |
Undifferentiated | 70 (87.5) |
Treatment | |
Yes | 68 (85) |
No | 12 (15) |
Relapse | |
None | 56 (70) |
Distant | 12 (15) |
Locoregional | 6 (7.5) |
Distant and Locoregional | 6 (7.5) |
Patients (n = 80) | Controls (n =40) | p value | |||
---|---|---|---|---|---|
Mean (±SD) | Median (min–max) | Mean (±SD) | Median (min–max) | ||
CTSB (mg/L) | 12.5 ± 3.5 | 12.4 (4.4–25.6) | 2.5 ± 1.4 | 2.1 (0.6–5.0) | 0.001 |
CTSD (mg/L) | 15.7 ± 8.7 | 14.7 (2–42.3) | 2.7 ± 0.8 | 2.8 (1.3–3.7) | 0.001 |
Variables | Number | CTSB (mg/L) | P value | CTSD (mg/L) | p value |
---|---|---|---|---|---|
Median (min–max) | Median (min–max) | ||||
Sex | |||||
Men | 52 | 12.4 (4.4–25.6) | 0.823 | 16.6 (2–42.3) | 0.153 |
Women | 28 | 12.0 (8.0–19.0) | 2.7 (4.6–29.1) | ||
Age, years | |||||
≤ 45 | 42 | 11.9 (4.4–25.6) | 0.855 | 15.3 (3.8–42.3) | 0.086 |
> 45 | 38 | 12.5 (7.8–19.0) | 14.4 (2–28.7) | ||
Smoking | |||||
Yes | 55 | 12.4 (6.5–25.6) | 0.583 | 14.7 (3.8–42.3) | 0.519 |
No | 25 | 12.5 (4.4–19.0) | 15.5 (2–29.6) | ||
Alcohol intake | |||||
Yes | 57 | 12.5 (5.0–25.6) | 0.675 | 14.4 (4.2–42.3) | 0.985 |
No | 23 | 12.4 (4.4–17.5) | 15.3 (2–33.4) | ||
TNM grade | |||||
I + II | 22 | 9.2 (4.4–17.3) | 0.0001 | 8.7 (2.0–24.7) | 0.002 |
III + IV | 58 | 13.1 (8.9–25.6) | 15.7 (2.8–42.60) | ||
EBV/VCA-IgA | |||||
≤ 1:160 | 44 | 11.9 (6.5–25.6) | 0.693 | 14.9 (4.2–33.4) | 0.441 |
≥ 1:320 | 36 | 12.6 (4.4–19.0) | 12.6 (2.0–42.6) |
Variables | Number | Median PFS | Univariate analysis | Multivariate analysis | |
---|---|---|---|---|---|
(months) | p value | p value | RR | ||
CTSB | |||||
> 12.4 mg/l | 42 | 37.0 | 0.699 | 0.878 | 0.938 |
≤ 12.4 mg/l | 38 | 37.8 | |||
CTSD | |||||
> 14.7 mg/l | 39 | 35.9 | 0.216 | 0.341 | 1.524 |
≤ 14.7 mg/l | 41 | 38.6 | |||
Sex | |||||
Men | 54 | 37.2 | 0.902 | 0.566 | 1.286 |
Women | 26 | 35.8 | |||
Age | |||||
≤ 45 years | 40 | 37.3 | 0.699 | 0.779 | 0.892 |
> 45 years | 40 | 37.5 | |||
TNM stage | |||||
I + II | 20 | 39.1 | 0.454 | 0.556 | 1.376 |
III + IV | 60 | 36.4 | |||
VCA-IgA | |||||
≤ 1:160 | 45 | 37.5 | 0.735 | 0.769 | 1.265 |
≥ 1:320 | 35 | 36.8 | |||
Smoking | |||||
Yes | 55 | 36.6 | 0.913 | 0.991 | 0.995 |
No | 25 | 37.9 |