Skip to main content
Erschienen in: Gastro-News 5/2019

13.09.2019 | Morbus Crohn | zertifizierte fortbildung

Komplikationen chronisch entzündlicher Darmerkrankungen

Perianale Fisteln bei Morbus Crohn

verfasst von: Prof. Dr. med. Max Reinshagen

Erschienen in: Gastro-News | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Perianale Fisteln sind eine häufige Komplikation des Morbus Crohn. Da es derzeit keine Heilung für den Morbus Crohn gibt, besteht die Behandlung in der Gabe antientzündlicher Medikamente zur Vermeidung neuer Krankheitsschübe, um eine weitere Ausbreitung der Fistelgänge zu vermeiden. Bei vielen Patienten werden chirurgische Eingriffe erforderlich, die bei komplexen Fisteln mit diversen Abzweigungen aber nicht immer zum Ziel führen.
Literatur
1.
Zurück zum Zitat Jiang H, Shen J, Ran Z Epithelial-mesenchymal transition in Crohn's disease. Mucosal Immunol 2018;11:294–303CrossRef Jiang H, Shen J, Ran Z Epithelial-mesenchymal transition in Crohn's disease. Mucosal Immunol 2018;11:294–303CrossRef
2.
Zurück zum Zitat Park SH, Aniwan S, Scott Harmsen W, Tremaine WJ, Lightner AL, Faubion WA, Loftus EV. Prevalence of Fistulizing Crohn's Disease in the United States: Estimate From a Systematic Literature Review Attempt and Population-Based Database Analysis. Schwartz DA et al. Inflamm Bowel Dis 2019;25:1054–1060CrossRef Park SH, Aniwan S, Scott Harmsen W, Tremaine WJ, Lightner AL, Faubion WA, Loftus EV. Prevalence of Fistulizing Crohn's Disease in the United States: Estimate From a Systematic Literature Review Attempt and Population-Based Database Analysis. Schwartz DA et al. Inflamm Bowel Dis 2019;25:1054–1060CrossRef
3.
Zurück zum Zitat Göttgens KW, Jeuring SF, Sturkenboom R, Romberg-Camps MJ, Oostenbrug LE, Jonkers DM, Stassen LP, Masclee AA, Pierik MJ, Breukink SO. Time trends in the epidemiology and outcome of perianal fistulizing Crohn's disease in a population-based cohort. Eur J Gastroenterol Hepatol 2017;29:595–601CrossRef Göttgens KW, Jeuring SF, Sturkenboom R, Romberg-Camps MJ, Oostenbrug LE, Jonkers DM, Stassen LP, Masclee AA, Pierik MJ, Breukink SO. Time trends in the epidemiology and outcome of perianal fistulizing Crohn's disease in a population-based cohort. Eur J Gastroenterol Hepatol 2017;29:595–601CrossRef
4.
Zurück zum Zitat Zhao M, Lo BZS, Vester-Andersen MK, Vind I, Bendtsen F, Burisch J. A 10-Year Follow-up Study of the Natural History of Perianal Crohn's Disease in a Danish Population-Based Inception Cohort. Inflamm Bowel Dis 2019;25:1227–1236CrossRef Zhao M, Lo BZS, Vester-Andersen MK, Vind I, Bendtsen F, Burisch J. A 10-Year Follow-up Study of the Natural History of Perianal Crohn's Disease in a Danish Population-Based Inception Cohort. Inflamm Bowel Dis 2019;25:1227–1236CrossRef
5.
Zurück zum Zitat Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, van Deventer SJ. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004;350:876–85CrossRef Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, van Deventer SJ. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004;350:876–85CrossRef
6.
Zurück zum Zitat Colombel JF, Schwartz DA, Sandborn WJ, Kamm MA, D'Haens G, Rutgeerts P, Enns R, Panaccione R, Schreiber S, Li J, Kent JD, Lomax KG, Pollack PF. Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut 2009;58:940–948CrossRef Colombel JF, Schwartz DA, Sandborn WJ, Kamm MA, D'Haens G, Rutgeerts P, Enns R, Panaccione R, Schreiber S, Li J, Kent JD, Lomax KG, Pollack PF. Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut 2009;58:940–948CrossRef
7.
Zurück zum Zitat Lee MJ, Parker CE, Taylor SR, Guizzetti L, Feagan BG, Lobo AJ, Jairath V. Efficacy of Medical Therapies for Fistulizing Crohn's Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018;16:1879–1892CrossRef Lee MJ, Parker CE, Taylor SR, Guizzetti L, Feagan BG, Lobo AJ, Jairath V. Efficacy of Medical Therapies for Fistulizing Crohn's Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018;16:1879–1892CrossRef
8.
Zurück zum Zitat Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016;388:1281–90CrossRef Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016;388:1281–90CrossRef
9.
Zurück zum Zitat Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology 2018 Apr;154(5):1334–1342.e4. doi: https://doi.org/10.1053/j.gastro.2017.12.020. Epub 2017 Dec 24.CrossRef Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology 2018 Apr;154(5):1334–1342.e4. doi: https://​doi.​org/​10.​1053/​j.​gastro.​2017.​12.​020. Epub 2017 Dec 24.CrossRef
10.
Zurück zum Zitat Diez MC, Tagarro I, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology 2018;154:1334–1342CrossRef Diez MC, Tagarro I, Leselbaum A, Danese S; ADMIRE CD Study Group Collaborators. Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease. Gastroenterology 2018;154:1334–1342CrossRef
11.
Zurück zum Zitat Legué C, Brochard C, Bessi G, Wallenhorst T, Dewitte M, Siproudhis L, Bouguen G. Outcomes of Perianal Fistulising Crohn's Disease Following Anti-TNFa Treatment Discontinuation. Inflamm Bowel Dis 2018;24:1107–1113CrossRef Legué C, Brochard C, Bessi G, Wallenhorst T, Dewitte M, Siproudhis L, Bouguen G. Outcomes of Perianal Fistulising Crohn's Disease Following Anti-TNFa Treatment Discontinuation. Inflamm Bowel Dis 2018;24:1107–1113CrossRef
12.
Zurück zum Zitat Burke JP. Role of Fecal Diversion in Complex Crohn's Disease. Clin Colon Rectal Surg 2019 Jul;32(4):273–279CrossRef Burke JP. Role of Fecal Diversion in Complex Crohn's Disease. Clin Colon Rectal Surg 2019 Jul;32(4):273–279CrossRef
13.
Zurück zum Zitat Dozois EJ, Lightner AL, Mathis KL, Chua HK, Kelley SR, Fletcher JG, Dietz AB, Friton JJ, Butler GW, Faubion WA. Results of a Phase I Trial Using an Adipose-Derived Mesenchymal Stem Cell-Coated Fistula Plug for the Treatment of Transsphincteric Cryptoglandular Fistulas. Dis Colon Rectum 2019; 62:615–622CrossRef Dozois EJ, Lightner AL, Mathis KL, Chua HK, Kelley SR, Fletcher JG, Dietz AB, Friton JJ, Butler GW, Faubion WA. Results of a Phase I Trial Using an Adipose-Derived Mesenchymal Stem Cell-Coated Fistula Plug for the Treatment of Transsphincteric Cryptoglandular Fistulas. Dis Colon Rectum 2019; 62:615–622CrossRef
14.
Zurück zum Zitat Serrero M, Grimaud F, Philandrianos C, Visée C, Sabatier F, Grimaud JC. Long-term Safety and Efficacy of Local Microinjection Combining Autologous Microfat and Adipose-Derived Stromal Vascular Fraction for the Treatment of Refractory Perianal Fistula in Crohn's Disease. Gastroenterology 2019;156, 2335–2337CrossRef Serrero M, Grimaud F, Philandrianos C, Visée C, Sabatier F, Grimaud JC. Long-term Safety and Efficacy of Local Microinjection Combining Autologous Microfat and Adipose-Derived Stromal Vascular Fraction for the Treatment of Refractory Perianal Fistula in Crohn's Disease. Gastroenterology 2019;156, 2335–2337CrossRef
15.
Zurück zum Zitat Dige A, Hougaard HT, Agnholt J, Pedersen BG, Tencerova M, Kassem M, Krogh K, Lundby L Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease.. Gastroenterology 2019;156, 2208–2216CrossRef Dige A, Hougaard HT, Agnholt J, Pedersen BG, Tencerova M, Kassem M, Krogh K, Lundby L Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease.. Gastroenterology 2019;156, 2208–2216CrossRef
Metadaten
Titel
Komplikationen chronisch entzündlicher Darmerkrankungen
Perianale Fisteln bei Morbus Crohn
verfasst von
Prof. Dr. med. Max Reinshagen
Publikationsdatum
13.09.2019
Verlag
Springer Medizin
Schlagwort
Morbus Crohn
Erschienen in
Gastro-News / Ausgabe 5/2019
Print ISSN: 1869-1005
Elektronische ISSN: 2520-8667
DOI
https://doi.org/10.1007/s15036-019-0487-6

Weitere Artikel der Ausgabe 5/2019

Gastro-News 5/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.