Erschienen in:
15.07.2019 | EDITORIAL
Diastolic assessment by CZT-SPECT: Could it be the next best thing for the detection of subclinical chemotherapy-induced cardiotoxicity?
verfasst von:
Efstathia Andrikopoulou, MD
Erschienen in:
Journal of Nuclear Cardiology
|
Ausgabe 4/2020
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Excerpt
Advancements in modern medicine have resulted in a continuously growing population of survivors of adult and pediatric malignancies.
1 This is paralleled by an increased recognition of the cardiac damage induced by chemotherapy and radiation therapy, collectively termed “cancer therapeutics-related cardiac dysfunction” (CTRCD).
2 It is now well established that, left untreated, CTRCD may result in numerous adverse cardiovascular effects, namely, left ventricular (LV) dysfunction, congestive heart failure, and ultimately increased cardiovascular mortality.
3 Myocardial recovery and improved survival rely on early diagnosis of CTRCD and prompt initiation of medical therapy.
3 Non-invasive cardiac imaging has been traditionally used to detect CTRCD, namely, 2-D echocardiography (Echo), cardiac magnetic resonance (CMR), and radionuclide imaging (multi-gated acquisition, MUGA, and single-photon emission computed tomography, SPECT).
2,
4,
5 These modalities are mostly geared towards quantifying the left ventricular ejection fraction (LVEF), as an index of the status of LV systolic function.
4 It is becoming increasingly evident though, that reduction in the LVEF may signify advanced and possibly irreversible cardiac damage. This emphasizes the need for detection of markers of subclinical cardiotoxicity. …