Skip to main content
Erschienen in: Arthroskopie 3/2005

01.08.2005 | Leitthema

Die Rolle der Zytokine bei Knorpeldefekten und in der Knorpeltherapie

Interleukin-1 und TNF-α: Schlüsselfaktoren der Knorpeldestruktion

verfasst von: C. Moser, A. Baltzer, J. Reinecke, Prof. Dr. P. Wehling

Erschienen in: Arthroskopie | Ausgabe 3/2005

Einloggen, um Zugang zu erhalten

Zusammenfassung

Zytokine spielen eine Schlüsselrolle in der Pathogenese degenerativer aber auch inflammatorischer Gelenkerkrankungen wie der Osteoarthrose (OA) und rheumatoiden Arthritis (RA). Eine besondere Rolle wird dabei dem Interleukin-1 und dem TNF-α zugeschrieben. Bestimmte Zytokine, welche die Wirkung der katabolen Zytokine inhibieren, besitzen großes therapeutisches Potenzial und werden durch zahlreiche klinische Studien derzeit näher untersucht. Stand der Wissenschaft ist, dass proinflammatorische Zytokine den Knorpelabbau stimulieren und deren Blockade den Knorpel schützen kann.
Literatur
1.
Zurück zum Zitat Arend WP et al. (1998) Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 16:27–55 CrossRefPubMed Arend WP et al. (1998) Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol 16:27–55 CrossRefPubMed
2.
Zurück zum Zitat Baltzer AWA et al. (2003) Intraartikuläre Therapie der Gonarthrose mit autologen Interleukin-1-Rezeptorantagonisten (IL-1Ra). Dtsch Z Sportmed 54(6):209–211 Baltzer AWA et al. (2003) Intraartikuläre Therapie der Gonarthrose mit autologen Interleukin-1-Rezeptorantagonisten (IL-1Ra). Dtsch Z Sportmed 54(6):209–211
3.
Zurück zum Zitat Berg L et al. (2001) Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNFalpha receptors. Ann Rheum Dis 60(2):133–139 CrossRefPubMed Berg L et al. (2001) Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNFalpha receptors. Ann Rheum Dis 60(2):133–139 CrossRefPubMed
4.
Zurück zum Zitat Caron JP et al. (1996) Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids. Am J Vet Res 57(11):1631–1634 PubMed Caron JP et al. (1996) Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids. Am J Vet Res 57(11):1631–1634 PubMed
5.
Zurück zum Zitat Di Battista JA et al. (2001) Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts. Clin Exp Rheumatol 19(1) [suppl 22]:S3–5 Di Battista JA et al. (2001) Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts. Clin Exp Rheumatol 19(1) [suppl 22]:S3–5
6.
Zurück zum Zitat Evans CH et al. (2005) Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A, in press Evans CH et al. (2005) Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A, in press
7.
Zurück zum Zitat Farahat MN et al. (1993) Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 52(12):870–875 PubMed Farahat MN et al. (1993) Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 52(12):870–875 PubMed
8.
Zurück zum Zitat Fernandes JC, Martel-Pelletier J, Pelletier JP (2002) The role of cytokines in osteoarthritis pathophysiology. Biorheology 39(1–2):237–246 Fernandes JC, Martel-Pelletier J, Pelletier JP (2002) The role of cytokines in osteoarthritis pathophysiology. Biorheology 39(1–2):237–246
9.
Zurück zum Zitat Frisbie DD et al. (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 9(1):12–20 CrossRefPubMed Frisbie DD et al. (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 9(1):12–20 CrossRefPubMed
10.
Zurück zum Zitat Gabay C, Arend WP (1998) Treatment of rheumatoid arthritis with IL-1 inhibitors. Semin Immunopathol 20(1–2):229–246 Gabay C, Arend WP (1998) Treatment of rheumatoid arthritis with IL-1 inhibitors. Semin Immunopathol 20(1–2):229–246
11.
Zurück zum Zitat Goldring MB (2000) Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2(6):459–465 PubMed Goldring MB (2000) Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2(6):459–465 PubMed
12.
Zurück zum Zitat Goldring SR, Goldring MB (2004) The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 427 [suppl]:S27–36 Goldring SR, Goldring MB (2004) The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 427 [suppl]:S27–36
13.
Zurück zum Zitat Goupille P, Giraubeau B, Conrozier T et al. (2003) Safety and efficacy of patients with painful osteoarthritis of the knee: a multicenter double blind study. Arthritis Rheum 48:S696–697 Goupille P, Giraubeau B, Conrozier T et al. (2003) Safety and efficacy of patients with painful osteoarthritis of the knee: a multicenter double blind study. Arthritis Rheum 48:S696–697
14.
Zurück zum Zitat Henderson B, Pettipher ER (1989) Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo. Clin Exp Immunol 75(2):306–310 PubMed Henderson B, Pettipher ER (1989) Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo. Clin Exp Immunol 75(2):306–310 PubMed
15.
Zurück zum Zitat Joosten LA et al. (1999) IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol 163(9):5049–5055 PubMed Joosten LA et al. (1999) IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol 163(9):5049–5055 PubMed
16.
Zurück zum Zitat Lubberts E, van den Berg WB (2001) Potential of modulatory cytokines in the rheumatoid arthritis process. Drug News Perspect 14(9):517–522 CrossRefPubMed Lubberts E, van den Berg WB (2001) Potential of modulatory cytokines in the rheumatoid arthritis process. Drug News Perspect 14(9):517–522 CrossRefPubMed
17.
Zurück zum Zitat Meijer H et al. (2003) The production of anti-inflammatory cytokines in whole blood by physico-chemical induction. Inflamm Res 52(10):404–407 CrossRefPubMed Meijer H et al. (2003) The production of anti-inflammatory cytokines in whole blood by physico-chemical induction. Inflamm Res 52(10):404–407 CrossRefPubMed
18.
Zurück zum Zitat Melchiorri C et al. (1998) Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 41(12):2165–2174 CrossRefPubMed Melchiorri C et al. (1998) Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. Arthritis Rheum 41(12):2165–2174 CrossRefPubMed
19.
Zurück zum Zitat Meyer FA, Yaron I, Yaron M (1990) Synergistic additive and antagonistic effects of interleukin-1 beta tumor necrosis factor alpha and gamma-interferon on prostaglandin E hyaluronic acid and collagenase production by cultured synovial fibroblasts. Arthritis Rheum 33(10):1518–1525 PubMed Meyer FA, Yaron I, Yaron M (1990) Synergistic additive and antagonistic effects of interleukin-1 beta tumor necrosis factor alpha and gamma-interferon on prostaglandin E hyaluronic acid and collagenase production by cultured synovial fibroblasts. Arthritis Rheum 33(10):1518–1525 PubMed
20.
Zurück zum Zitat Millward-Sadler SJ et al. (2000) Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum 43(9):2091–2099 CrossRefPubMed Millward-Sadler SJ et al. (2000) Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum 43(9):2091–2099 CrossRefPubMed
21.
Zurück zum Zitat Moos V et al. (1999) Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 26(4):870–879 PubMed Moos V et al. (1999) Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 26(4):870–879 PubMed
22.
Zurück zum Zitat Moos V et al. (2001) Regulation of expression of cytokines and growth factors in osteoarthritic cartilage explants. Clin Rheumatol 20(5):353–358 CrossRefPubMed Moos V et al. (2001) Regulation of expression of cytokines and growth factors in osteoarthritic cartilage explants. Clin Rheumatol 20(5):353–358 CrossRefPubMed
23.
Zurück zum Zitat Page Thomas DP et al. (1991) In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1. Ann Rheum Dis 50(2):75–80 PubMed Page Thomas DP et al. (1991) In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1. Ann Rheum Dis 50(2):75–80 PubMed
23a.
Zurück zum Zitat Pelletier JP et al. (1997) In vivo suppression of early osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 40:1012–1019 PubMed Pelletier JP et al. (1997) In vivo suppression of early osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 40:1012–1019 PubMed
24.
Zurück zum Zitat Poole AR et al. (2001) Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res 391 [suppl]:S26–33 Poole AR et al. (2001) Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res 391 [suppl]:S26–33
25.
26.
Zurück zum Zitat Smith MD et al. (1997) Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 24(2):365–371 PubMed Smith MD et al. (1997) Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 24(2):365–371 PubMed
27.
Zurück zum Zitat Tetlow LC, Adlam DJ, Woolley DE (2001) Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 44(3):585–594 CrossRefPubMed Tetlow LC, Adlam DJ, Woolley DE (2001) Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 44(3):585–594 CrossRefPubMed
28.
Zurück zum Zitat Towle CA et al. (1997) Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthr Cartil 5(5):293–300 PubMed Towle CA et al. (1997) Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthr Cartil 5(5):293–300 PubMed
29.
Zurück zum Zitat Van Beuningen HM, Arntz OJ, van den Berg WB (1991) In vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice. Arthritis Rheum 34(5):606–615 PubMed Van Beuningen HM, Arntz OJ, van den Berg WB (1991) In vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice. Arthritis Rheum 34(5):606–615 PubMed
30.
Zurück zum Zitat Van den Berg WB et al. (1991) In vivo evidence for a key< role of IL-1 in cartilage destruction in experimental arthritis. Agents Actions 32 [suppl]:159–163 Van den Berg WB et al. (1991) In vivo evidence for a key< role of IL-1 in cartilage destruction in experimental arthritis. Agents Actions 32 [suppl]:159–163
31.
Zurück zum Zitat Westacott CI et al. (1990) Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 49(9):676–681 PubMed Westacott CI et al. (1990) Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 49(9):676–681 PubMed
Metadaten
Titel
Die Rolle der Zytokine bei Knorpeldefekten und in der Knorpeltherapie
Interleukin-1 und TNF-α: Schlüsselfaktoren der Knorpeldestruktion
verfasst von
C. Moser
A. Baltzer
J. Reinecke
Prof. Dr. P. Wehling
Publikationsdatum
01.08.2005
Verlag
Springer-Verlag
Erschienen in
Arthroskopie / Ausgabe 3/2005
Print ISSN: 0933-7946
Elektronische ISSN: 1434-3924
DOI
https://doi.org/10.1007/s00142-005-0312-4

Weitere Artikel der Ausgabe 3/2005

Arthroskopie 3/2005 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, DICOM-Daten, Videos und Abbildungen. » Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.