nach oben

Erschienen in:

22.05.2019 | Original Contribution

Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity

verfasst von: B. Scazzocchio, R. Varì, A. Silenzi, S. Giammarioli, A. Masotti, A. Baldassarre, C. Santangelo, M. D’Archivio, C. Giovannini, M. Del Cornò, L. Conti, S. Gessani, R. Masella

Erschienen in: European Journal of Nutrition | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Aim of this study was to identify a possible relationship among dietary fatty acids (FA) intake, FA adipose tissue (AT) profile and cancer condition in lean vs obese subjects affected or not by colorectal cancer (CRC). Actually, inadequate dietary habits together with physical inactivity are primary determinants of obesity and cancer risk. Changes in lipid metabolism play a crucial role in different types of cancer and key enzymes involved in lipid-metabolic pathways, such as stearoyl-coA-desaturase 1 (SCD-1), are differentially expressed in normal and cancer tissues.

Methods

Food frequency questionnaires (FFQ) were analyzed by Winfood software. FA were assessed by gas–liquid chromatography in visceral AT samples. Estimated desaturase activities were calculated as precursor FA/product FA ratio. Desaturase gene expressions were evaluated by RT-qPCR.

Results

Lean and obese CRC subjects showed inadequate dietary habits. In particular, lean CRC subjects showed increase in the intake of saturated FA, specifically palmitic (p = 0.0042) and stearic acid (p = 0.0091), and a corresponding reduction of monounsaturated FA consumption, in particular oleic acid (p = 0.002) with respect to lean without CRC. Estimated SCD-1 activity in AT was increased in all the groups vs lean without CRC (pANOVA = 0.029).

Conclusions

Unhealthy eating habits, characterizing obese and CRC subjects, may influence the visceral AT profile and contribute to the alteration of the metabolic pathways. The quality of the diet, other than the quantity, can have a main role in the establishment of inflammatory microenvironment and in metabolic changes favouring CRC.

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F (2017) Global patterns and trends in colorectal cancer incidence and mortality. Gut 66(4):683–691. https://doi.org/10.1136/gutjnl-2015-310912 CrossRefPubMed

World Cancer Research Fund/American Institute for Cancer Research (2017) Continuous update project report: diet, nutrition, physical activity and colorectal cancer. https://www.wcrf.org/

Bardou M, Barkun AN, Martel M (2013) Obesity and colorectal cancer. Gut 62(6):933–947. https://doi.org/10.1136/gutjnl-2013-304701 CrossRefPubMed

Howard BV, Van Horn L, Hsia J, Manson JE, Stefanick ML, Wassertheil-Smoller S, Kuller LH, LaCroix AZ, Langer RD, Lasser NL, Lewis CE, Limacher MC, Margolis KL, Mysiw WJ, Ockene JK, Parker LM, Perri MG, Phillips L, Prentice RL, Robbins J, Rossouw JE, Sarto GE, Schatz IJ, Snetselaar LG, Stevens VJ, Tinker LF, Trevisan M, Vitolins MZ, Anderson GL, Assaf AR, Bassford T, Beresford SA, Black HR, Brunner RL, Brzyski RG, Caan B, Chlebowski RT, Gass M, Granek I, Greenland P, Hays J, Heber D, Heiss G, Hendrix SL, Hubbell FA, Johnson KC, Kotchen JM (2006) Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295(6):655–666. https://doi.org/10.1001/jama.295.6.655 CrossRefPubMed

Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC (1997) Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 337(21):1491–1499. https://doi.org/10.1056/NEJM199711203372102 CrossRefPubMed

Agnoli C, Grioni S, Sieri S, Palli D, Masala G, Sacerdote C, Vineis P, Tumino R, Giurdanella MC, Pala V, Berrino F, Mattiello A, Panico S, Krogh V (2013) Italian Mediterranean Index and risk of colorectal cancer in the Italian section of the EPIC cohort. Int J Cancer Journal international du cancer 132(6):1404–1411. https://doi.org/10.1002/ijc.27740 CrossRefPubMed

Bennacer AF, Haffaf E, Kacimi G, Oudjit B, Koceir EA (2017) Association of polyunsaturated/saturated fatty acids to metabolic syndrome cardiovascular risk factors and lipoprotein (a) in hypertensive type 2 diabetic patients. Ann Biol Clin 75(3):293–304. https://doi.org/10.1684/abc.2017.1244 CrossRef

Yanai H, Masui Y, Katsuyama H, Adachi H, Kawaguchi A, Hakoshima M, Waragai Y, Harigae T, Sako A (2018) An improvement of cardiovascular risk factors by omega-3 polyunsaturated fatty acids. J Clin Med Res 10(4):281–289. https://doi.org/10.14740/jocmr3362w CrossRefPubMedPubMedCentral

Jones R, Adel-Alvarez LA, Alvarez OR, Broaddus R, Das S (2003) Arachidonic acid and colorectal carcinogenesis. Mol Cell Biochem 253(1–2):141–149PubMed

10.

Boudreau MD, Sohn KH, Rhee SH, Lee SW, Hunt JD, Hwang DH (2001) Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. Can Res 61(4):1386–1391

11.

May-Wilson S, Sud A, Law PJ, Palin K, Tuupanen S, Gylfe A, Hanninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepisto A, Bohm J, Mecklin JP, Al-Tassan NA, Palles C, Farrington SM, Timofeeva MN, Meyer BF, Wakil SM, Campbell H, Smith CG, Idziaszczyk S, Maughan TS, Fisher D, Kerr R, Kerr D, Passarelli MN, Figueiredo JC, Buchanan DD, Win AK, Hopper JL, Jenkins MA, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Aaltonen LA, Cheadle JP, Tomlinson IP, Dunlop MG, Houlston RS (2017) Pro-inflammatory fatty acid profile and colorectal cancer risk: a Mendelian randomisation analysis. Eur J Cancer 84:228–238. https://doi.org/10.1016/j.ejca.2017.07.034 CrossRefPubMedPubMedCentral

12.

Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM (2009) Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8:41. https://doi.org/10.1186/1476-4598-8-41 CrossRefPubMedPubMedCentral

13.

Santos CR, Schulze A (2012) Lipid metabolism in cancer. FEBS J 279(15):2610–2623. https://doi.org/10.1111/j.1742-4658.2012.08644.x CrossRefPubMed

14.

Giuliani A, Ferrara F, Scimo M, Angelico F, Olivieri L, Basso L (2014) Adipose tissue fatty acid composition and colon cancer: a case–control study. Eur J Nutr 53(4):1029–1037. https://doi.org/10.1007/s00394-013-0605-8 CrossRefPubMed

15.

Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA (2011) Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res 9(11):1551–1561. https://doi.org/10.1158/1541-7786.MCR-11-0126 CrossRefPubMed

16.

Cottet V, Vaysse C, Scherrer ML, Ortega-Deballon P, Lakkis Z, Delhorme JB, Deguelte-Lardiere S, Combe N, Bonithon-Kopp C (2015) Fatty acid composition of adipose tissue and colorectal cancer: a case-control study. Am J Clin Nutr 101(1):192–201. https://doi.org/10.3945/ajcn.114.088948 CrossRefPubMed

17.

Rostami H, Samadi M, Yuzbashian E, Zarkesh M, Asghari G, Hedayati M, Daneshafrooz A, Mirmiran P, Khalaj A (2017) Habitual dietary intake of fatty acids are associated with leptin gene expression in subcutaneous and visceral adipose tissue of patients without diabetes. Prostaglandins Leukot Essent Fatty Acids 126:49–54. https://doi.org/10.1016/j.plefa.2017.09.010 CrossRefPubMed

18.

van Staveren WA, Deurenberg P, Katan MB, Burema J, de Groot LC, Hoffmans MD (1986) Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. Am J Epidemiol 123(3):455–463CrossRefPubMed

19.

Hunter DJ, Rimm EB, Sacks FM, Stampfer MJ, Colditz GA, Litin LB, Willett WC (1992) Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men. Am J Epidemiol 135(4):418–427CrossRefPubMed

20.

Garland M, Sacks FM, Colditz GA, Rimm EB, Sampson LA, Willett WC, Hunter DJ (1998) The relation between dietary intake and adipose tissue composition of selected fatty acids in US women. Am J Clin Nutr 67(1):25–30. https://doi.org/10.1093/ajcn/67.1.25 CrossRefPubMed

21.

Jeppesen C, Eika Jorgensen M, Bjerregaard P (2012) Assessment of consumption of marine food in Greenland by a food frequency questionnaire and biomarkers. Int J Circumpolar Health 71(1):18361. https://doi.org/10.3402/ijch.v71i0.18361 CrossRefPubMed

22.

D’Archivio M, Scazzocchio B, Giammarioli S, Fiani ML, Vari R, Santangelo C, Veneziani A, Iacovelli A, Giovannini C, Gessani S, Masella R (2013) omega3-PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients. PLoS One 8(10):e77432. https://doi.org/10.1371/journal.pone.0077432 CrossRefPubMedPubMedCentral

23.

Turconi G, Bazzano R, Roggi C, Cena H (2010) Reliability and relative validity of a quantitative food-frequency questionnaire for use among adults in Italian population. Int J Food Sci Nutr 61(8):846–862. https://doi.org/10.3109/09637486.2010.495329 CrossRefPubMed

24.

Turconi G, Guarcello M, Berzolari FG, Carolei A, Bazzano R, Roggi C (2005) An evaluation of a colour food photography atlas as a tool for quantifying food portion size in epidemiological dietary surveys. Eur J Clin Nutr 59(8):923–931. https://doi.org/10.1038/sj.ejcn.1602162 CrossRefPubMed

25.

European Food Safety Authority (2014) Guidance on the EU Menu methodology. EFSA J 12(12):3944

26.

Panel on Dietetic Products, Nutrition and Allergies (2013) Scientific opinion on dietary reference values for energy. EFSA J 11(1):3005CrossRef

27.

Martinez-Gonzalez MA, Garcia-Arellano A, Toledo E, Salas-Salvado J, Buil-Cosiales P, Corella D, Covas MI, Schroder H, Aros F, Gomez-Gracia E, Fiol M, Ruiz-Gutierrez V, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pinto X, Munoz MA, Warnberg J, Ros E, Estruch R, Investigators PS (2012) A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial. PLoS One 7(8):e43134. https://doi.org/10.1371/journal.pone.0043134 CrossRefPubMedPubMedCentral

28.

Domingo JL, Nadal M (2017) Carcinogenicity of consumption of red meat and processed meat: a review of scientific news since the IARC decision. Food Chem Toxico 105:256–261. https://doi.org/10.1016/j.fct.2017.04.028 CrossRef

29.

Warensjo E, Rosell M, Hellenius ML, Vessby B, De Faire U, Riserus U (2009) Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids Health Dis 8:37. https://doi.org/10.1186/1476-511X-8-37 CrossRefPubMedPubMedCentral

30.

(SINU), S.I.d.N.U. IV Revisione dei Livelli di Assunzione di Riferimento di Nutrienti ed Energia per la Popolazione Italiana (Larn). Available online: http://www.sinu.it/html/pag/tabelle_larn_2014_rev.asp. Accessed 1 June 2018

31.

Vargas T, Moreno-Rubio J, Herranz J, Cejas P, Molina S, Gonzalez-Vallinas M, Mendiola M, Burgos E, Aguayo C, Custodio AB, Machado I, Ramos D, Gironella M, Espinosa-Salinas I, Ramos R, Martin-Hernandez R, Risueno A, De Las Rivas J, Reglero G, Yaya R, Fernandez-Martos C, Aparicio J, Maurel J, Feliu J, Ramirez de Molina A (2015) ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients. Oncotarget 6(9):7348–7363. https://doi.org/10.18632/oncotarget.3130 CrossRefPubMedPubMedCentral

32.

Donovan MG, Selmin OI, Doetschman TC, Romagnolo DF (2017) Mediterranean diet: prevention of colorectal cancer. Front Nutr 4:59. https://doi.org/10.3389/fnut.2017.00059 CrossRefPubMedPubMedCentral

33.

Dixon LB, Subar AF, Peters U, Weissfeld JL, Bresalier RS, Risch A, Schatzkin A, Hayes RB (2007) Adherence to the USDA Food Guide, DASH Eating Plan, and Mediterranean dietary pattern reduces risk of colorectal adenoma. J Nutr 137(11):2443–2450. https://doi.org/10.1093/jn/137.11.2443 CrossRefPubMed

34.

Jayasekara H, MacInnis RJ, Williamson EJ, Hodge AM, Clendenning M, Rosty C, Walters R, Room R, Southey MC, Jenkins MA, Milne RL, Hopper JL, Giles GG, Buchanan DD, English DR (2017) Lifetime alcohol intake is associated with an increased risk of KRAS + and BRAF-/KRAS- but not BRAF + colorectal cancer. Int J Cancer Journal international du cancer 140(7):1485–1493. https://doi.org/10.1002/ijc.30568 CrossRefPubMed

35.

Gay LJ, Mitrou PN, Keen J, Bowman R, Naguib A, Cooke J, Kuhnle GG, Burns PA, Luben R, Lentjes M, Khaw KT, Ball RY, Ibrahim AE, Arends MJ (2012) Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. J Pathol 228(3):405–415. https://doi.org/10.1002/path.4085 CrossRefPubMed

36.

Gay LJ, Arends MJ, Mitrou PN, Bowman R, Ibrahim AE, Happerfield L, Luben R, McTaggart A, Ball RY, Rodwell SA (2011) MLH1 promoter methylation, diet, and lifestyle factors in mismatch repair deficient colorectal cancer patients from EPIC-Norfolk. Nutr Cancer 63(7):1000–1010. https://doi.org/10.1080/01635581.2011.596987 CrossRefPubMed

37.

Mehra K, Berkowitz A, Sanft T (2017) Diet, physical activity, and body weight in cancer survivorship. Medical Clin N Am 101(6):1151–1165. https://doi.org/10.1016/j.mcna.2017.06.004 CrossRef

38.

McDaniel J, Askew W, Bennett D, Mihalopoulos J, Anantharaman S, Fjeldstad AS, Rule DC, Nanjee NM, Harris RA, Richardson RS (2013) Bison meat has a lower atherogenic risk than beef in healthy men. Nutr Res 33(4):293–302. https://doi.org/10.1016/j.nutres.2013.01.007 CrossRefPubMedPubMedCentral

39.

Torres N, Guevara-Cruz M, Velazquez-Villegas LA, Tovar AR (2015) Nutrition and atherosclerosis. Arch Med Res 46(5):408–426. https://doi.org/10.1016/j.arcmed.2015.05.010 CrossRefPubMed

40.

Sarbagili-Shabat C, Sigall-Boneh R, Levine A (2015) Nutritional therapy in inflammatory bowel disease. Curr Opin Gastroenterol 31(4):303–308. https://doi.org/10.1097/MOG.0000000000000178 CrossRefPubMed

41.

Zhu QC, Gao RY, Wu W, Guo BM, Peng JY, Qin HL (2014) Effect of a high-fat diet in development of colonic adenoma in an animal model. World J Gastroenterol 20(25):8119–8129. https://doi.org/10.3748/wjg.v20.i25.8119 CrossRefPubMedPubMedCentral

42.

Monteiro R, Azevedo I (2010) Chronic inflammation in obesity and the metabolic syndrome. Mediat inflamm. https://doi.org/10.1155/2010/289645

43.

Del Corno M, D’Archivio M, Conti L, Scazzocchio B, Vari R, Donninelli G, Varano B, Giammarioli S, De Meo S, Silecchia G, Pennestri F, Persiani R, Masella R, Gessani S (2016) Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells. Oncotarget 7(39):63093–63105. https://doi.org/10.18632/oncotarget.10998 CrossRefPubMedPubMedCentral

44.

Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47(5):348–380. https://doi.org/10.1016/j.plipres.2008.03.003 CrossRefPubMed

45.

Strawford A, Antelo F, Christiansen M, Hellerstein MK (2004) Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O. Am J Physiol Endocrinol Metab 286(4):E577–E588. https://doi.org/10.1152/ajpendo.00093.2003 CrossRefPubMed

46.

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. https://doi.org/10.1016/j.cell.2011.02.013 CrossRefPubMed

47.

Menendez JA, Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7(10):763–777. https://doi.org/10.1038/nrc2222 CrossRefPubMed

48.

Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G (2005) Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun 332(3):735–742. https://doi.org/10.1016/j.bbrc.2005.05.013 CrossRefPubMed

49.

Ntambi JM, Miyazaki M (2003) Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14(3):255–261. https://doi.org/10.1097/01.mol.0000073502.41685.c7 CrossRefPubMed

50.

Sjogren P, Sierra-Johnson J, Gertow K, Rosell M, Vessby B, de Faire U, Hamsten A, Hellenius ML, Fisher RM (2008) Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. Diabetologia 51(2):328–335. https://doi.org/10.1007/s00125-007-0876-9 CrossRefPubMed

51.

Donninelli G, Del Corno M, Pierdominici M, Scazzocchio B, Vari R, Varano B, Pacella I, Piconese S, Barnaba V, D’Archivio M, Masella R, Conti L, Gessani S (2017) Distinct blood and visceral adipose tissue regulatory T cell and innate lymphocyte profiles characterize obesity and colorectal cancer. Front Immunol 8:643. https://doi.org/10.3389/fimmu.2017.00643 CrossRefPubMedPubMedCentral

52.

D’Archivio M, Scazzocchio B, Vari R, Santangelo C, Giovannini C, Masella R (2018) Recent evidence on the role of dietary PUFAs in cancer development and prevention. Curr Med Chem 25(16):1818–1836. https://doi.org/10.2174/0929867325666171204160231 CrossRefPubMed

53.

Vaittinen M, Mannisto V, Kakela P, Agren J, Tiainen M, Schwab U, Pihlajamaki J (2017) Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity. Obesity 25(3):545–552. https://doi.org/10.1002/oby.21753 CrossRefPubMed

Titel: Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity
verfasst von: B. Scazzocchio
R. Varì
A. Silenzi
S. Giammarioli
A. Masotti
A. Baldassarre
C. Santangelo
M. D’Archivio
C. Giovannini
M. Del Cornò
L. Conti
S. Gessani
R. Masella
Publikationsdatum: 22.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02003-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2020

Effects of a formula with a probiotic Bifidobacterium lactis Supplement on the gut microbiota of low birth weight infants

Oxidative stress, DNA stability and evoked inflammatory signaling in young celiac patients consuming a gluten-free diet

Polyunsaturated fatty acids and risk of Alzheimer’s disease: a Mendelian randomization study

The bioavailability of iron picolinate is comparable to iron sulfate when fortified into a complementary fruit yogurt: a stable iron isotope study in young women

Altered gut microbiota ameliorates bone pathology in the mandible of obese–insulin-resistant rats

Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin