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29.03.2018 | Original Contribution

Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway inflammation

verfasst von: Victor F. Zevallos, Verena K. Raker, Joachim Maxeiner, Petra Scholtes, Kerstin Steinbrink, Detlef Schuppan

Erschienen in: European Journal of Nutrition | Ausgabe 4/2019

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Abstract

Background

Wheat amylase trypsin inhibitors (ATI) are dietary non-gluten proteins that activate the toll-like receptor 4 on myeloid cells, promoting intestinal inflammation.

Aim of the study

We investigated the effects of dietary ATI on experimental allergic airway inflammation.

Methods

Mice on a gluten and ATI-free diet (GAFD), sensitized with PBS or ovalbumin (OVA) and challenged with OVA, were compared to mice on a commercial standard chow, a gluten diet naturally containing ~ 0.75% of protein as ATI (G+AD), a gluten diet containing ~ 0.19% of protein as ATI (G−AD) and a GAFD with 1% of protein as ATI (AD). Airway hyperreactivity (AHR), inflammation in bronchoalveolar lavage (BAL) and pulmonary tissue sections were analyzed. Allergic sensitization was assessed ex vivo via proliferation of OVA-stimulated splenocytes.

Results

Mice on a GAFD sensitized with PBS did not develop AHR after local provocation with methacholine. Mice on a GAFD or on a G−AD and sensitized with OVA developed milder AHR compared to mice fed a G+AD or an AD. The increased AHR was paralleled by increased BAL eosinophils, IL-5 and IL-13 production, and an enhanced ex vivo splenocyte activation in the ATI-fed groups.

Conclusions

Dietary ATI enhance allergic airway inflammation in OVA-challenged mice, while an ATI-free or ATI-reduced diet has a protective effect on AHR. Nutritional wheat ATI, activators of intestinal myeloid cells, may be clinically relevant adjuvants to allergic airway inflammation.

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Trompette A, Gollwitzer ES, Yadava K et al (2014) Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 20:159–166. https://doi.org/10.1038/nm.3444 CrossRef

De Filippo C, Cavalieri D, Di Paola M et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci 107:14691–14696. https://doi.org/10.1073/pnas.1005963107 CrossRef

Loss G, Depner M, Ulfman LH et al (2015) Consumption of unprocessed cow’s milk protects infants from common respiratory infections. J Allergy Clin Immunol 135:56–62. https://doi.org/10.1016/j.jaci.2014.08.044 CrossRefPubMed

Junker Y, Zeissig S, Kim S-J et al (2012) Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 209:2395–2408. https://doi.org/10.1084/jem.20102660 CrossRefPubMedPubMedCentral

Catassi C, Bai JC, Bonaz B et al (2013) Non-celiac gluten sensitivity: the new frontier of gluten related disorders. Nutrients 5:3839–3853. https://doi.org/10.3390/nu5103839 CrossRefPubMedPubMedCentral

Fasano A, Sapone A, Zevallos V, Schuppan D (2015) Nonceliac gluten sensitivity. Gastroenterology 148:1195–1204. https://doi.org/10.1053/j.gastro.2014.12.049 CrossRefPubMed

Wei X, Song H, Yin L et al (2016) Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature 539:294–298. https://doi.org/10.1038/nature20117 CrossRefPubMedPubMedCentral

Schuppan D, Pickert G, Ashfaq-Khan M, Zevallos V (2015) Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol 29:469–476. https://doi.org/10.1016/j.bpg.2015.04.002 CrossRefPubMed

Catassi C, Alaedini A, Bojarski C et al (2017) The overlapping area of non-celiac gluten sensitivity (NCGS) and wheat-sensitive irritable bowel syndrome (IBS): an update. Nutrients. https://doi.org/10.3390/nu9111268 CrossRefPubMedPubMedCentral

10.

Fritscher-Ravens A, Schuppan D, Ellrichmann M et al (2014) Confocal endomicroscopy reveals food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology 147:1012–1020. https://doi.org/10.1053/j.gastro.2014.07.046 CrossRefPubMed

11.

Biesiekierski JR, Peters SL, Newnham ED et al (2013) No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 145(2):320–328. https://doi.org/10.1053/j.gastro.2013.04.051 e1-3.CrossRef

12.

Zevallos VF, Raker V, Tenzer S et al (2017) Nutritional wheat amylase-trypsin inhibitors promote intestinal inflammation via activation of myeloid cells. Gastroenterology 152(5):1100–1113.e12. https://doi.org/10.1053/j.gastro.2016.12.006 CrossRefPubMed

13.

Skodje GI, Sarna VK, Minelle IH et al (2017) Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity. Gastroenterology 154(3):529–539.e2. https://doi.org/10.1053/j.gastro.2017.10.040 CrossRefPubMed

14.

Schuppan D, Zevallos V (2015) Wheat amylase trypsin inhibitors as nutritional activators of innate immunity. Dig Dis 33:260–263. https://doi.org/10.1159/000371476 CrossRefPubMed

15.

Kumar RK, Herbert C, Foster PS (2008) The “classical” ovalbumin challenge model of asthma in mice. Curr Drug Targets 9:485–494. https://doi.org/10.2174/138945008784533561 CrossRefPubMed

16.

Raker V, Stein J, Montermann E et al (2015) Regulation of IgE production and airway reactivity by CD4⁻ CD8⁻ regulatory T cells. Immunobiology 220:490–499. https://doi.org/10.1016/j.imbio.2014.10.022 CrossRefPubMed

17.

Tomioka S, Bates JHT, Irvin CG (2002) Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations. J Appl Physiol 93(1):263–270. https://doi.org/10.1152/japplphysiol.01129.2001 CrossRefPubMed

18.

Tournoy K, Schou P (2000) Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness. Clin Exp Allergy 30:79–85. https://doi.org/10.1046/j.1365-2222.2000.00772.x CrossRefPubMed

19.

Holgate ST (2012) Innate and adaptive immune responses in asthma. Nat Med 18:673–683. https://doi.org/10.1038/nm.2731 CrossRefPubMed

20.

Iwasaki A, Medzhitov R (2015) Control of adaptive immunity by the innate immune system. Nat Immunol 16:343–353. https://doi.org/10.1038/ni.3123 CrossRefPubMedPubMedCentral

21.

Bouchaud G, Gourbeyre P, Bihouee T et al (2015) Consecutive food and respiratory allergies amplify systemic and gut but not lung outcomes in mice. J Agric Food Chem 63(28):6475–6483. https://doi.org/10.1021/acs.jafc.5b02338 CrossRefPubMed

22.

Barnard DE, Lewis SM, Teter BB, Thigpen JE (2009) Open- and closed-formula laboratory animal diets and their importance to research. J Am Assoc Lab Anim Sci 48(6):709–713PubMedPubMedCentral

23.

Libbey JE, Doty DJ, Sim JT et al (2016) The effects of diet on the severity of central nervous system disease: one part of lab-to-lab variability. Nutrition 32(7–8):877–883. https://doi.org/10.1016/j.nut.2016.01.009 CrossRefPubMedPubMedCentral

Titel: Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway inflammation
verfasst von: Victor F. Zevallos
Verena K. Raker
Joachim Maxeiner
Petra Scholtes
Kerstin Steinbrink
Detlef Schuppan
Publikationsdatum: 29.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 4/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1681-6

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Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway inflammation

Abstract

Background

Aim of the study

Methods

Results

Conclusions

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Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Aim of the study

Methods

Results

Conclusions

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