The purpose of this study was to compare the sizes of the placenta and umbilical cord in women with natural pregnancy versus those undergoing in vitro fertilization (IVF).
Overall, 1610 cases of uncomplicated single pregnancies with vaginal delivery at ≥ 37 weeks of gestation were included in this study. The patients were divided into two groups: natural pregnancy group (n = 1453) and IVF pregnancy not including intracytoplasmic sperm injection (ICSI) treatment (n = 157). The groups were compared in terms of gestational week, maternal age, parity, maternal weight gain, prepregnancy maternal BMI, infant weight at birth, infant head circumference, placental weight, cross section of the placenta, cross section of the umbilical cord, insertion site of the umbilical cord, and umbilical cord length. Stepwise selection and multivariate logistic regression were used for statistical analysis to correct the result as an independent factor.
There was no difference in the size of the placenta and umbilical cord between women with natural pregnancy and with IVF, but the incidence of velamentous insertion of the cord was significantly increased in women with IVF pregnancy (adjusted odd ratio [AOR] 1.72, 95% confidence interval [CI] 1.08–2.72, p = 0.026).
Although there is no difference in placental weight and cord size, velamentous insertion of the umbilical cord increases in IVF pregnancy and needs careful observation during the delivery process.
Eskild A, Monkerud L, Tanbo T. Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Human reproduction (Oxford, England). 2013;28(12):3207–14. https://doi.org/10.1093/humrep/det376. CrossRef
Yanaihara A, Yorimitsu T, Motoyama H, Ohara M, Kawamura T. The decrease of serum luteinizing hormone level by a gonadotropin-releasing hormone antagonist following the mild IVF stimulation protocol for IVF and its clinical outcome. J Assist Reprod Genet. 2008;25(4):115–8. https://doi.org/10.1007/s10815-008-9205-6. CrossRefPubMedPubMedCentral
Maheshwari A, Kalampokas T, Davidson J, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of blastocyst-stage versus cleavage-stage embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril. 2013;100(6):1615–1621.e1-10. https://doi.org/10.1016/j.fertnstert.2013.08.044. CrossRefPubMed
Yanaihara A, Ohgi S, Motomura K, Hirano A, Takenaka S, TYanaihara T. In vitro fertilization pregnancy is one of the risk factor for atonic bleeding in problem-free pregnancy. Journal of pregnancy and child health. 2017;4(1):308.
Perry IJ, Beevers DG, Whincup PH, Bareford D. Predictors of ratio of placental weight to fetal weight in multiethnic community. BMJ (Clinical research ed). 1995;310(6977):436–9. CrossRef
Leung TW, Lao TT. Placental size and large-for-gestational-age infants in women with abnormal glucose tolerance in pregnancy. Diabetic medicine : a journal of the British Diabetic Association. 2000;17(1):48–52. CrossRef
Li C, Zhang Y, Tang L, Zhao H, Gao C, Gao L, et al. Expression of factors involved in the regulation of angiogenesis in the full-term human placenta: effects of in vitro fertilization. Reprod Biol. 2016;16(2):104–12. https://doi.org/10.1016/j.repbio.2016.02.003. CrossRefPubMed
Shevell T, Malone FD, Vidaver J, Porter TF, Luthy DA, Comstock CH, et al. Assisted reproductive technology and pregnancy outcome. Obstet Gynecol. 2005;106(5 Pt 1):1039–45. https://doi.org/10.1097/01.AOG.0000183593.24583.7c. CrossRefPubMed
Hasegawa J, Matsuoka R, Ichizuka K, Sekizawa A, Okai T. Velamentous cord insertion: significance of prenatal detection to predict perinatal complications. Taiwanese journal of obstetrics & gynecology. 2006;45(1):21–5. https://doi.org/10.1016/s1028-4559(09)60185-6. CrossRef
- Difference in the size of the placenta and umbilical cord between women with natural pregnancy and those with IVF pregnancy
- Springer US
Journal of Assisted Reproduction and Genetics
An Official Journal of the American Society for Reproductive Medicine
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
Neu im Fachgebiet Gynäkologie und Geburtshilfe
Meistgelesene Bücher aus dem Fachgebiet
e.Med Kampagnen-Visual, Mail Icon II