Differences in medication adherence between preemptive and post-dialysis young kidney transplant recipients
- 10.11.2022
- Original Article
Erschienen in:
- Verfasst von
- Yulia Vaisbourd
- Mourad Dahhou
- Alexia De Simone
- Xun Zhang
- Bethany J. Foster
- Erschienen in
- Pediatric Nephrology | Ausgabe 6/2023
Abstract
Background
The mechanisms underlying the superior graft survival associated with preemptive kidney transplantation, compared with transplantation following a period of dialysis, are unknown. We aimed to compare medication adherence between preemptively transplanted young kidney transplant recipients and those who received a transplant after an interval of dialysis.
Methods
This was a secondary analysis of the Teen Adherence in Kidney transplant Effectiveness of Intervention Trial (TAKE-IT), in which adherence was assessed with electronic monitoring over 15 months among 11–24-year-old transplant recipients. Adherence scores were calculated for each day as 0%, 50%, or 100% (intake of none, half, or all prescribed doses). We used ordinal logistic regression, with generalized estimating equations to account for repeated measures within each participant, to estimate the association between preemptive transplantation and adherence. The model was adjusted for sex, age at transplant, time since transplant, primary kidney disease, race, donor source, medication insurer, household income, and adherence intervention.
Results
There were 43 preemptive transplant recipients and 103 who had been treated with dialysis. The median adherence score was 85.1% (IQR 81.3–88.9) for those preemptively transplanted, and 80.0% (IQR 76.7–83.4) for those transplanted after dialysis. Preemptively transplanted recipients had significantly higher odds of adherence than those dialyzed before transplantation (adjusted OR 1.76 95% CI 1.21–2.55; p = 0.003).
Conclusions
Preemptively transplanted patients showed significantly better adherence than those treated with dialysis before transplantation. This suggests that the superior outcomes observed among preemptive kidney transplant recipients may reflect selection of patients more likely to adhere to therapy.
Graphical abstract
A higher resolution version of the Graphical abstract is available as Supplementary information
Anzeige
- Titel
- Differences in medication adherence between preemptive and post-dialysis young kidney transplant recipients
- Verfasst von
-
Yulia Vaisbourd
Mourad Dahhou
Alexia De Simone
Xun Zhang
Bethany J. Foster
- Publikationsdatum
- 10.11.2022
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Pediatric Nephrology / Ausgabe 6/2023
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X - DOI
- https://doi.org/10.1007/s00467-022-05797-7
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
