The online version of this article (doi:10.1186/1471-2261-14-105) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
All authors have made substantial contributions. KW and HC conducted the design of the study. SS, IC, CS, and GH conducted all clinical measurements. YK and BC conducted all image measurements. KW and JS conducted the statistical analyses. NC reviewed, corrected and helped finalize the manuscript. All authors read and approved the final manuscript.
Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.
We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.
The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.
Additional file 1: Table S1: Comparison of incidence of coronary parameters according to MetSN. (DOC 28 KB)
Additional file 2: Table S2: Impact of individual MetS component on subtypes of coronary plaque according to the diabetes status. (DOC 42 KB)
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- Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population
Young Jin Kim
- BioMed Central
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