nach oben

Erschienen in:

11.03.2019 | Original Paper

Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function

verfasst von: Ignatios Ikonomidis, George Pavlidis, Pelagia Katsimbri, Ioanna Andreadou, Helen Triantafyllidi, Maria Tsoumani, Maria Varoudi, Dimitrios Vlastos, George Makavos, Gavriella Kostelli, Dimitrios Βenas, John Lekakis, John Parissis, Dimitrios Boumpas, Dimitrios Alexopoulos, Efstathios Iliodromitis

Erschienen in: Clinical Research in Cardiology | Ausgabe 10/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

Anakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis. We investigated the differential effects of anakinra and tocilizumab on myocardial and vascular function in an atherosclerosis model of patients with rheumatoid arthritis.

Methods

120 patients with rheumatoid arthritis were randomized to anakinra (n = 40), tocilizumab (n = 40) or prednisolone (n = 40) for 3 months. Primary outcome measure was the change of left ventricular longitudinal strain after 3 months of treatment. Additionally, we measured coronary flow reserve, flow-mediated dilatation of the brachial artery, carotid-femoral pulse wave velocity, malondialdehyde and protein carbonyls as oxidative stress markers and C-reactive protein blood levels at baseline and post-treatment.

Results

At baseline, patients among the three treatment arms had similar age, sex, disease activity score and atherosclerotic risk factors. Compared with baseline, all patients had improved longitudinal strain (− 16% vs. − 17.8%), coronary flow reserve (2.56 vs. 2.9), malondialdehyde (2.0 vs. 1.5 µM/L), protein carbonyls (0.0132 vs. 0.0115 nmol/mg), and C-reactive protein post-treatment. In all patients, the percent decrease of malondialdehyde was correlated with percent increase of longitudinal strain (p < 0.001). Compared with tocilizumab and prednisolone, anakinra treatment resulted in a greater improvement of longitudinal strain (18.7% vs. 9.7% vs. 6%) and coronary flow reserve (29% vs. 13% vs. 1%), while pulse wave velocity and brachial blood pressure were improved only after tocilizumab treatment (11 ± 3 vs. 10.3 ± 2 m/s p < 0.05 for all comparisons).

Conclusions

Anakinra is associated with an improvement in cardiac function and tocilizumab with improvement in vascular function.

Clinical Trial Registration

URL: https://http://www.clinicaltrials.gov. Unique identifier: NCT03288584.

Nur mit Berechtigung zugänglich

Abbate A, Salloum FN, Vecile E, Das A, Hoke NN, Straino S, Biondi-Zoccai GG, Houser JE, Qureshi IZ, Ownby ED, Gustini E, Biasucci LM, Severino A, Capogrossi MC, Vetrovec GW, Crea F, Baldi A, Kukreja RC, Dobrina A (2008) Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction. Circulation 117:2670–2683. https://doi.org/10.1161/CIRCULATIONAHA.107.740233.CrossRefPubMed

Abbate A, Kontos MC, Grizzard JD, Biondi-Zoccai GG, Van Tassell BW, Robati R, Roach LM, Arena RA, Roberts CS, Varma A, Gelwix CC, Salloum FN, Hastillo A, Dinarello CA, Vetrovec GW, VCU-ART Investigators VCU-ART Investigators (2010) Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol 105:1371–1377.e1. https://doi.org/10.1016/j.amjcard.2009.12.059.CrossRefPubMed

Ikonomidis I, Lekakis JP, Nikolaou M, Paraskevaidis I, Andreadou I, Kaplanoglou T, Katsimbri P, Skarantavos G, Soucacos PN, Kremastinos DT (2008) Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. Circulation 117:2662–2669. https://doi.org/10.1161/CIRCULATIONAHA.107.731877.CrossRefPubMed

Ikonomidis I, Tzortzis S, Lekakis J, Paraskevaidis I, Andreadou I, Nikolaou M, Kaplanoglou T, Katsimbri P, Skarantavos G, Soucacos P, Kremastinos DT (2009) Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis. Heart 95:1502–1507. https://doi.org/10.1136/hrt.2009.168971.CrossRefPubMed

Ikonomidis I, Tzortzis S, Andreadou I, Paraskevaidis I, Katseli C, Katsimbri P, Pavlidis G, Parissis J, Kremastinos D, Anastasiou-Nana M, Lekakis J (2014) Increased benefit of interleukin-1 inhibition on vascular function, myocardial deformation, and twisting in patients with coronary artery disease and coexisting rheumatoid arthritis. Circ Cardiovasc Imaging 7:619–628. https://doi.org/10.1161/CIRCIMAGING.113.001193.CrossRefPubMed

del Rincón ID, Williams K, Stern MP, Freeman GL, Escalante A (2001) High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. Arthritis Rheum 44:2737–2745CrossRefPubMed

Libby P (2008) Role of inflammation in atherosclerosis associated with rheumatoid arthritis. Am J Med 121:S21–S31. https://doi.org/10.1016/j.amjmed.2008.06.014.CrossRefPubMed

Groot HE, Al Ali L, van der Horst ICC, Schurer RAJ, van der Werf HW, Lipsic E, van Veldhuisen DJ, Karper JC, van der Harst P (2018) Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction. Clin Res Cardiol. https://doi.org/10.1007/s00392-018-1387-z CrossRefPubMedPubMedCentral

Abraityte A, Aukrust P, Kou L, Anand IS, Young J, Mcmurray JJV, van Veldhuisen DJ, Gullestad L, Ueland T (2018) T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF. Clin Res Cardiol. https://doi.org/10.1007/s00392-018-1331-2 CrossRefPubMed

10.

Shetty A, Hanson R, Korsten P, Shawagfeh M, Arami S, Volkov S, Vila O, Swedler W, Shunaigat AN, Smadi S, Sawaqed R, Perkins D, Shahrara S, Sweiss NJ (2014) Tocilizumab in the treatment of rheumatoid arthritis and beyond. Drug Des Devel Ther 8:349–364. https://doi.org/10.2147/DDDT.S41437.CrossRefPubMedPubMedCentral

11.

Stamatelopoulos KS, Kitas GD, Papamichael CM, Chryssohoou E, Kyrkou K, Georgiopoulos G, Protogerou A, Panoulas VF, Sandoo A, Tentolouris N, Mavrikakis M, Sfikakis PP (2009) Atherosclerosis in rheumatoid arthritis versus diabetes: a comparative study. Arterioscler Thromb Vasc Biol 29:1702–1708. https://doi.org/10.1161/ATVBAHA.109.190108.CrossRefPubMed

12.

Cioffi G, Viapiana O, Ognibeni F, Dalbeni A, Giollo A, Gatti D, Idolazzi L, Faganello G, Di Lenarda A, Rossini M (2017) Prognostic role of subclinical left ventricular systolic dysfunction evaluated by speckle-tracking echocardiography in rheumatoid arthritis. J Am Soc Echocardiogr 30:602–611. https://doi.org/10.1016/j.echo.2017.02.001.CrossRefPubMed

13.

Schuh A, Karayusuf V, Altiok E, Hamada S, Schröder J, Keszei A, Kelm M, de la Fuente M, Frick M, Radermacher K, Marx N, Becker M (2017) Erratum to: intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory. Clin Res Cardiol 106:850. https://doi.org/10.1007/s00392-017-1125-y CrossRefPubMed

14.

Schuh A, Karayusuf V, Altiok E, Hamada S, Schröder J, Keszei A, Kelm M, de la Fuente M, Frick M, Radermacher K, Marx N, Becker M (2017) Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory. Clin Res Cardiol 106:629–644. https://doi.org/10.1007/s00392-017-1099-9 CrossRefPubMed

15.

Schroeder J, Hamada S, Gründlinger N, Rubeau T, Altiok E, Ulbrich K, Keszei A, Marx N, Becker M (2016) Myocardial deformation by strain echocardiography identifies patients with acute coronary syndrome and non-diagnostic ECG presenting in a chest pain unit: a prospective study of diagnostic accuracy. Clin Res Cardiol 105:248–256. https://doi.org/10.1007/s00392-015-0916-2 CrossRefPubMed

16.

Protogerou AD, Zampeli E, Fragiadaki K, Stamatelopoulos K, Papamichael C, Sfikakis PP (2011) A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis. Atherosclerosis 219:734–736. https://doi.org/10.1016/j.atherosclerosis.2011.09.015.CrossRefPubMed

17.

Kobayashi Y, Kobayashi H, Giles JT, Hirano M, Nakajima Y, Takei M (2016) Association of tocilizumab treatment with changes in measures of regional left ventricular function in rheumatoid arthritis, as assessed by cardiac magnetic resonance imaging. Int J Rheum Dis 19:1169–1174. https://doi.org/10.1111/1756-185X.12632.CrossRefPubMed

18.

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580–1588. https://doi.org/10.1136/ard.2010.138461.CrossRefPubMed

19.

Sokka T, Kankainen A, Hannonen P (2000) Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores. Arthritis Rheum 43:386–389CrossRefPubMed

20.

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16:233–270. https://doi.org/10.1093/ehjci/jev014.CrossRefPubMed

21.

Ikonomidis I, Lekakis J, Papadopoulos C, Triantafyllidi H, Paraskevaidis I, Georgoula G, Tzortzis S, Revela I, Kremastinos DT (2008) Incremental value of pulse wave velocity in the determination of coronary microcirculatory dysfunction in never-treated patients with essential hypertension. Am J Hypertens 21:806–813. https://doi.org/10.1038/ajh.2008.172.CrossRefPubMed

22.

Völz S, Svedlund S, Andersson B, Li-Ming G, Rundqvist B (2017) Coronary flow reserve in patients with resistant hypertension. Clin Res Cardiol 106:151–157. https://doi.org/10.1007/s00392-016-1043-4 CrossRefPubMed

23.

Fengler K, Rommel KP, Blazek S, Von Roeder M, Besler C, Lücke C, Gutberlet M, Steeden J, Quail M, Desch S, Thiele H, Muthurangu V, Lurz P (2018) Cardiac magnetic resonance assessment of central and peripheral vascular function in patients undergoing renal sympathetic denervation as predictor for blood pressure response. Clin Res Cardiol. https://doi.org/10.1007/s00392-018-1267-6 CrossRefPubMed

24.

Massmann A, Stemler J, Fries P, Kubale R, Kraushaar LE, Buecker A (2017) Automated oscillometric blood pressure and pulse-wave acquisition for evaluation of vascular stiffness in atherosclerosis. Clin Res Cardiol 106:514–524. https://doi.org/10.1007/s00392-017-1080-7 CrossRefPubMedPubMedCentral

25.

Gronda E, Brambilla G, Seravalle G, Maloberti A, Cairo M, Costantino G, Lovett E, Vanoli E, Mancia G, Grassi G (2016) Effects of chronic carotid baroreceptor activation on arterial stiffness in severe heart failure. Clin Res Cardiol 105:838–846. https://doi.org/10.1007/s00392-016-0992-y CrossRefPubMed

26.

Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, De Buyzere M, De Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D, Mahrholdt H, Olsen MH, Ostergren J, Parati G, Perk J, Polonia J, Popescu BA, Reiner Z, Rydén L, Sirenko Y, Stanton A, Struijker-Boudier H, Tsioufis C, van de Borne P, Vlachopoulos C, Volpe M, Wood DA (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34:2159–2219. https://doi.org/10.1093/eurheartj/eht151 CrossRefPubMed

27.

Baier D, Teren A, Wirkner K, Loeffler M, Scholz M (2018) Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult. Clin Res Cardiol. https://doi.org/10.1007/s00392-018-1278-3 CrossRefPubMedPubMedCentral

28.

Sokolove J, Johnson DS, Lahey LJ, Wagner CA, Cheng D, Thiele GM, Michaud K, Sayles H, Reimold AM, Caplan L, Cannon GW, Kerr G, Mikuls TR, Robinson WH (2014) Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis. Arthritis Rheumatol 66:813–821. https://doi.org/10.1002/art.38307.CrossRefPubMedPubMedCentral

29.

Ikonomidis I, Makavos G, Papadavid E, Varoudi M, Andreadou I, Gravanis K, Theodoropoulos K, Pavlidis G, Triantafyllidi H, Parissis J, Paraskevaidis I, Rigopoulos D, Lekakis J (2015) Similarities in coronary function and myocardial deformation between psoriasis and coronary artery disease: the role of oxidative stress and inflammation. Can J Cardiol 31:287–295. https://doi.org/10.1016/j.cjca.2014.11.002.CrossRefPubMed

30.

Parissis JT, Kourea K, Andreadou I, Ikonomidis I, Markantonis S, Ioannidis K, Paraskevaidis I, Iliodromitis E, Filippatos G, Kremastinos DT (2009) Effects of Darbepoetin Alfa on plasma mediators of oxidative and nitrosative stress in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 103:1134–1138. https://doi.org/10.1016/j.amjcard.2008.12.041.CrossRefPubMed

31.

Zell R, Geck P, Werdan K, Boekstegers P (1997) TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function. Mol Cell Biochem 177:61–67CrossRefPubMed

32.

Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Can J Cardiol 32:659–668. https://doi.org/10.1016/j.cjca.2016.02.070.CrossRefPubMedPubMedCentral

33.

Kossakowska AE, Edwards DR, Prusinkiewicz C, Zhang MC, Guo D, Urbanski SJ, Grogan T, Marquez LA, Janowska-Wieczorek A (1999) Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin’s lymphomas. Blood 94:2080–2089CrossRef

34.

Zhang XL, Topley N, Ito T, Phillips A (2005) Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 280:12239–12245CrossRefPubMed

35.

An Z, Qiao F, Lu Q, Ma Y, Liu Y, Lu F, Xu Z (2017) Interleukin-6 downregulated vascular smooth muscle cell contractile proteins via ATG4B-mediated autophagy in thoracic aortic dissection. Heart Vessels 32:1523–1535CrossRefPubMed

36.

Ciftci O, Yilmaz S, Topcu S, Caliskan M, Gullu H, Erdogan D, Pamuk BO, Yildirir A, Muderrisoglu H (2008) Impaired coronary microvascular function and increased intima-media thickness in rheumatoid arthritis. Atherosclerosis 198:332–337. https://doi.org/10.1016/j.atherosclerosis.2007.11.013.CrossRefPubMed

37.

Raza K, Banks M, Kitas GD (2005) Reversing myocardial microvascular disease in a patient with rheumatoid arthritis. J Rheumatol 32:754–756PubMed

38.

Klemm P, Warner TD, Corder R, Vane JR (1995) Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines. J Cardiovasc Pharmacol 26:S419–S421CrossRefPubMed

39.

Hashizume M, Yoshida H, Koike N, Suzuki M, Mihara M (2010) Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor. Ann Rheum Dis 69:741–746. https://doi.org/10.1136/ard.2008.104844.CrossRefPubMed

40.

Hashizume M, Mihara M (2012) Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors. Cytokine 58:424–430. https://doi.org/10.1016/j.cyto.2012.02.010.CrossRefPubMed

41.

Carpentier YA, Scruel O (2002) Changes in the concentration and composition of plasma lipoproteins during the acute phase response. Curr Opin Clin Nutr Metab Care 5:153–158CrossRefPubMed

42.

Choy E, Sattar N (2009) Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. Ann Rheum Dis 68:460–469. https://doi.org/10.1136/ard.2008.101964.CrossRefPubMed

43.

McInnes IB, Thompson L, Giles JT, Bathon JM, Salmon JE, Beaulieu AD, Codding CE, Carlson TH, Delles C, Lee JS, Sattar N (2015) Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study. Ann Rheum Dis 74:694–702. https://doi.org/10.1136/annrheumdis-2013-204345.CrossRefPubMed

44.

Sironi M, Breviario F, Proserpio P, Biondi A, Vecchi A, Van Damme J, Dejana E, Mantovani A (1989) IL-1 stimulates IL-6 production in endothelial cells. J Immunol 142:549–553PubMed

45.

Ikonomidis I, Athanassopoulos G, Lekakis J, Venetsanou K, Marinou M, Stamatelopoulos K, Cokkinos DV, Nihoyannopoulos P (2005) Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. Circulation 112:3272–3279CrossRefPubMed

46.

Verhoeven F, Prati C, Maguin-Gaté K, Wendling D, Demougeot C (2016) Glucocorticoids and endothelial function in inflammatory diseases: focus on rheumatoid arthritis. Arthritis Res Ther 18:258. https://doi.org/10.1186/s13075-016-1157-0 CrossRefPubMedPubMedCentral

47.

del Rincón I, Battafarano DF, Restrepo JF, Erikson JM, Escalante A (2014) Glucocorticoid dose thresholds associated with all-cause and cardiovascular mortality in rheumatoid arthritis. Arthritis Rheumatol 66:264–272. https://doi.org/10.1002/art.38210 CrossRefPubMed

48.

Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, CANTOS Trial Group (2017) Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 377:1119–1131. https://doi.org/10.1056/NEJMoa1707914 CrossRefPubMed

49.

Kleveland O, Kunszt G, Bratlie M, Ueland T, Broch K, Holte E, Michelsen AE, Bendz B, Amundsen BH, Espevik T, Aakhus S, Damås JK, Aukrust P, Wiseth R, Gullestad L (2016) Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. Eur Heart J 37:2406–2413. https://doi.org/10.1093/eurheartj/ehw171.CrossRefPubMed

50.

Chen YR, Hsieh FI, Chang CC, Chi NF, Wu HC, Chiou HY (2018) Effect on risk of stroke and acute myocardial infarction of nonselective nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis. Am J Cardiol 121:1271–1277. https://doi.org/10.1016/j.amjcard.2018.01.044.CrossRefPubMed

Titel: Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function
verfasst von: Ignatios Ikonomidis
George Pavlidis
Pelagia Katsimbri
Ioanna Andreadou
Helen Triantafyllidi
Maria Tsoumani
Maria Varoudi
Dimitrios Vlastos
George Makavos
Gavriella Kostelli
Dimitrios Βenas
John Lekakis
John Parissis
Dimitrios Boumpas
Dimitrios Alexopoulos
Efstathios Iliodromitis
Publikationsdatum: 11.03.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 10/2019
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-019-01443-9

Neu im Fachgebiet Kardiologie

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function

Abstract

Background

Methods

Results

Conclusions

Clinical Trial Registration

Neu im Fachgebiet Kardiologie

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Parodontalbehandlung verbessert Prognose bei Katheterablation

Update Kardiologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Clinical Trial Registration

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2019

Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study

Sacubitril/valsartan reduces ventricular arrhythmias in parallel with left ventricular reverse remodeling in heart failure with reduced ejection fraction

Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Implant-based multi-parameter telemonitoring of patients with heart failure and a defibrillator with vs. without cardiac resynchronization therapy option: a subanalysis of the IN-TIME trial

Neu im Fachgebiet Kardiologie

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Parodontalbehandlung verbessert Prognose bei Katheterablation

Update Kardiologie