Skip to main content
Erschienen in: Journal of Cancer Research and Clinical Oncology 10/2003

01.10.2003 | Original Paper

Differential enhancement of collagen crosslink excretion in cases of osteosarcoma and chondrosarcoma

verfasst von: Yahya Açil, Ingo Springer, Peter Behrens, Klaus-Peter Ullrich, Juergen Hedderich, Juergen Bruns

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2003

Einloggen, um Zugang zu erhalten

Abstract.

Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma (n=20; age range 16–49 years) and chondrosarcoma (n=15; age range 18–70 years). The values were compared with those obtained from 74 healthy controls (age range 16–83 years). The range and upper limit of normal values (HPmax and LPmax) were measured in our control group. High performance liquid chromatography (HPLC) was used to determine concentrations of HP and LP (nmol/mmol creatinine). The average urinary HP concentrations were significantly increased in patients with osteosarcoma (p=0.001) and chondrosarcoma (p<0.001), whereas HP remained within the normal range in approximately half of the patients. The average urinary LP concentrations were not increased in osteosarcoma and chondrosarcoma patients as compared with the control group. Further studies in a large group of patients are necessary to evaluate whether HP might be a valuable marker of prognosis, and if its urinary concentration can be correlated to tumour burden.
Literatur
Zurück zum Zitat Acil Y, Müller PK (1994) A rapid method for the isolation of the mature collagen cross-links, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). J Chromatogr A 664:183–188 Acil Y, Müller PK (1994) A rapid method for the isolation of the mature collagen cross-links, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). J Chromatogr A 664:183–188
Zurück zum Zitat Acil Y, Vetter U, Brenner R, Muller PK, Brinckmann J (1995) Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker. J Am Acad Dermatol 33:522–524PubMed Acil Y, Vetter U, Brenner R, Muller PK, Brinckmann J (1995) Ehlers-Danlos syndrome type VI: cross-link pattern in tissue and urine sample as a diagnostic marker. J Am Acad Dermatol 33:522–524PubMed
Zurück zum Zitat Acil Y, Brinckmann J, Notbohm H, Muller PK, Batge B (1996) Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) Scand J Clin Lab Invest 56:275–283 Acil Y, Brinckmann J, Notbohm H, Muller PK, Batge B (1996) Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) Scand J Clin Lab Invest 56:275–283
Zurück zum Zitat Acil Y, Terheyden H, Dunsche A, Fleiner B, Jepsen S (2000) Three-dimensional cultivation of human osteoblast-like cells on highly porous natural bone mineral. J Biomed Mater Res 51:703–710PubMed Acil Y, Terheyden H, Dunsche A, Fleiner B, Jepsen S (2000) Three-dimensional cultivation of human osteoblast-like cells on highly porous natural bone mineral. J Biomed Mater Res 51:703–710PubMed
Zurück zum Zitat Acil Y, Springer ING, Prasse JG, Hedderich J, Jepsen S (2002) Concentration of collagen cross-links in human dentin bears no relation to the individual age. Int J Legal Med 116:340–343PubMed Acil Y, Springer ING, Prasse JG, Hedderich J, Jepsen S (2002) Concentration of collagen cross-links in human dentin bears no relation to the individual age. Int J Legal Med 116:340–343PubMed
Zurück zum Zitat Akesson K (1995) Biochemical markers of bone turnover. A review. Acta Orthop Scand 66:376–386PubMed Akesson K (1995) Biochemical markers of bone turnover. A review. Acta Orthop Scand 66:376–386PubMed
Zurück zum Zitat Body JJ, Delmas PD (1992) Urinary pyridinium cross-links as markers of bone resorption in tumor-associated hypercalcemia. J Clin Endocrinol Metab 74:471–475 Body JJ, Delmas PD (1992) Urinary pyridinium cross-links as markers of bone resorption in tumor-associated hypercalcemia. J Clin Endocrinol Metab 74:471–475
Zurück zum Zitat Branca F, Robins SP, Ferro-Luzzi A, Golden MH (1992) Bone turnover in malnourished children. Lancet 340:1493–1496PubMed Branca F, Robins SP, Ferro-Luzzi A, Golden MH (1992) Bone turnover in malnourished children. Lancet 340:1493–1496PubMed
Zurück zum Zitat Bull H, Murray PG, Thomas D, Fraser AM, Nelson PN (2002) Acid phosphatases. Mol Pathol 55:65–72CrossRefPubMed Bull H, Murray PG, Thomas D, Fraser AM, Nelson PN (2002) Acid phosphatases. Mol Pathol 55:65–72CrossRefPubMed
Zurück zum Zitat Coleman RE, Purohit OP, Black C, Vinholes JJ, Schlosser K, Huss H, Quinn KJ, Kanis J (1999) Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease. Ann Oncol 10:311–316 Coleman RE, Purohit OP, Black C, Vinholes JJ, Schlosser K, Huss H, Quinn KJ, Kanis J (1999) Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease. Ann Oncol 10:311–316
Zurück zum Zitat Davis GJ, Kapatkin AS, Craig LE, Heins GS, Wortman JA (2002) Comparison of radiography, computed tomography, and magnetic resonance imaging for evaluation of appendicular osteosarcoma in dogs. J Am Vet Med Assoc 220:1171–1176PubMed Davis GJ, Kapatkin AS, Craig LE, Heins GS, Wortman JA (2002) Comparison of radiography, computed tomography, and magnetic resonance imaging for evaluation of appendicular osteosarcoma in dogs. J Am Vet Med Assoc 220:1171–1176PubMed
Zurück zum Zitat Delmas PD (1992) Clinical use of biochemical markers of bone remodeling in osteoporosis. Bone 13:S17–S21 Delmas PD (1992) Clinical use of biochemical markers of bone remodeling in osteoporosis. Bone 13:S17–S21
Zurück zum Zitat Demers LM, Costa L, Lipton A (2000) Biochemical markers and skeletal metastases. Cancer 88:2919–2926CrossRefPubMed Demers LM, Costa L, Lipton A (2000) Biochemical markers and skeletal metastases. Cancer 88:2919–2926CrossRefPubMed
Zurück zum Zitat Eyre D (1992) New biomarkers of bone resorption. J Clin Endocrinol Metab 74:470A–470C Eyre D (1992) New biomarkers of bone resorption. J Clin Endocrinol Metab 74:470A–470C
Zurück zum Zitat Fontana A, Delmas PD (2000) Markers of bone turnover in bone metastases. Cancer 88:2952–2960CrossRefPubMed Fontana A, Delmas PD (2000) Markers of bone turnover in bone metastases. Cancer 88:2952–2960CrossRefPubMed
Zurück zum Zitat Hoskin PJ, Stratford MR, Folkes LK, Regan J, Yarnold JR (2000) Effect of local radiotherapy for bone pain on urinary markers of osteoclast activity. Lancet 355:1428–1429PubMed Hoskin PJ, Stratford MR, Folkes LK, Regan J, Yarnold JR (2000) Effect of local radiotherapy for bone pain on urinary markers of osteoclast activity. Lancet 355:1428–1429PubMed
Zurück zum Zitat Izumi M, Nakanishi Y, Takayama K, Kimotsuki K, Inoue K, Wataya H, Minami T, Hara N (2001) Diagnostic value of bone-turnover metabolites in the diagnosis of bone metastases in patients with lung carcinoma. Cancer 91:1487–1493CrossRefPubMed Izumi M, Nakanishi Y, Takayama K, Kimotsuki K, Inoue K, Wataya H, Minami T, Hara N (2001) Diagnostic value of bone-turnover metabolites in the diagnosis of bone metastases in patients with lung carcinoma. Cancer 91:1487–1493CrossRefPubMed
Zurück zum Zitat Liesegang A, Ursprung R, Gasser J, Sassi ML, Risteli J, Riond JL, Wanner M (2002) Influence of dietary phosphorus deficiency with or without addition of fumaric acid to a diet in pigs on bone parameters. J Anim Physiol Anim Nutr (Berl) 86:1–16 Liesegang A, Ursprung R, Gasser J, Sassi ML, Risteli J, Riond JL, Wanner M (2002) Influence of dietary phosphorus deficiency with or without addition of fumaric acid to a diet in pigs on bone parameters. J Anim Physiol Anim Nutr (Berl) 86:1–16
Zurück zum Zitat Liubimova NV, Bronnikov II, Robins SP, Trapeznikova MF, Kushlinskii NE (2000) The biochemical markers of bone remodeling in cancer patients with skeletal involvement. Vopr Onkol 46:290–297PubMed Liubimova NV, Bronnikov II, Robins SP, Trapeznikova MF, Kushlinskii NE (2000) The biochemical markers of bone remodeling in cancer patients with skeletal involvement. Vopr Onkol 46:290–297PubMed
Zurück zum Zitat Marttunen MB, Hietanen P, Titinen A, Roth HJ, Viinikka L, Ylikorkala O (1999) Effects of tamoxifen and toremifene on urinary excretion of pyridinoline and deoxypyridinoline and bone density in postmenopausal patients with breast cancer. Calcif Tissue Int 65:365–368CrossRefPubMed Marttunen MB, Hietanen P, Titinen A, Roth HJ, Viinikka L, Ylikorkala O (1999) Effects of tamoxifen and toremifene on urinary excretion of pyridinoline and deoxypyridinoline and bone density in postmenopausal patients with breast cancer. Calcif Tissue Int 65:365–368CrossRefPubMed
Zurück zum Zitat Meyer S, Reinhard H, Graf N, Puschel W, Ziegler K, Schneider G (2002) The importance of conventional radiographs in the diagnosis of osteosarcoma. Klin Padiatr 214:58–61CrossRefPubMed Meyer S, Reinhard H, Graf N, Puschel W, Ziegler K, Schneider G (2002) The importance of conventional radiographs in the diagnosis of osteosarcoma. Klin Padiatr 214:58–61CrossRefPubMed
Zurück zum Zitat Papatheofanis FJ (1997) Quantitation of biochemical markers of bone resorption following strontium-89-chloride therapy for metastatic prostatic carcinoma. J Nucl Med 38:1175–1179PubMed Papatheofanis FJ (1997) Quantitation of biochemical markers of bone resorption following strontium-89-chloride therapy for metastatic prostatic carcinoma. J Nucl Med 38:1175–1179PubMed
Zurück zum Zitat Pecherstorfer M, Zimmer-Roth I, Schilling T, Woitge HW, Schmidt H, Baumgartner G, Thiebaud D, Ludwig H, Seibel MJ (1995) The diagnostic value of urinary pyridinium cross-links of collagen, serum total alkaline phosphatase, and urinary calcium excretion in neoplastic bone disease. J Clin Endocrinol Metab 80:97–103PubMed Pecherstorfer M, Zimmer-Roth I, Schilling T, Woitge HW, Schmidt H, Baumgartner G, Thiebaud D, Ludwig H, Seibel MJ (1995) The diagnostic value of urinary pyridinium cross-links of collagen, serum total alkaline phosphatase, and urinary calcium excretion in neoplastic bone disease. J Clin Endocrinol Metab 80:97–103PubMed
Zurück zum Zitat Saifuddin A (2002) The accuracy of imaging in the local staging of appendicular osteosarcoma. Skeletal Radiol 31:191–201CrossRefPubMed Saifuddin A (2002) The accuracy of imaging in the local staging of appendicular osteosarcoma. Skeletal Radiol 31:191–201CrossRefPubMed
Zurück zum Zitat Springer ING, Suhr M, Fleiner B (2002) Adaptive adjustment of the adolescent porcine mandibular condyle. Bone 31:1190–1195CrossRef Springer ING, Suhr M, Fleiner B (2002) Adaptive adjustment of the adolescent porcine mandibular condyle. Bone 31:1190–1195CrossRef
Zurück zum Zitat Springer ING, Terheyden H, Dunsche A, Czech N, Tiemann M, Hedderich J, Açil Y (2003) Collagen crosslink excretion and staging of oral cancer. Br J Cancer 88:1105–1110CrossRefPubMed Springer ING, Terheyden H, Dunsche A, Czech N, Tiemann M, Hedderich J, Açil Y (2003) Collagen crosslink excretion and staging of oral cancer. Br J Cancer 88:1105–1110CrossRefPubMed
Zurück zum Zitat Stone PJ, Bryan-Rhadfi J, Shaw HA, Franzblau C (1992) Isolation of hydroxylysyl pyridinoline, a mature collagen crosslink from neonatal rat aorta smooth muscle cell cultures. Matrix 12:381–387PubMed Stone PJ, Bryan-Rhadfi J, Shaw HA, Franzblau C (1992) Isolation of hydroxylysyl pyridinoline, a mature collagen crosslink from neonatal rat aorta smooth muscle cell cultures. Matrix 12:381–387PubMed
Zurück zum Zitat Takeuchi S, Arai K, Saitoh H, Yoshida K, Miura M (1996) Urinary pyridinoline and deoxypyridinoline as potential markers of bone metastasis in patients with prostate cancer. J Urol 156:1691–1695PubMed Takeuchi S, Arai K, Saitoh H, Yoshida K, Miura M (1996) Urinary pyridinoline and deoxypyridinoline as potential markers of bone metastasis in patients with prostate cancer. J Urol 156:1691–1695PubMed
Zurück zum Zitat Tamada T, Sone T, Tomomitsu T, Jo Y, Tanaka H, Fukunaga M (2001) Biochemical markers for the detection of bone metastasis in patients with prostate cancer: diagnostic efficacy and the effect of hormonal therapy. J Bone Miner Metab 19:45–51PubMed Tamada T, Sone T, Tomomitsu T, Jo Y, Tanaka H, Fukunaga M (2001) Biochemical markers for the detection of bone metastasis in patients with prostate cancer: diagnostic efficacy and the effect of hormonal therapy. J Bone Miner Metab 19:45–51PubMed
Zurück zum Zitat Tamura H, Ishii S, Ikeda T, Enomoto K, Kitajima M (1999) The relationship between urinary pyridinoline, deoxypyridinoline and bone metastasis in a rat breast cancer model. Breast Cancer 6:23–28PubMed Tamura H, Ishii S, Ikeda T, Enomoto K, Kitajima M (1999) The relationship between urinary pyridinoline, deoxypyridinoline and bone metastasis in a rat breast cancer model. Breast Cancer 6:23–28PubMed
Zurück zum Zitat Vinholes J, Guo CY, Purohit OP, Eastell R, Coleman RE (1996) Metabolic effects of pamidronate in patients with metastatic bone disease. Br J Cancer 73:1089–1095PubMed Vinholes J, Guo CY, Purohit OP, Eastell R, Coleman RE (1996) Metabolic effects of pamidronate in patients with metastatic bone disease. Br J Cancer 73:1089–1095PubMed
Zurück zum Zitat Walls J, Assiri A, Howell A, Rogers E, Ratcliffe WA, Eastell R, Bundred NJ (1999) Measurement of urinary collagen cross-links indicate response to therapy in patients with breast cancer and bone metastases. Br J Cancer 80:1265–1270CrossRefPubMed Walls J, Assiri A, Howell A, Rogers E, Ratcliffe WA, Eastell R, Bundred NJ (1999) Measurement of urinary collagen cross-links indicate response to therapy in patients with breast cancer and bone metastases. Br J Cancer 80:1265–1270CrossRefPubMed
Zurück zum Zitat Walne AJ, Jenkins PJ, James IT, Plowman PN (1997) Pyridinium crosslinks in the monitoring of patients with bone metastases from carcinoma of the breast. Clin Oncol 9:30–34 Walne AJ, Jenkins PJ, James IT, Plowman PN (1997) Pyridinium crosslinks in the monitoring of patients with bone metastases from carcinoma of the breast. Clin Oncol 9:30–34
Zurück zum Zitat Wittig JC, Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM (2002) Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Am Fam Physician 65:1123–1132PubMed Wittig JC, Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM (2002) Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Am Fam Physician 65:1123–1132PubMed
Zurück zum Zitat Woitge HW, Pecherstorfer M, Li Y, Keck AV, Horn E, Ziegler R, Seibel MJ (1999) Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices. J Bone Miner Res 14:792–801PubMed Woitge HW, Pecherstorfer M, Li Y, Keck AV, Horn E, Ziegler R, Seibel MJ (1999) Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices. J Bone Miner Res 14:792–801PubMed
Zurück zum Zitat Woitge HW, Pecherstorfer M, Horn E, Keck AV, Diel IJ, Bayer P, Ludwig H, Ziegler R, Seibel MJ (2001) Serum bone sialoprotein as a marker of tumour burden and neoplastic bone involvement and as a prognostic factor in multiple myeloma. Br J Cancer 84:344–351CrossRefPubMed Woitge HW, Pecherstorfer M, Horn E, Keck AV, Diel IJ, Bayer P, Ludwig H, Ziegler R, Seibel MJ (2001) Serum bone sialoprotein as a marker of tumour burden and neoplastic bone involvement and as a prognostic factor in multiple myeloma. Br J Cancer 84:344–351CrossRefPubMed
Metadaten
Titel
Differential enhancement of collagen crosslink excretion in cases of osteosarcoma and chondrosarcoma
verfasst von
Yahya Açil
Ingo Springer
Peter Behrens
Klaus-Peter Ullrich
Juergen Hedderich
Juergen Bruns
Publikationsdatum
01.10.2003
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 10/2003
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-003-0470-6

Weitere Artikel der Ausgabe 10/2003

Journal of Cancer Research and Clinical Oncology 10/2003 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.