Background
Methods
Patients and tissue specimens
Immunohistochemistry
Review and scoring of stained tissue sections
Statistical analysis
Results
Expression patterns of ERα and ERβ1 in female PTC patients
PTC (n = 50) | NTG (n = 30) |
P-value | |||
---|---|---|---|---|---|
ERα
|
Positive percentage
| 30/50 (60.0%) | 2/30 (6.7%) | 0.000 | |
Total score
b
| 3.44 ± 2.80 | 0.27 ± 1.05 | 0.000 | ||
Subcellular localization
| Nu | 22/30 (73.3%) | 2/2 (100%) | 0.000 | |
Nu + Cyto | 6/30 (20.0%) | 0 | |||
Cyto | 2/30 (6.7%) | 0 | |||
ERβ1
|
Positive percentage
| 48/50 (96.0%) | 28/30 (93.3%) | 0.596 | |
Total score
| 6.36 ± 1.64 | 7.03 ± 1.85 | 0.001 | ||
Subcellular localization
| Nu | 7/48 (14.6%) | 23/28 (82.1%) | 0.000 | |
Nu + Cyto | 36/48 (75.0%) | 5/28 (17.9%) | |||
Cyto | 5/48 (10.4%) | 0 |
Reproductive age (n = 50) | Advanced reproductive age (n = 39) |
P-value | |||
---|---|---|---|---|---|
ERα
|
Positive percentage
| 30/50 (60.0%) | 18/39 (46.2%) | 0.194 | |
Total score
b
| 3.44 ± 2.80 | 2.92 ± 3.35 | 0.342 | ||
Subcellular localization
| Nu | 22/30 (73.3%) | 7/18 (38.9%) | 0.011 | |
Nu + Cyto | 6/30 (20.0%) | 3/18 (16.7%) | |||
Cyto | 2/30 (6.7%) | 8/18 (44.4%) | |||
ERβ1
|
Positive percentage
| 48/50 (96.0%) | 39/39 (100%) | 0.206 | |
Total score
| 6.36 ± 1.64 | 6.69 ± 1.10 | 0.391 | ||
Subcellular localization
| Nu | 7/48 (14.6%) | 3/39 (7.7%) | 0.404 | |
Nu + Cyto | 36/48 (75.0%) | 30/39 (76.9%) | |||
Cyto | 5/48 (10.4%) | 6/39 (15.4%) |
Relationships between ERα/ERβ1 expression and clinicopathological/biological factors in female PTC patients
Relationships between subcellular localization of ERα/ERβ1 and clinicopathological/biological factors in female PTC patients
ERα | Tumor size | LNM | ETE | TNM | ||||
---|---|---|---|---|---|---|---|---|
≤20 mm | >20 mm | + | - | + | - | I/II | III/IV | |
Reproductive age
a
| ||||||||
Nu (n = 28) | 16/28 (57.1%) | 12/28 (42.9%) | 15/28 (53.6%) | 13/28 (46.4%) | 10/28 (35.7%) | 18/28 (64.3%) | 25/28 (89.3%) | 3/28 (10.7%) |
Nu + Cyto/Cyto (n = 8) | 3/8 (37.5%) | 5/8 (62.5%) | 4/8 (50.0%) | 4/8 (50.0%) | 0 | 8/8 (100%) | 8/8 (100%) | 0 |
P-value | 0.908 | 0.858 | 0.047 | 0.334 | ||||
Advanced reproductive age
b
| ||||||||
Nu (n = 7) | 5/7 (71.4%) | 2/7 (28.6%) | 2/7 (28.6%) | 5/7 (71.4%) | 4/7 (57.1%) | 3/7 (42.9%) | 4/7 (57.1%) | 3/7 (42.9%) |
Nu + Cyto/Cyto (n = 11) | 4/11 (36.4%) | 7/11 (63.6%) | 5/11 (45.5%) | 6/11 (54.5%) | 2/11 (18.2%) | 9/11 (81.8%) | 6/11 (54.5%) | 5/11 (45.5%) |
P-value | 0.109 | 0.474 | 0.087 | 0.914 | ||||
ERβ1
|
Tumor size
|
LNM
|
ETE
|
TNM
| ||||
≤20 mm
|
>20 mm
|
+
|
-
|
+
|
-
|
I/II
|
III/IV
| |
Reproductive age
| ||||||||
Nu (n = 7) | 5/7 (71.4%) | 2/7 (28.6%) | 2/7 (28.6%) | 5/7 (71.4%) | 1/7 (14.3%) | 6/7 (85.7%) | 7/7 (100%) | 0 |
Nu + Cyto/Cyto (n = 41) | 19/41 (46.3%) | 22/41 (53.7%) | 25/41 (61.0%) | 16/41 (39.0%) | 15/41 (36.6%) | 26/41 (63.4%) | 38/41 (92.7%) | 3/41 (7.3%) |
P-value | 0.374 | 0.110 | 0.247 | 0.460 | ||||
Advanced reproductive age
| ||||||||
Nu (n = 3) | 2/3 (66.7%) | 1/3 (33.3%) | 0 | 3/3 (100%) | 0 | 3/3 (100%) | 3/3 (100%) | 0 |
Nu + Cyto/Cyto(n = 36) | 14/36 (38.9%) | 22/36 (61.1%) | 16/36 (44.4%) | 20/36 (55.5%) | 16/36 (44.4%) | 20/36 (55.5%) | 16/36 (44.4%) | 20/36 (55.5%) |
P-value | 0.300 | 0.133 | 0.133 | 0.064 |
ERα | Ki-67 | Mutant P53 | VEGF | |||
---|---|---|---|---|---|---|
Reproductive agea
| ||||||
Subcellular localization | Positive percentage | Total scorec
| Positive percentage | Total score | Positive percentage | Total score |
Nu (n = 28) | 27/28 (96.4%) | 4.04 ± 1.07 | 21/28 (75.0%) | 4.75 ± 2.98 | 26/28 (92.9%) | 5.93 ± 2.14 |
Nu + Cyto/Cyto (n = 8) | 8/8 (100%) | 4.13 ± 0.64 | 5/8 (62.5%) | 3.88 ± 3.36 | 8/8 (100%) | 5.88 ± 1.81 |
P-value | 0.588 | 0.983 | 0.486 | 0.562 | 0.437 | 0.683 |
Advanced reproductive age
b
| ||||||
Nu (n = 7) | 6/7 (85.7%) | 3.43 ± 1.51 | 4/7 (57.1%) | 3.71 ± 3.50 | 3/7 (42.9%) | 2.29 ± 3.09 |
Nu + Cyto/Cyto (n = 11) | 8/11 (72.7%) | 3.55 ± 2.30 | 8/11 (72.7%) | 5.18 ± 3.37 | 8/11 (72.7%) | 4.09 ± 3.05 |
P-value | 0.518 | 0.121 | 0.494 | 0.182 | 0.205 | 0.205 |
ERβ1
|
Ki-67
|
Mutant P53
|
VEGF
| |||
Reproductive age
| ||||||
Subcellular localization
|
Positive percentage
|
Total score
|
Positive percentage
|
Total score
|
Positive percentage
|
Total score
|
Nu (n = 7) | 6/7 (85.7%) | 3.29 ± 1.60 | 6/7 (85.7%) | 6.00 ± 2.77 | 4/7 (57.1%) | 3.29 ± 3.15 |
Nu + Cyto/Cyto (n = 41) | 40/41 (97.6%) | 4.00 ± 1.00 | 28/41 (68.3%) | 4.27 ± 3.11 | 41/41 (100%) | 6.32 ± 1.47 |
P-value | 0.147 | 0.227 | 0.349 | 0.118 | 0.000 | 0.015 |
Advanced reproductive age
| ||||||
Nu (n = 3) | 2/3 (66.7%) | 2.67 ± 2.31 | 2/3 (66.7%) | 4.67 ± 4.04 | 1/3 (33.3%) | 2.33 ± 4.04 |
Nu + Cyto/Cyto (n = 36) | 31/36 (86.1%) | 3.81 ± 1.65 | 22/36 (61.1%) | 4.14 ± 3.41 | 24/36 (66.7%) | 3.61 ± 2.98 |
P-value | 0.370 | 0.199 | 0.849 | 0.699 | 0.248 | 0.497 |