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Inflammation
Erschienen in: Inflammation 2/2020

01.04.2020 | Original Article

Differential Immunomodulatory Effect of Carbon Dots Influenced by the Type of Surface Passivation Agent

verfasst von: Furkan Ayaz, Melis Ozge Alas, Rukan Genc

Erschienen in: Inflammation | Ausgabe 2/2020

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Abstract

Carbon nanodots (CDs) are often synthesized from natural sources including honey, molasses, fruits, and foods, and plant extracts simply through caramelization. They have wide biological applications especially as drug delivery vehicles and bioimaging agent due to their small size and biocompatibility. This article details the synthesis of carbon dots from carob and its derivatives by surface passivation with polyethylene glycol (PEG), polyvinyl alcohol (PVA), and alginate (ALG). We investigated the immune response against CDs and evaluated the effect of surface passivation agents on their immunomodulatory functions. CDPVA had strong anti-inflammatory activities, whereas CDALG were pro-inflammatory. CDPEG had mild anti-inflammatory activities suggesting that these CDs can be used in the drug delivery studies as inert carriers. These results showed that depending on the type of activated groups dominated on the surface, CDs exerted differential effects on the inflammatory potential of the macrophages by changing the pro-inflammatory TNFα and IL6 production levels.
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Metadaten
Titel
Differential Immunomodulatory Effect of Carbon Dots Influenced by the Type of Surface Passivation Agent
verfasst von
Furkan Ayaz
Melis Ozge Alas
Rukan Genc
Publikationsdatum
01.04.2020
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 2/2020
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-019-01165-0

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