Background
Self-harm refers to any act of self-poisoning or self-injury irrespective of motivation [
1] and is a major public health concern [
2]. The aetiology is complex and self-harm is thought to arise through an interplay of genetic, biological, psychiatric, psychological, social and cultural factors [
3,
4]. Among many known risk factors for self-harm [
4], alcohol is estimated to be involved in 20% of observed global morbidity and mortality attributable to self-harm [
5]. In the UK more than half of individuals admitted to emergency departments following self-harm will have consumed alcohol alongside or in the hours preceding the episode [
6]. The status of alcohol as a major risk-factor for self-harm is well-recognised, with research activity often centred upon the role of alcohol-use disorders (AUDs; e.g., harmful use, dependence) [
7,
8] as diagnostic categories conferring an increased risk for self-harm and suicide (e.g., [
9,
10]). This has led to advances in our understanding of treatment and management of self-harm risk. However, we need to move beyond diagnostic categories of AUD to elucidate the alcohol-related mechanisms of self-harm enaction.
Although functions and motives for engaging in self-harm are varied and complex, for many people self-harm is a response to distressing internal emotional and cognitive states [
11‐
17]. Immediate experiences of pain and suffering may escalate when alcohol-induced cognitive and perceptual ‘myopia’ narrow attention to the proximal causes of distress whilst also limiting one’s capacity to identify adaptive coping strategies [
18]. To the extent that intoxication facilitates tunnel vision of one’s acute distress, self-harm enaction may increasingly be seen as the salient response [
19,
20]. Furthermore, when faced with heightened negative emotion, those with a behavioural propensity to engage in impulsive acts in order to reduce negative affect may also be at elevated risk of engaging in self-harm [
21‐
23]. Because any tendency to engage in rash actions in response to distress may be amplified following alcohol use, drinking episodes are likely to be a time of acute risk for self-harm enaction. Alcohol expectancies, representing beliefs about the effects of drinking alcohol, are proximal determinants of alcohol-related behaviour and outcomes, with belief in expected drinking outcomes directing future actions [
24,
25]. Alcohol expectancies therefore represent additional mechanisms of self-harm enaction if the anticipated outcomes of drinking trigger a transition from thinking about self-harm to self-harm acts [
19,
26,
27]. Expecting alcohol to bolster confidence (i.e. “liquid courage”) or facilitate risk-taking and aggressive behaviour, for example, may represent specific expected outcomes of drinking which override protective barriers such as fear and pain [
19,
26,
27].
Research on alcohol-related mechanisms that contribute to self-harm enaction will enhance understanding of the aetiology and management of self-harm. This focus is consistent with ideation-to-action approaches, which have improved our ability to distinguish between individuals who think about self-harm and those who act on their thoughts [
14,
28‐
31]. In particular, the Integrated Motivational-Volitional (IMV) model provides an explicit theoretical basis for integrating and sequencing factors and constructs associated with the emergence of thoughts of self-harm (i.e. ‘pre-motivational/motivational phase factors’) as well as those which govern the transition from thinking about self-harm to acting on those thoughts (i.e. ‘volitional phase factors’) [
30,
32]. In the present study, within the context of the IMV model, we investigated several alcohol factors, each representing a distinct possible path from self-harm thoughts to self-harm enaction. Given that alcohol use is highly prevalent within the general adult population of Scotland [
33], we investigated these factors in a community sample of adults with and without a history of thinking about or engaging in self-harm. Guided by the IMV model [
30] we expected drinking to intoxication, a tendency to engage in rash acts in order to alleviate negative affect when drinking, and alcohol expectancies, to act as volitional phase alcohol factors; thereby being particularly associated with self-harm acts. We therefore hypothesised that, in multivariate models, (i) those who have acted on their thoughts would differ significantly from those who have thoughts of self-harm (but have not acted upon these) and those with no history of thoughts or acts on each of these volitional phase alcohol factors. We also hypothesised that (ii) those who had thoughts about or engaged in self-harm would differ significantly from controls on a range of pre-motivational/motivational phase factors (perceived stress, social support, optimism and expectancies for negative mood regulation) but there would be no difference between those with thoughts of self-harm and those who have enacted self-harm.
Results
Of the 1546 participants in the study sample, 297 (19.21%) reported having thoughts of self-harm without acting upon them (the ‘ideation’ group), 346 (22.38%) reported acts of self-harm (the ‘enaction’ group) and 897 (58.02%) reported no history of thoughts or acts (the ‘control’ group). Six individuals did not respond to questions on self-harm and could not be allocated to a group. Those in the enaction group were more likely to be female (78%) than those in the ideation (68%; OR = 1.71, 95% CI = 1.20–2.43, p = 0.003) and control (68%; OR = 1.73, 95% CI = 1.29–2.32, p < 0.001) groups. Those in the enaction group also reported higher levels of depressive symptoms (Mean = 19.37, SE = 0.69) than those in the ideation group (Mean = 15.58, SE = 0.65; OR = 1.03, 95% CI = 1.01–1.04, p < 0.001), who in turn reported more depressive symptoms than those in the control group (Mean = 8.80, SE = 0.27; OR = 1.07, 95% CI = 1.06–1.09, p < 0.001). The enaction group tended to be younger (Mean = 29.03, SE = 0.57) than the ideation group (Mean = 34.12, SE = 0.75; OR = 0.97, 95% CI = 0.95–0.98, p < 0.001) who in turn were younger than the control group (Mean = 36.39, SE = 0.45; OR = 0.99, 95% CI = 0.98–1.00, p = 0.011).
Descriptive statistics for the pre-motivational and motivational phase factors as well as the volitional phase alcohol factors, by self-harm status, can be found in Table
1.
Table 1
Descriptive statistics (Mean, Standard Errora) for pre-motivational/motivational and volitional phase alcohol factors
Perceived stress | 5.03 (0.10) | 7.03 (0.19) | 7.92 (0.18) |
Support | 7.82 (0.05) | 7.05 (0.11) | 6.71 (0.10) |
NMR expectancies | 108.59 (0.53) | 95.85 (1.00) | 91.52 (1.08) |
Optimism | 3.77 (0.28) | 3.40 (0.05) | 3.21 (0.05) |
Volitional phase alcohol factors |
Heavy Drinking Frequency | 1.33 (0.03) | 1.27 (0.06) | 1.65 (0.05) |
Negative Urgency-A | 1.77 (0.02) | 1.93 (0.05) | 2.34 (0.04) |
CEOA: Sociability | 2.83 (0.02) | 2.94 (0.04) | 3.06 (0.03) |
CEOA: Tension Reduction | 2.52 (0.02) | 2.59 (0.04) | 2.59 (0.04) |
CEOA: Liquid Courage | 2.10 (0.03) | 2.26 (0.04) | 2.42 (0.04) |
CEOA: Cognitive & Behavioural Impairment | 2.44 (0.02) | 2.65 (0.04) | 2.73 (0.03) |
CEOA: Self-Perception | 1.63 (0.02) | 1.87 (0.04) | 2.00 (0.03) |
CEOA: Risk & Aggression | 1.81 (0.02) | 1.98 (0.04) | 2.14 (0.04) |
Alcohol Expectancy: Self-Harm | 1.33 (0.01) | 1.52 (0.03) | 1.68 (0.03) |
As expected univariate analyses (Table
2) indicated that those with a history of self-harm (those in ideation or enaction groups) reported significantly greater stress, lower perceived social support and more limited beliefs in their ability to address negative mood states compared to controls. Those with a history of self-harm enaction reported significantly lower optimism than those in the control group, but those in the control and ideation groups did not differ. Also as expected none of the pre-motivational/motivational phase factors differentiated between those in the ideation and enaction groups. In contrast the enaction and ideation groups did differ significantly from the control group and one another in the expected direction on several volitional phase alcohol factors (Table
3): the enaction group reported more frequent heavy drinking, higher alcohol-related negative urgency, as well as stronger expectancies that alcohol will lead to negative self-perceptions (Self-Perception) and markers of self-harm risk (Self-Harm alcohol expectancies). Expectancies that alcohol will lead to impaired functioning (Cognitive and Behavioural Impairment), enhance confidence and bravery (i.e. Liquid Courage) and risky and aggressive behaviour (Risk and Aggression) differed significantly across groups but not between the ideation and enaction groups.
Table 2
Univariate multinomial logistic regression analyses of the association between self-harm status and pre-motivational/motivational phase factors (adjusted for age, gender, depressive symptoms)
Pre-motivational/Motivational factors |
Perceived stress |
No self-harm enaction or ideation | Self-harm ideation | 1.10 | 1.04–1.17 | 0.002 |
No self-harm enaction or ideation | Self-harm enaction | 1.12 | 1.06–1.19 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.02 | 0.95–1.09 | 0.584 |
Support |
No self-harm enaction or ideation | Self-harm ideation | 0.90 | 0.82–0.98 | 0.019 |
No self-harm enaction or ideation | Self-harm enaction | 0.84 | 0.77–0.92 | < 0.001 |
Self-harm ideation | Self-harm enaction | 0.94 | 0.85–1.04 | 0.208 |
NMR expectancies |
No self-harm enaction or ideation | Self-harm ideation | 0.97 | 0.96–0.98 | < 0.001 |
No self-harm enaction or ideation | Self-harm enaction | 0.97 | 0.96–0.98 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.00 | 0.99–1.01 | 0.441 |
Optimism |
No self-harm enaction or ideation | Self-harm ideation | 0.83 | 0.69–1.00 | 0.053 |
No self-harm enaction or ideation | Self-harm enaction | 0.75 | 0.62–0.90 | 0.002 |
Self-harm ideation | Self-harm enaction | 0.90 | 0.73–1.10 | 0.299 |
Table 3
Univariate multinomial logistic regression analyses of the association between self-harm status and volitional phase alcohol factors (adjusted for age, gender, depressive symptoms)
Volitional phase alcohol factors |
Negative Urgency-A |
No self-harm enaction or ideation | Self-harm ideation | 1.11 | 0.91–1.35 | 0.314 |
No self-harm enaction or ideation | Self-harm enaction | 1.93 | 1.60–2.33 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.74 | 1.41–2.16 | < 0.001 |
Heavy Drinking Frequency |
No self-harm enaction or ideation | Self-harm ideation | 0.90 | 0.78–1.03 | 0.133 |
No self-harm enaction or ideation | Self-harm enaction | 1.31 | 1.13–1.51 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.46 | 1.24–1.72 | < 0.001 |
Alcohol expectancies |
CEOA: Sociability |
No self-harm enaction or ideation | Self-harm ideation | 1.08 | 0.87–1.32 | 0.494 |
No self-harm enaction or ideation | Self-harm enaction | 1.21 | 0.97–1.50 | 0.094 |
Self-harm ideation | Self-harm enaction | 1.12 | 0.87–1.44 | 0.371 |
CEOA: Tension Reduction |
No self-harm enaction or ideation | Self-harm ideation | 1.05 | 0.86–1.28 | 0.642 |
No self-harm enaction or ideation | Self-harm enaction | 1.05 | 0.86–1.29 | 0.637 |
Self-harm ideation | Self-harm enaction | 1.00 | 0.80–1.26 | 0.991 |
CEOA: Liquid Courage |
No self-harm enaction or ideation | Self-harm ideation | 1.14 | 0.94–1.38 | 0.186 |
No self-harm enaction or ideation | Self-harm enaction | 1.34 | 1.10–1.63 | 0.004 |
Self-harm ideation | Self-harm enaction | 1.18 | 0.94–1.47 | 0.151 |
CEOA: Cognitive & Behavioural Impairment |
No self-harm enaction or ideation | Self-harm ideation | 1.34 | 1.08–1.65 | 0.007 |
No self-harm enaction or ideation | Self-harm enaction | 1.49 | 1.19–1.85 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.11 | 0.86–1.43 | 0.415 |
CEOA: Self-Perception |
No self-harm enaction or ideation | Self-harm ideation | 1.52 | 1.20–1.92 | < 0.001 |
No self-harm enaction or ideation | Self-harm enaction | 2.02 | 1.60–2.55 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.33 | 1.03–1.72 | 0.03 |
CEOA: Risk & Aggression |
No self-harm enaction or ideation | Self-harm ideation | 1.22 | 0.98–1.51 | 0.074 |
No self-harm enaction or ideation | Self-harm enaction | 1.51 | 1.22–1.87 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.24 | 0.97–1.58 | 0.082 |
Alcohol Expectancy: Self-Harm |
No self-harm enaction or ideation | Self-harm ideation | 1.85 | 1.34–2.56 | < 0.001 |
No self-harm enaction or ideation | Self-harm enaction | 3.04 | 2.22–4.17 | < 0.001 |
Self-harm ideation | Self-harm enaction | 1.64 | 1.18–2.30 | 0.004 |
To determine their relative contribution to self-harm enaction the factors which distinguished between the ideation and enaction groups in the univariate analysis were entered into a multivariate multinomial logistic regression model: younger age (OR = 0.97, 95% CI = 0.96–0.99,
p < 0.001), female gender (OR = 1.81, 95% CI = 1.24–2.66,
p = 0.002), more frequent heavy drinking (OR = 1.32, 95% CI = 1.11–1.58,
p = 0.002) and alcohol-related negative urgency (OR = 1.47, 95% CI = 1.15–1.88,
p = 0.002) differentiated those in the ideation and enaction groups. Self-Perception alcohol expectancies (OR = 0.85, 95% CI = 0.58–1.23,
p = 0.382), Self-Harm alcohol expectancies (OR = 1.61, 95% CI = 1.00–2.59,
p = 0.051) and depressive symptoms (OR = 1.01, 95% CI = 1.00–1.03,
p = 0.056) did not differentiate those in the enaction and ideation groups in the multivariate model. Those in the enaction group also differed from those in the control group on each factor, apart from Self-Perception alcohol expectancies, and frequency of heavy drinking, following adjustment for multiple comparisons (see Additional file
1: Table S4).
Discussion
We have identified volitional phase alcohol factors associated with a history of self-harm enaction in a healthy community sample of the Scottish population. Increasing frequencies of drinking to intoxication and a greater tendency to engage in rash actions in order to reduce negative affect when drinking (i.e., alcohol-related negative urgency) were independently associated with self-harm enaction. Expecting alcohol to lead to outcomes consistent with increasing risk of self-harm followed a similar pattern of differentiating those in the ideation and enaction groups in univariate analyses only. Studied within an ideation-to-action framework [
30,
32] these relationships were specified a priori as potential paths towards self-harm enaction and were observed independently of depressive symptoms and demographic characteristics. This represents an important advance in current knowledge by focusing attention on several potential alcohol-related mechanisms of self-harm enaction rather than the presence or absence of underlying alcohol use disorder (e.g., [
9,
10]). Also as expected perceived stress, lower social support and more limited expectancies for negative mood regulation differed between those with a history of self-harm thoughts and acts, but did not differentiate those with a history of thinking about self-harm from those with a history of self-harm acts. Although we were surprised that more of the sample reported self-harm acts than thoughts of self-harm, this may simply reflect our self-harm classification, which combines suicidal and non-suicidal thoughts/acts and may be driven by a relatively high prevalence of non-suicidal self-harm in this population.
Whether the volitional phase alcohol factors described here have a causal role in self-harm enaction cannot be inferred from the cross-sectional study design and retrospective accounts of self-harm histories and alcohol-related thoughts and behaviours recorded in this study. However, we have identified plausible mechanisms by which volitional phase alcohol factors may lead to self-harm enaction and propose that these should be examined further in prospective studies to understand their role in any transition from thinking about self-harm to self-harm acts. These include intoxication exacerbating or leading to an escalation in emotional distress combined with a restricted ability to formulate adaptive coping strategies, a behavioural tendency to act rashly in response to negative affect when drinking, and behaving in accordance with one’s expectations that alcohol will lead to outcomes reflecting increasing risk for self-harm. Of particular concern is that features of these volitional phase alcohol factors may be self-reinforcing. To the extent that engaging in rash actions in response to distressing thoughts or emotions provides immediate short-term relief, and the outcomes of drinking are consistent with one’s expectancies, they may be reinforcing and establish or strengthen similar alcohol-related responses in future.
Because a sizeable minority of the Scottish adult population (35% men, 17% women) regularly drink at hazardous or harmful levels [
33], and lifetime prevalence of self-harm is also substantial [
53], the potential contribution of research on volitional phase alcohol factors to prevention and management of self-harm may be significant. Importantly, none of the volitional phase alcohol factors associated with self-harm enaction are a feature of clinical disorder and high or low levels of each may be considered a point on a continuum of normal functioning. Although standard assessments for alcohol use disorders which are recommended for use in routine practice may capture the frequency of intoxication (e.g., [
43,
54]), these are unlikely to include questions sensitive to capturing risk from other volitional phase alcohol factors. To the extent that further research provides robust evidence that volitional alcohol factors are associated with a transition from self-harm thoughts to self-harm acts, then assessment of risk for alcohol-related self-harm enaction may need to go beyond standard questions on quantity and frequency of alcohol use to assess behavioural tendencies and expectations when drinking alcohol.
Several additional comments on these volitional alcohol factors are needed. Two of the potential mechanisms of alcohol-related self-harm enaction we propose posit emotional distress as a contributing factor, yet negative affect was assessed only as part of the alcohol-related negative urgency measure. The extent to which emotional distress has a critical role to play in the relationship between intoxication and self-harm enaction therefore requires further investigation. Given limited prior empirical research on the role of alcohol expectancies as potential mechanisms of self-harm enaction, we investigated multiple common outcome expectancy domains. Only self-harm alcohol expectancies approached the conventional level of statistical significance (i.e.
p = .051) when considered alongside other volitional phase alcohol factors. While self-harm expectancies were based on a novel set of items, and have therefore not previously been psychometrically tested, we used a standard alcohol expectancy item format and based item content on contemporary theories of self-harm [
30,
49]. Furthermore, the ability of the novel self-harm alcohol expectancy measure to differentiate those with thoughts of self-harm from those who have acted on their thoughts in the univariate analyses suggests there is potential utility of this measure.
There are a number of limitations to this study. Counter-to-our hypothesis, optimism did not differ between those with and without a history of self-harm. We can provide no definitive explanation, but note that relevant studies reporting lower levels of optimism in those with a history of self-harm have tended to utilise more comprehensive multi-item assessments of optimism rather than the single item in the present study (e.g., [
31]). Further possible limitations stem from the use of a cross-sectional study design, and the measures of pre-motivational/motivational, volitional alcohol factors and self-harm used in this study. Specifically, some pre-motivational/motivational and volitional alcohol factors were assessed as relatively stable phenomena, while others assessed a recent specific period. In combination with the cross-sectional study design, it cannot be claimed that these measurements necessarily align or precede the development or transition of self-harm thoughts and acts. Furthermore, a number of alternative interpretations for these findings cannot be ruled out, including the possibility that volitional alcohol factors may reflect a maladaptive coping strategy which emerges after rather than prior to a self-harm act or that both self-harm and volitional alcohol factors are a consequence of underlying problems in self-regulation. Furthermore, the observed associations between volitional phase alcohol factors and self-harm enaction may also reflect historical or residual risk due to past alcohol-related behaviour and problems. Recent studies have sought to parse acute effects of alcohol on risk of suicide attempt from past behaviour utilising case-crossover designs, in which any alcohol-related features of an index suicide attempt are compared with a recent reference period from the same individual’s past (e.g., [
55]). Much can be gained from such designs, in which an individual or case also acts as a control for their own behaviour, but practical constraints mean there is often a focus on smaller samples of acutely suicidal patients. In contrast, the present research reports findings from a larger generally healthy population which are relevant to those across a spectrum of self-harm thoughts and acts. We would argue that a range of observational study designs is needed to provide converging evidence of the role of volitional alcohol factors.
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