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Skeletal Radiology

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22.09.2021 | Review Article

Diffuse vertebral marrow changes at MRI: Multiple myeloma or normal?

verfasst von: B. C. Vande Berg, T. Kirchgesner, S. Acid, J. Malghem, M. C. Vekemans, F. E. Lecouvet

Erschienen in: Skeletal Radiology | Ausgabe 1/2022

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Abstract

Five MRI patterns of marrow involvement (diffuse, focal, combined diffuse and focal, variegated, and normal) are observed in patients with a marrow proliferative disorder including MM. The wide range of marrow involvement patterns in monoclonal plasma cell proliferative disorders mirrors that of their natural histories that can vary from indolent to rapidly lethal. MRI of the axial bone marrow contributes to stage these disorders, but it should not be obtained for disease detection and characterization because of its limited specificity and sensitivity. At MRI, diffuse benign hematopoietic marrow hyperplasia and marrow heterogeneities in elderly patients mimic the diffuse and variegated patterns observed in MM patients. Careful analysis of fat- and fluid-sensitive MR images and quantitative marrow assessment by using MRI and FDG-PET can contribute in differentiating these changes from those associated with neoplastic marrow infiltration, with some residual overlapping findings.

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Titel: Diffuse vertebral marrow changes at MRI: Multiple myeloma or normal?
verfasst von: B. C. Vande Berg
T. Kirchgesner
S. Acid
J. Malghem
M. C. Vekemans
F. E. Lecouvet
Publikationsdatum: 22.09.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Skeletal Radiology / Ausgabe 1/2022
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-021-03886-6

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