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Erschienen in:
27.01.2022 | Diagnostic Neuroradiology
Diffusion and perfusion imaging biomarkers of H3 K27M mutation status in diffuse midline gliomas
Erschienen in: Neuroradiology | Ausgabe 8/2022
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Purpose
H3K27M-mutant diffuse midline gliomas (M-DMGs) exhibit a clinically aggressive course. We studied diffusion-weighted imaging (DWI) and perfusion (PWI) MRI features of DMG with the hypothesis that DWI-PWI metrics can serve as biomarkers for the prediction of the H3K27M mutation status in DMGs.
Methods
A retrospective review of the institutional database (imaging and histopathology) of patients with DMG (July 2016 to July 2020) was performed. Tumoral apparent diffusion coefficient (ADC) and peritumoral ADC (PT ADC) values and their normalized values (nADC and nPT ADC) were computed. Perfusion data were analyzed with manual arterial input function (AIF) and leakage correction (LC) Boxerman-Weiskoff models. Normalized maximum relative CBV (rCBV) was evaluated. Intergroup analysis of the imaging variables was done between M-DMGs and wild-type (WT-DMGs) groups.
Results
Ninety-four cases (M-DMGs-n = 48 (51%) and WT-DMGs-n = 46(49%)) were included. Significantly lower PT ADC (mutant—1.1 ± 0.33, WT—1.23 ± 0.34; P = 0.033) and nPT ADC (mutant—1.64 ± 0.48, WT—1.83 ± 0.54; P = 0.040) were noted in the M-DMGs. The rCBV (mutant—25.17 ± 27.76, WT—13.73 ± 14.83; P = 0.018) and nrCBV (mutant—3.44 ± 2.16, WT—2.39 ± 1.25; P = 0.049) were significantly higher in the M-DMGs group. Among thalamic DMGs, the min ADC, PT ADC, and nADC and nPT ADC were lower in M-DMGs while nrCBV (corrected and uncorrected) was significantly higher. Receiver operator characteristic curve analysis demonstrated that PT ADC (cut-off—1.245), nPT ADC (cut-off—1.853), and nrCBV (cut-off—1.83) were significant independent predictors of H3K27M mutational status in DMGs.
Conclusion
DWI and PWI features hold value in preoperative prediction of H3K27M-mutation status in DMGs.
