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European Spine Journal
Erschienen in:

03.08.2020 | Review Article

Diffusion tensor imaging with fiber tracking provides a valuable quantitative and clinical evaluation for compressed lumbosacral nerve roots: a systematic review and meta-analysis

verfasst von: Weishi Liang, Bo Han, Yong Hai, Peng Yin, Yuxiang Chen, Congying Zou

Erschienen in: European Spine Journal | Ausgabe 4/2021

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Abstract

Purpose

This study aimed to investigate the diagnostic value of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the diffusion tensor imaging (DTI) with fiber tracking in patients with compressed lumbosacral nerve roots.

Methods

A systematic literature search of databases (PubMed, Embase, Cochrane Library, and Web of Science) was carried out. FA values and ADC values were compared between compressed nerve roots and healthy controls. Pooled and subgroup analyses were performed using fixed or random-effect models based on I2 heterogeneity.

Results

A total of 262 patients from ten studies with 285 compressed lumbosacral nerve roots and 285 contralateral normal nerve roots were included in the meta-analysis. It was showed in pooled results that FA value was significantly reduced (SMD  − 3.03, 95% CI [ − 3.75 to  − 2.31], P < 0.001) and ADC value was significantly increased (SMD 2.07, 95% CI [0.92 to 3.22], P < 0.001) in the compressed nerve roots, compared with contralateral normal nerve roots. Subgroup analysis comparing the FA values and ADC values in different nerve root ranges (L2–S1, L4–S1, L5–S1, L5, S1) revealed the different ranges of nerve roots were possible sources of heterogeneity.

Conclusions

This study showed that FA value reduction and ADC value increase were valuable indicators of compressed lumbosacral nerve roots. These changes may be related to the neurological symptoms of patients. DTI with fiber tracking can directly visualize and accurately locate the compression zone of nerve roots to help make surgical treatment plans, is more advanced than conventional MRI.
Literatur
1.
2.
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S et al (2014) An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J 14:180–191CrossRef
3.
Brayda-Bruno M, Tibiletti M, Ito K, Fairbank J, Galbusera F, Zerbi A et al (2014) Advances in the diagnosis of degenerated lumbar discs and their possible clinical application. Eur Spine J 23:315–323CrossRef
4.
Oikawa Y, Eguchi Y, Inoue G, Yamauchi K, Orita S, Kamoda H (2015) Diffusion tensor imaging of lumbar spinal nerve in subjects with degenerative lumbar disorders. Magn Reson Imag 33:956–961CrossRef
5.
Liang KN, Feng PY, Feng XR, Cheng H (2019) Diffusion tensor imaging and fiber tractography reveal significant microstructural changes of cervical nerve roots in patients with cervical spondylotic radiculopathy. World Neurosurg 126:57–64CrossRef
6.
Cauley KA, Filippi CG (2013) Diffusion-tensor imaging of small nerve bundles: cranial nerves, peripheral nerves, distal spinal cord, and lumbar nerve roots–clinical applications. AJNR Am J Roentgenol 201:326–335CrossRef
7.
Takagi T, Nakamura M, Yamada M, Hikishima K, Momoshima S, Fujiyoshi K et al (2009) Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography. Neuroimage 44:884–892CrossRef
8.
Gasparotti R, Lodoli G, Meoded A, Carletti F, Garozzo D, Ferraresi S (2013) Feasibility of diffusion tensor tractography of brachial plexus injuries at 1.5 T. Invest Radiol 48:104–112CrossRef
9.
Hendrix P, Griessenauer CJ, Cohen-Adad J, Rajasekaran S, Cauley KA, Shoja MM et al (2015) Spinal diffusion tensor imaging: a comprehensive review with emphasis on spinal cord anatomy and clinical applications. Clin Anat 28:88–95CrossRef
10.
Zhang J, Zhang F, Xiao F, Xiong Z, Liu D, Hua T et al (2018) Quantitative evaluation of the compressed L5 and S1 nerve roots in unilateral lumbar disc herniation by using diffusion tensor imaging. Clin Neuroradiol 28:529–537CrossRef
11.
He A, Wang WZ, Qiao PF, Qiao GY, Cheng H, Feng PY (2018) Quantitative evaluation of compressed L4–5 and S1 nerve roots of lumbar disc herniation patients by diffusion tensor imaging and fiber tractography. World Neurosurg 115:45–52CrossRef
12.
Eguchi Y, Oikawa Y, Suzuki M, Orita S, Yamauchi K, Suzuki M et al (2016) Diffusion tensor imaging of radiculopathy in patients with lumbar disc herniation: preliminary results. Bone Joint J 98:387–394CrossRef
13.
Li CT, Wang QZ, Xiao WF, Hui YY, Zhao B (2014) 3.0T MRI tractography of lumbar nerve roots in disc herniation. Acta Radiol 55:969–975CrossRef
14.
Balbi V, Budzik JF, Duhamel A, Bera-Louville A, Thuc VL, Cotten A (2011) Tractography of lumbar nerve roots: initial results. Eur Radiol 21:1153–1159CrossRef
15.
Wu W, Liang J, Ru N, Zhou C, Chen J, Wu Y et al (2016) Microstructural changes in compressed nerve roots are consistent with clinical symptoms and symptom duration in patients with lumbar disc herniation. Spine 41:661–666CrossRef
16.
Wu W, Liang J, Chen Y, Chen A, Wu B, Yang Z (2016) Microstructural changes in compressed nerve roots treated by percutaneous transforaminal endoscopic discectomy in patients with lumbar disc herniation. Med 95:e5106CrossRef
17.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341CrossRef
18.
Wright JG, Swiontkowski MF, Heckman JD (2003) Introducing levels of evidence to the journal. J Bone Joint Surg Am 85:1–3CrossRef
19.
Wells G, Shea B, O’Connell D, Robertson J, Peterson J, Welch V et al (2000) The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
20.
Guan X, Fan G, Wu X, Gu G, Gu X, Zhang H et al (2015) Diffusion tensor imaging studies of cervical spondylotic myelopathy: a systemic review and meta-analysis. PLoS ONE 10:e0117707CrossRef
21.
Aoki Y, Inokuchi R, Gunshin M, Yahagi N, Suwa H (2012) Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. J Neurol Neurosurg Psychiatry 83:870–876CrossRef
22.
Shi Y, Zou Y, Feng Y, Dou W, Ding H, Wang C et al (2020) A quantitative and clinical evaluation of nerve roots in lumbosacral radiculopathy using diffusion tensor imaging. Jpn J Radiol 38:222–230CrossRef
23.
Li JQ, Cui H, Liu ZP, Sun YP, Zhang F, Sun YC et al (2019) Utility of diffusion tensor imaging for guiding the treatment of lumbar disc herniation by percutaneous transforaminal endoscopic discectomy. Sci Rep 9:187532019
24.
Wang XD, Wang HL, Sun C, Zhou SY, Meng T, Lv FZ et al (2019) Analysis of radiological parameters associated with decreased fractional anisotropy values on diffusion tensor imaging in patients with lumbar spinal stenosis. Eur Spine J 28:1397–1405CrossRef
25.
Li XF, Yang Y, Lin CB, Xie FR, Liang WG (2016) Assessment of the diagnostic value of diffusion tensor imaging in patients with spinal cord compression: a meta-analysis. Braz J Med Biol Res 49:e4769CrossRef
26.
Li JF, Wang YH, Wang YY, Lv Y, Ma L (2016) Study on lumbosacral nerve root compression using DTI. Biomed Rep 5:353–356CrossRef
27.
Eguchi Y, Ohtori S, Orita S, Kamoda H, Arai G, Ishikawa T et al (2011) Quantitative evaluation and visualization of lumbar foraminal nerve root entrapment by using diffusion tensor imaging: preliminary results. AJNR Am J Neuroradiol 32:1824–1829CrossRef
28.
Toh E, Mochida J (1997) Histologic analysis of the lumbosacral nerve roots after compression in young and aged rabbits. Spine 22:721–726CrossRef
29.
Suzuki K, Takatsu T, Inoue H, Teramoto T, Ishida Y, Ohmori K (1992) Redundant nerve roots of the cauda equina caused by lumbar spinal canal stenosis. Spine 17:1337–1342CrossRef
30.
Wu W, Niu Y, Kong X, Liu D, Long X, Shu S et al (2018) Application of diffusion tensor imaging in quantitatively monitoring chronic constriction injury of rabbit sciatic nerves: correlation with histological and functional changes. Br J Radiol 91:20170414PubMed
31.
Lehmann HC, Zhang J, Mori S, Sheikh KA (2010) Diffusion tensor imaging to assess axonal regeneration in peripheral nerves. Exp Neurol 223:238–244CrossRef
32.
Wu W, Liang J, Chen Y, Chen A, Wu Y, Yang Z (2017) Microstructural changes are coincident with the improvement of clinical symptoms in surgically treated compressed nerve roots. Sci Rep 7:44678CrossRef
33.
Eguchi Y, Ohtori S, Suzuki M, Oikawa Y, Yamanaka H, Tamai H et al (2016) Discrimination between lumbar intraspinal stenosis and foraminal stenosis using diffusion tensor imaging parameters: preliminary results. Asian Spine J 10:327–334CrossRef
Metadaten
Titel
Diffusion tensor imaging with fiber tracking provides a valuable quantitative and clinical evaluation for compressed lumbosacral nerve roots: a systematic review and meta-analysis
verfasst von
Weishi Liang
Bo Han
Yong Hai
Peng Yin
Yuxiang Chen
Congying Zou
Publikationsdatum
03.08.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Spine Journal / Ausgabe 4/2021
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-020-06556-8

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