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Magnetic Resonance Materials in Physics, Biology and Medicine

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30.07.2020 | Research Article

Diffusion-weighted imaging in the assessment of renal function in patients with diabetes mellitus type 2

verfasst von: Tijana Mrđanin, Olivera Nikolić, Una Molnar, Milena Mitrović, Viktor Till

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 2/2021

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Abstract

Objective

Investigation of functional magnetic resonance (MR) imaging role in early diagnosis of diabetic nephropathy (DN) in patients with diabetes mellitus (DM) type 2, by quantification of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values.

Material and methods

10 healthy volunteers and 91 DM type 2 patients were scanned using diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) sequences. Patients were divided into four groups based on the estimated glomerular filtration value (eGFR). ADC and FA values, calculated in six regions of interest in each kidney (cortex and medulla), were compared to eGFR and laboratory parameters of renal function.

Results

ADC values of DM patients were higher in the cortex than in the medulla (p < 0.01), while FA values were higher in the medulla (p = 0.284). Creatinine, cystatin C negatively correlated with ADC (cortex, medulla, parenchyma). Medullary FA were lower in DM patients and positively correlated with the eGFR (p = 0.049). Tractography showed disturbed structure in patients with impaired renal function.

Discussion

Medullary FA value is a more sensitive parameter than parenchymal ADC in the early detection of renal damage in DM patients. ADC and FA values are significant in the diagnosis of DN; further research is needed for the update and refinement of the established recommendations.

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Titel: Diffusion-weighted imaging in the assessment of renal function in patients with diabetes mellitus type 2
verfasst von: Tijana Mrđanin
Olivera Nikolić
Una Molnar
Milena Mitrović
Viktor Till
Publikationsdatum: 30.07.2020
Verlag: Springer International Publishing
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 2/2021
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-020-00869-x

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Diffusion-weighted imaging in the assessment of renal function in patients with diabetes mellitus type 2

Abstract

Objective

Material and methods

Results

Discussion

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Springer Medizin

Abstract

Objective

Material and methods

Results

Discussion

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