Skip to main content
main-content

01.08.2015 | Original Article | Ausgabe 2/2015

Virchows Archiv 2/2015

Digital slide viewing for primary reporting in gastrointestinal pathology: a validation study

Zeitschrift:
Virchows Archiv > Ausgabe 2/2015
Autoren:
Maurice B. Loughrey, Paul J. Kelly, Oisin P. Houghton, Helen G. Coleman, Joseph P. Houghton, Anne Carson, Manuel Salto-Tellez, Peter W. Hamilton

Abstract

Despite the increasing availability of digital slide viewing, and numerous advantages associated with its application, a lack of quality validation studies is amongst the reasons for poor uptake in routine practice. This study evaluated primary digital pathology reporting in the setting of routine subspecialist gastrointestinal pathology, commonplace in most tissue pathology laboratories and representing one of the highest volume specialties in most laboratories. Individual digital and glass slide diagnoses were compared amongst three pathologists reporting in a gastrointestinal subspecialty team, in a prospective series of 100 consecutive diagnostic cases from routine practice in a large teaching hospital laboratory. The study included a washout period of at least 6 months. Discordant diagnoses were classified, and the study evaluated against recent College of American Pathologists (CAP) recommendations for evaluating digital pathology systems for diagnostic use. The study design met all 12 of the CAP recommendations. The 100 study cases generated 300 pairs of diagnoses, comprising 100 glass slide diagnoses and 100 digital diagnoses from each of the three study pathologists. 286 of 300 pairs of diagnoses were concordant, representing intraobserver concordance of 95.3 %, broadly comparable to rates previously published in this field. In ten of the 14 discordant pairs, the glass slide diagnosis was favoured; in four cases, the digital diagnosis was favoured, but importantly, the 14 discordant intraobserver diagnoses were considered to be of minor clinical significance. Interobserver, or viewing modality independent, concordance was found in 94 of the total of 100 study cases, providing a comparable baseline discordance rate expected in any second viewing of pathology material. These overall results support the safe use of digital pathology in primary diagnostic reporting in this setting.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 2/2015

Virchows Archiv 2/2015 Zur Ausgabe

Neu im Fachgebiet Pathologie

01.08.2019 | Originalien | Ausgabe 4/2019

Cocainkonsumintensität als Ursache erworbener Herzerkrankungen?

Korrelationen bei cocainassoziierten Drogentodesfällen

26.06.2019 | Nebennierentumoren | CME | Ausgabe 4/2019

CME: Aktualisierter Überblick zu Tumoren der Nebenniere

Aktualisierter Überblick

26.06.2019 | Schwerpunkt: Sarkome | Ausgabe 4/2019

Diagnostik und Management von Gefäßmalformationen

Interdisziplinäres Teamwork gefragt

26.06.2019 | Schwerpunkt: Sarkome | Ausgabe 4/2019

Systemische Therapie von Sarkomen

Neue Biomarker und Therapiestrategien