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European Radiology
Erschienen in:

25.07.2024 | Magnetic Resonance

Dilated lenticulostriate artery on whole-brain vessel wall imaging differentiates pathogenesis and predicts clinical outcomes in single subcortical infarction

verfasst von: Jin Li, Junxia Niu, Weimin Zheng, Yueyan Bian, Fang Wu, Xiuqin Jia, Zhaoyang Fan, Xihai Zhao, Qi Yang

Erschienen in: European Radiology | Ausgabe 2/2025

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Abstract

Objectives

This study aimed to investigate the dilation of lenticulostriate artery (LSA) identified by whole-brain vessel wall imaging (WB-VWI) in differentiating the etiologic subtypes of single subcortical infarction (SSI) and to determine whether the appearance of dilated LSA was associated with 90-day clinical outcomes in parental atherosclerotic disease (PAD)-related SSI.

Methods

Patients with acute SSI were prospectively enrolled and categorized into PAD-related SSI and cerebral small-vessel disease (CSVD)-related SSI groups. The imaging features of LSA morphology (branches, length, dilation, and tortuosity), plaques (burden, remodeling index, enhancement degree, and hyperintense plaque), and CSVD (white matter hyperintensity, lacunes, cerebral microbleed, and enlarged perivascular space) were evaluated. The logistic regression was performed to determine the association of dilated LSA with PAD-related SSI and 90-day clinical outcomes.

Results

In total, 131 patients (mean age, 52.2 ± 13.2 years; 99 men) were included. The multivariate logistic regression analysis revealed that the presence of dilated LSAs (odds ratio (OR), 7.40; 95% confidence interval (CI): 1.88–29.17; p = 0.004)) was significantly associated with PAD-related SSI. Moreover, after adjusting for confounding factors, the association of poor outcomes with the total length of LSAs (OR, 0.94; 95% CI: 0.90–0.99; p = 0.011), dilated LSAs (OR, 0.001; 95% CI: 0.0001–0.08; p = 0.002), and plaque burden (OR, 1.35; 95% CI: 1.11–1.63; p = 0.002) remained statistically significant.

Conclusion

The dilation of LSA visualized on WB-VWI could differentiate various subtypes of SSI within LSA territory and was a prognostic imaging marker for 90-day clinical outcomes for PAD-related SSI.

Clinical relevance statement

Evaluation of LSA morphology based on WB-VWI can differentiate the pathogenesis and predict clinical outcomes in SSI, providing crucial insights into the etiologic mechanisms, risk stratification, and tailored therapies for these patients.

Key Points

  • The prognosis of SSIs within lenticulostriate territory depend on the etiology of the disease.
  • LSA dilation on WB-VWI was associated with parental atherosclerosis and better 90-day outcomes.
  • Accurately identifying the etiology of SSIs in lenticulostriate territory assists in treatment decision-making.
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Metadaten
Titel
Dilated lenticulostriate artery on whole-brain vessel wall imaging differentiates pathogenesis and predicts clinical outcomes in single subcortical infarction
verfasst von
Jin Li
Junxia Niu
Weimin Zheng
Yueyan Bian
Fang Wu
Xiuqin Jia
Zhaoyang Fan
Xihai Zhao
Qi Yang
Publikationsdatum
25.07.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2025
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-024-10971-6

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