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01.06.2005 | Poster Presentation

Discovering genetic profiles by array-CGH in familial breast tumors

verfasst von: PM Nederlof, E van Beers, S Joosse, FBL Hogervorst, LFA Wessels, P Devilee, C Cornelisse, R Oldenburg, S Verhoef, LJ van 't Veer

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

We have recently shown that BRCA1 breast tumors can be identified on the basis of their somatic genetic aberrations detected by comparative genomic hybridization (CGH) profiles with high performance (sensitivity: 96%) [1]. Also, BRCA2 show some specific alterations, but are more similar to sporadic breast tumors [2]. These results illustrate that breast tumors from different genetic backgrounds (BRCA1 and BRCA2) develop different genomic instabilities, and therefore genomic profiles. We hypothesize that this may also be true for BRCAx (BRCA3, BRCA 4, etc.) tumors. We therefore applied CGH to familial breast cancer cases from families without BRCA1/2 mutations. …

Wessels LF, et al: Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res. 2002, 62: 7110-7117.PubMed

van Beers EH, et al: CGH profiles in human BRCA1 and BRCA2 breast tumors highlight differential sets of genomic aberrations. Cancer Res. 2005, 65: 822-827.PubMed

Jong K, et al: Breakpoint identification and smoothing of array comparative genomic hybridization data. Bioinformatics. 2004, 20: 3636-3637.CrossRefPubMed

Chung YJ, et al: A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res. 2004, 14: 188-196. 10.1101/gr.1878804.CrossRefPubMedPubMedCentral

Titel: Discovering genetic profiles by array-CGH in familial breast tumors
verfasst von: PM Nederlof
E van Beers
S Joosse
FBL Hogervorst
LFA Wessels
P Devilee
C Cornelisse
R Oldenburg
S Verhoef
LJ van 't Veer
Publikationsdatum: 01.06.2005
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1166

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Discovering genetic profiles by array-CGH in familial breast tumors

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

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