Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy
- 26.01.2017
- Original Article
Erschienen in:
- Verfasst von
- Emily Cox-Martin
- Lisa H. Trahan
- Matthew G. Cox
- Patrick M. Dougherty
- Emily A. Lai
- Diane M. Novy
- Erschienen in
- Supportive Care in Cancer | Ausgabe 6/2017
Abstract
Purpose
Chemotherapy-induced peripheral neuropathy (CIPN) and obesity are prevalent in cancer survivors and decrease quality of life; however, the impact of the co-occurrence of these conditions has garnered little attention. This study investigated differences between obese and non-obese cancer survivors with CIPN and predictors of symptom burden and pain.
Methods
Patients with CIPN were administered the MD Anderson Symptom Inventory and a modified version of pain descriptors from the McGill Pain Inventory. Independent t tests assessed group differences between obese and non-obese survivors, and linear regression analyses explored predictors of patient outcomes.
Results
Results indicated a significant difference in symptom severity scores for obese (M = 32.89, SD = 25.53) versus non-obese (M = 19.35, SD = 16.08) patients (t(37.86) = −2.49, p = .02). Significant differences were also found for a total number of pain descriptors endorsed by obese (M = 4.21, SD = 3.45) versus non-obese (M = 2.42, SD = 2.69) participants (t(74) = −2.53, p = .01). Obesity was a significant predictor of symptom severity and total pain descriptors endorsed. Other significant predictors included age and months since treatment.
Conclusions
Cancer survivors with CIPN and co-occurring obesity may be more at risk for decreased quality of life through increased symptom severity and pain compared to non-obese survivors. This paper identified risk factors, including obesity, age, and months since treatment, that can be clinically identified for monitoring distress in CIPN patients. Future research should focus on the longitudinal relationship between obesity and CIPN, and robust interventions to address the multifaceted issues faced by cancer survivors.
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- Titel
- Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy
- Verfasst von
-
Emily Cox-Martin
Lisa H. Trahan
Matthew G. Cox
Patrick M. Dougherty
Emily A. Lai
Diane M. Novy
- Publikationsdatum
- 26.01.2017
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Supportive Care in Cancer / Ausgabe 6/2017
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339 - DOI
- https://doi.org/10.1007/s00520-017-3571-5
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