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Archives of Osteoporosis

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01.12.2021 | Original Article

Disease progression associated with low bone mass in axial spondyloarthropathy patients

verfasst von: De Hao Liu, Juan Chen, Xiong Jie Zhuang, li Chun Chen

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2021

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Abstract

Summary

Through statistical analysis, we have found that inflammation and low femoral and lumbar spine BMD were strongly correlated with a high SIJ CT grade, and inflammation, low vitamin D levels, and a longer disease course within a certain time range influenced bone loss in axSpA.

Purpose

We investigated the relationship between bone mineral density (BMD), vitamin D, and computed tomography (CT)–based progression of disease grades of the sacroiliac joint (SIJ), and sought to identify parameters predicting low BMD in patients with axial spondyloarthropathy (axSpA).

Methods

We collected the ankylosis spondylitis disease activity score (ASDAS), the course of the disease, HLA-B27 status, and vitamin D and C-reactive protein (CRP) levels of 98 axSpA patients. Lumbar spine and femoral BMD were assessed by dual-energy X-ray (DXA), and SIJ grade was determined by CT.

Results

The axSpA patients (71 men, 27 women) with a mean age of 31.9 years (range 18–57 years) and body mass index 21.8 kg/m² (range 15.6–30.6 kg/m²), with disease duration 4.5 years (range 0.3–30 years) were included. A longer disease course, higher CRP level, and lower femoral and lumbar spine BMD were independently related to a higher CT grade. Older age, longer disease course, elevated CRP, and high SIJ CT grade were independently related to lower BMD (femur and/or lumbar spine L1–L4 T scores ≤ −1). Older age, elevated CRP, low vitamin D levels, and high CT grade were independently associated with low femur and lumbar spine BMD. However, a longer disease course was independently related to low femur BMD, but not low lumbar spine BMD.

Conclusions

Thus, inflammation and low femoral and lumbar spine BMD were strongly correlated with a high SIJ CT grade, and inflammation, low vitamin D levels, and a longer disease course within a certain time range influenced bone loss in axSpA.

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Titel: Disease progression associated with low bone mass in axial spondyloarthropathy patients
verfasst von: De Hao Liu
Juan Chen
Xiong Jie Zhuang
li Chun Chen
Publikationsdatum: 01.12.2021
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2021
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-00928-3

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Disease progression associated with low bone mass in axial spondyloarthropathy patients

Abstract

Summary

Purpose

Methods

Results

Conclusions

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Abstract

Summary

Purpose

Methods

Results

Conclusions

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