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01.11.2018 | Women’s Health (M Wood, Section Editor) | Ausgabe 11/2018

Disparities in Cardiac Care of Women: Current Data and Possible Solutions

Zeitschrift:: Current Treatment Options in Cardiovascular Medicine > Ausgabe 11/2018

Autoren:: MD, Pharm D Rosalyn O. Adigun, MD Amber N. Boler, MD Rekha Mankad

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Wichtige Hinweise

Rosalyn O. Adigun and Amber N. Boler contributed equally to this work.

This article is part of the Topical Collection on Women’s Health

Abstract

Purpose of review

Cardiovascular disease remains the leading cause of death in women. The goal of this review is to address known disparities in cardiovascular care with regard to diagnosis and treatment of heart disease in women.

Recent findings

Gender-specific differences in regard to the incidence, treatment, and outcomes of common cardiovascular pathology are increasingly recognized. Particular attention to ischemic heart disease, arrhythmia, congestive heart failure, and structural heart disease are reviewed in this article. There is a clear racial and ethnic discrepancy among women which is particularly concerning with a progressively diverse patient population. Medical and surgical treatment differences between men and women must be addressed by providers in order to optimize long-term outcomes among all patients.

Summary

Understanding the unique cardiovascular risk profile and barriers to optimal treatment outcomes in women is imperative to eliminate the current disparities in cardiovascular disease.

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Thompson LE, Daugherty SL. Gender disparities in cardiovascular disease prevention. Heart. 2017;103(7):479–80. https://doi.org/10.1136/heartjnl-2016-310788. CrossRefPubMed

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67–e492. https://doi.org/10.1161/CIR.0000000000000558. CrossRef

Jarvie JL, Foody JM. Recognizing and improving health care disparities in the prevention of cardiovascular disease in women. Curr Cardiol Rep. 2010;12(6):488–96. https://doi.org/10.1007/s11886-010-0135-4. CrossRefPubMed

Mosca L, Ouyang P, Hubel CA, Reynolds HR, Allison MA. Go red for women strategically focused research network centers. Circulation. 2017;135(6):609–11. https://doi.org/10.1161/CIRCULATIONAHA.116.025955. CrossRefPubMed

Shaw LJ, Bugiardini R, Merz CN. Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol. 2009;54(17):1561–75. CrossRef

Mosca L, Barrett-Connor E, Wenger NK. Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes. Circulation. 2011;124(19):2145–54. https://doi.org/10.1161/CIRCULATIONAHA.110.968792. CrossRef

Vaccarino V. Ischemic heart disease in women: many questions, few facts. Circ Cardiovasc Qual Outcomes. 2010;3(2):111–5. https://doi.org/10.1161/CIRCOUTCOMES.109.925313. CrossRefPubMedPubMedCentral

Sharaf BL, Pepine CJ, Kerensky RA, Reis SE, Reichek N, Rogers WJ, et al. Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). Am J Cardiol. 2001;87(8):937–41; A3. https://doi.org/10.1016/S0002-9149(01)01424-2. CrossRef

Crea F, Camici PG, Bairey Merz CN. Coronary microvascular dysfunction: an update. Eur Heart J. 2014;35(17):1101–11. https://doi.org/10.1093/eurheartj/eht513. CrossRefPubMed

10.

Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study. Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol. 2006;47(3 Suppl):S21–9.

11.

•• Garcia M, Mulvagh SL, Merz CN, Buring JE, Manson JE. Cardiovascular disease in women: clinical perspectives. Circ Res. 2016;118(8):1273–93. https://doi.org/10.1016/j.ijfoodmicro.2018.08.022. Article discusses the increasing prevelance and severity of traditional cardiovascular risk factors in women while detailing the female-specific risk factors that contribute to gender-based differences in treatment and outcomes. CrossRefPubMedPubMedCentral

12.

Lisabeth LD, Beiser AS, Brown DL, Murabito JM, Kelly-Hayes M, Wolf PA. Age at natural menopause and risk of ischemic stroke: the Framingham heart study. Stroke. 2009;40(4):1044–9. https://doi.org/10.1161/STROKEAHA.108.542993. CrossRefPubMedPubMedCentral

13.

Garcia M, Miller VM, Gulati M, Hayes SN, Manson JE, Wenger NK, et al. Focused cardiovascular care for women: the need and role in clinical practice. Mayo Clin Proc. 2016;91(2):226–40. https://doi.org/10.1016/j.mayocp.2015.11.001. CrossRefPubMed

14.

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146–603. https://doi.org/10.1161/CIR.0000000000000485. CrossRefPubMedPubMedCentral

15.

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics—2016 update. A Report From the American Heart Association 2015, https://doi.org/10.11646/zootaxa.4052.4.2.

16.

Pemu PI, Ofili E. Hypertension in women: part I. J Clin Hypertens (Greenwich, Conn). 2008;10(5):406–10. https://doi.org/10.1038/oby.2011.370. CrossRef

17.

Virani SS, Woodard LD, Ramsey DJ, Urech TH, Akeroyd JM, Shah T, et al. Gender disparities in evidence-based statin therapy in patients with cardiovascular disease. Am J Cardiol. 2015;115(1):21–6. https://doi.org/10.1016/j.amjcard.2014.09.041. CrossRefPubMed

18.

Bello N, Mosca L. Epidemiology of coronary heart disease in women. Prog Cardiovasc Dis. 2004;46(4):287–95. https://doi.org/10.1016/j.pcad.2003.08.001. CrossRefPubMed

19.

Howard G, Safford MM, Moy CS, Howard VJ, Kleindorfer DO, Unverzagt FW, et al. Racial differences in the incidence of cardiovascular risk factors in older black and white adults. J Am Geriatr Soc. 2017;65(1):83–90. https://doi.org/10.1111/jgs.14472. CrossRefPubMed

20.

Kohli P, Gulati M. Exercise stress testing in women: going back to the basics. Circulation. 2010;122(24):2570–80. https://doi.org/10.1161/CIRCULATIONAHA.109.914754. CrossRefPubMed

21.

Mieres JH, Gulati M, Bairey Merz N, Berman DS, Gerber TC, Hayes SN, et al. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association. Circulation. 2014;130(4):350–79. https://doi.org/10.1161/CIR.0000000000000061. CrossRefPubMed

22.

Gulati M, Black HR, Shaw LJ, Arnsdorf MF, Merz CN, Lauer MS, et al. The prognostic value of a nomogram for exercise capacity in women. N Engl J Med. 2005;353(5):468–75. https://doi.org/10.1056/NEJMoa044154. CrossRefPubMed

23.

Alexander KP, Shaw LJ, Shaw LK, Delong ER, Mark DB, Peterson ED. Value of exercise treadmill testing in women. J Am Coll Cardiol. 1998;32(6):1657–64. CrossRef

24.

McCully RB, Roger VL, Mahoney DW, Karon BL, Oh JK, Miller FA Jr, et al. Outcome after normal exercise echocardiography and predictors of subsequent cardiac events: follow-up of 1,325 patients. J Am Coll Cardiol. 1998;31(1):144–9. CrossRef

25.

Kim C, Kwok YS, Heagerty P, Redberg R. Pharmacologic stress testing for coronary disease diagnosis: a meta-analysis. Am Heart J. 2001;142(6):934–44. https://doi.org/10.1067/mhj.2001.119761. CrossRefPubMed

26.

Dionisopoulos PN, Collins JD, Smart SC, Knickelbine TA, Sagar KB. The value of dobutamine stress echocardiography for the detection of coronary artery disease in women. J Am Soc Echocardiogr. 1997;10(8):811–7. CrossRef

27.

Metz LD, Beattie M, Hom R, Redberg RF, Grady D, Fleischmann KE. The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography: a meta-analysis. J Am Coll Cardiol. 2007;49(2):227–37. CrossRef

28.

Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, et al. Age- and gender-specific differences in the prognostic value of CT coronary angiography. Heart. 2012;98(3):232–7. CrossRef

29.

Lin F, Chinnaiyan K, Dunning AM, Shaw LJ, Achenbach S, Al-Mallah M, et al. Gender differences in all-cause death by extent and severity of coronary artery disease by cardiac computed tomographic angiography: a matched analysis of the confirm registry. J Am Coll Cardiol. 2011;57(14 Supplement):E773. CrossRef

30.

Blomkalns AL, Chen AY, Hochman JS, Peterson ED, Trynosky K, Diercks DB, et al. Gender disparities in the diagnosis and treatment of non–ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol. 2005;45(6):832–7. CrossRef

31.

Alfredsson J, Stenestrand U, Wallentin L, Swahn E. Gender differences in management and outcome in non-ST-elevation acute coronary syndrome. Heart. 2007;93(11):1357–62. https://doi.org/10.1136/hrt.2006.102012. CrossRefPubMed

32.

Daly C, Clemens F, Lopez Sendon JL, Tavazzi L, Boersma E, Danchin N, et al. Gender differences in the management and clinical outcome of stable angina. Circulation. 2006;113(4):490–8. https://doi.org/10.1161/CIRCULATIONAHA.105.561647. CrossRefPubMed

33.

D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, et al. Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study. Circulation. 2015;131(15):1324–32. https://doi.org/10.1161/CIRCULATIONAHA.114.012293. CrossRefPubMedPubMedCentral

34.

Agewall S, Beltrame JF, Reynolds HR, Niessner A, Rosano G, Caforio AL, et al. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2016;38(3):143–53.

35.••

Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and non-obstructive coronary arteries (MINOCA). Circulation. 2015:CIRCULATIONAHA. 114.011201. https://doi.org/10.1097/MCA.0000000000000652. Extensive systemic review detailing the prevalence, underlying etiology, and outcomes related to myocardial infarction with non-obstructive coronary arteries which may be over-represented in women CrossRef

36.

Grodzinsky A, Arnold SV, Gosch K, Spertus JA, Foody JM, Beltrame J, et al. Angina frequency after acute myocardial infarction in patients without obstructive coronary artery disease. European Heart Journal–Quality of Care and Clinical Outcomes. 2015;1(2):92–9. https://doi.org/10.1093/ehjqcco/qcv014. CrossRefPubMed

37.

Kang WY, Jeong MH, Ahn YK, Kim JH, Chae SC, Kim YJ, et al. Are patients with angiographically near-normal coronary arteries who present as acute myocardial infarction actually safe? Int J Cardiol. 2011;146(2):207–12. https://doi.org/10.1016/j.ijcard.2009.07.001. CrossRefPubMed

38.

Epps KC, Holper EM, Selzer F, Vlachos HA, Gualano SK, Abbott JD, et al. Sex differences in outcomes following percutaneous coronary intervention according to age. Circ Cardiovasc Qual Outcomes. 2016;9(2 suppl 1):S16–25. CrossRef

39.

Alfonso F, Hernandez R, Banuelos C, Fernández-Ortíz A, Escaned J, Sabaté M, et al. Initial results and long-term clinical and angiographic outcome of coronary stenting in women. Am J Cardiol. 2000;86(12):1380–3, A5. https://doi.org/10.1016/S0002-9149(00)01249-2. CrossRefPubMed

40.

Anderson ML, Peterson ED, Brennan JM, Rao SV, Dai D, Anstrom KJ, et al. Short-and long-term outcomes of coronary stenting in women versus MenClinical perspective: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid Services Cohort. Circulation. 2012;126(18):2190–9. https://doi.org/10.1161/CIRCULATIONAHA.112.111369. CrossRefPubMed

41.

Sabbag A, Matetzky S, Porter A, Iakobishvili Z, Moriel M, Zwas D, et al. Sex differences in the management and 5-year outcome of young patients (<55 Years) with acute coronary syndromes. Am J Med. 2017;130(11):1324.e15–22. https://doi.org/10.1097/SCS.0000000000004587. CrossRef

42.

Dunlay SM, Pack QR, Thomas RJ, Killian JM, Roger VL. Participation in cardiac rehabilitation, readmissions, and death after acute myocardial infarction. Am J Med. 2014;127(6):538–46. https://doi.org/10.1016/j.amjmed.2014.02.008. CrossRefPubMedPubMedCentral

43.

Rodriguez F, Foody JM, Wang Y, Lopez L. Young Hispanic women experience higher in-hospital mortality following an acute myocardial infarction. J Am Heart Assoc. 2015;4(9):e002089. https://doi.org/10.1161/JAHA.115.002089. CrossRefPubMedPubMedCentral

44.

Zhang ZM, Rautaharju PM, Prineas RJ, Rodriguez CJ, Loehr L, Rosamond WD, et al. Race and sex differences in the incidence and prognostic significance of silent myocardial infarction in the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2016;133(22):2141–8. https://doi.org/10.1161/CIRCULATIONAHA.115.021177. CrossRefPubMedPubMedCentral

45.

Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study. Circulation. 2014;129(8):837–47. https://doi.org/10.1161/CIRCULATIONAHA.113.005119. CrossRef

46.

Ko D, Rahman F, Martins MAP, Hylek EM, Ellinor PT, Schnabel RB, et al. Atrial fibrillation in women: treatment. Nat Rev Cardiol. 2017;14(2):113–24. https://doi.org/10.1038/nrcardio.2016.171. CrossRefPubMed

47.

January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):e199–267. https://doi.org/10.1161/CIR.0000000000000041. CrossRefPubMedPubMedCentral

48.

• Bhave PD, Lu X, Girotra S, Kamel H, Vaughan Sarrazin MS. Race- and sex-related differences in care for patients newly diagnosed with atrial fibrillation. Heart Rhythm. 2015;12(7):1406–12. https://doi.org/10.1016/j.jhep.2018.06.012. This study encompasses a large cohort of patients with a thorough discussion of race- and sex-based differences in the current pattern of treatment and care of atrial fibrillation. The majority of differences remained significant after controlling for confounders CrossRefPubMedPubMedCentral

49.

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016;133(4):e38–360. https://doi.org/10.1161/CIR.0000000000000350. CrossRef

50.

Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7(10):915–26. https://doi.org/10.1016/S1474-4422(08)70193-5. CrossRefPubMedPubMedCentral

51.

Fonarow GC, Reeves MJ, Zhao X, Olson DM, Smith EE, Saver JL, et al. Age-related differences in characteristics, performance measures, treatment trends, and outcomes in patients with ischemic stroke. Circulation. 2010;121(7):879–91. https://doi.org/10.1161/CIRCULATIONAHA.109.892497. CrossRefPubMed

52.

Friberg J, Scharling H, Gadsboll N, Truelsen T, Jensen GB. Comparison of the impact of atrial fibrillation on the risk of stroke and cardiovascular death in women versus men (The Copenhagen City Heart Study). Am J Cardiol. 2004;94(7):889–94. https://doi.org/10.1016/j.amjcard.2004.06.023. CrossRefPubMed

53.

Ball J, Carrington MJ, Wood KA, Stewart S. Women versus men with chronic atrial fibrillation: insights from the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY). PLoS One. 2013;8(5):e65795. https://doi.org/10.1371/journal.pone.0065795. CrossRefPubMedPubMedCentral

54.

Avgil Tsadok M, Jackevicius CA, Rahme E, Humphries KH, Behlouli H, Pilote L. Sex differences in stroke risk among older patients with recently diagnosed atrial fibrillation. JAMA. 2012;307(18):1952–8. https://doi.org/10.1001/jama.2012.3490. CrossRefPubMed

55.

Nielsen PB, Skjøth F, Overvad TF, Larsen TB, Lip GYH. Female sex is a risk modifier rather than a risk factor for stroke in atrial fibrillation. Should We Use a CHA2DS2-VA Score Rather Than CHA2DS2-VASc?. Circulation. 2018;137(8):832–40. https://doi.org/10.1038/s41598-018-30946-0. CrossRefPubMed

56.

Hsu JC, Maddox TM, Kennedy K, Katz DF, Marzec LN, Lubitz SA, et al. Aspirin instead of oral anticoagulant prescription in atrial fibrillation patients at risk for stroke. J Am Coll Cardiol. 2016;67(25):2913–23. CrossRef

57.

Lip GY, Rushton-Smith SK, Goldhaber SZ, Fitzmaurice DA, Mantovani LG, Goto S, et al. Does sex affect anticoagulant use for stroke prevention in nonvalvular atrial fibrillation? The prospective global anticoagulant registry in the FIELD-atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2015;8(2 Suppl 1):S12–20. https://doi.org/10.1161/CIRCOUTCOMES.114.001556. CrossRefPubMed

58.

Pancholy SB, Sharma PS, Pancholy DS, Patel TM, Callans DJ, Marchlinski FE. Meta-analysis of gender differences in residual stroke risk and major bleeding in patients with nonvalvular atrial fibrillation treated with oral anticoagulants. Am J Cardiol. 2014;113(3):485–90. https://doi.org/10.1016/j.amjcard.2013.10.035. CrossRefPubMed

59.

Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;63(22):2438–88. CrossRef

60.

Chandrasekhar J, Dangas G, Mehran R. Valvular heart disease in women, differential remodeling, and response to new therapies. Curr Treat Options Cardiovasc Med. 2017;19(9):74. CrossRef

61.

Bach DS, Radeva JI, Birnbaum HG, Fournier A-A, Tuttle EG. Prevalence, referral patterns, testing, and surgery in aortic valve disease: leaving women and elderly patients behind? J Heart Valve Dis. 2007;16(4):362–9. PubMed

62.

Carabello BA, Paulus WJ. Aortic stenosis. Lancet (London, England). 2009;373(9667):956–66. https://doi.org/10.1016/j.jacc.2018.01.041. CrossRef

63.

Kulik A, Lam B-K, Rubens FD, Hendry PJ, Masters RG, Goldstein W, et al. Gender differences in the long-term outcomes after valve replacement surgery. Heart. 2009;95(4):318–26. https://doi.org/10.1136/hrt.2008.146688. CrossRefPubMed

64.

Fuchs C, Mascherbauer J, Rosenhek R, Pernicka E, Klaar U, Scholten C, et al. Gender differences in clinical presentation and surgical outcome of aortic stenosis. Heart. 2010;96(7):539–45. https://doi.org/10.1136/hrt.2009.186650. CrossRefPubMed

65.

•• Chaker Z, Badhwar V, Alqahtani F, Aljohani S, Zack CJ, Holmes DR, et al. Sex differences in the utilization and outcomes of surgical aortic valve replacement for severe aortic stenosis. J Am Heart Assoc. 2017;6(9):e006370. https://doi.org/10.1016/j.eucr.2018.07.023. Large-scale US database study of over 160, 000 patients assessing sex-related differences in clinical outcomes following AVR and highlighting distinctive risk profiles for men and women undergoing AVR. CrossRefPubMedPubMedCentral

66.

Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363(17):1597–607. https://doi.org/10.1056/NEJMoa1008232. CrossRefPubMed

67.

Mack MJ, Leon MB, Smith CR, Miller DC, Moses JW, Tuzcu EM, et al. 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015;385(9986):2477–84. https://doi.org/10.1016/S0140-6736(15)60308-7. CrossRefPubMed

68.

Culler SD, Cohen DJ, Brown PP, Kugelmass AD, Reynolds MR, Ambrose K, et al. Trends in aortic valve replacement procedures between 2009 and 2015: has transcatheter aortic valve replacement made a difference? Ann Thorac Surg. 2018;105(4):1137–43. https://doi.org/10.1016/j.athoracsur.2017.10.057. CrossRefPubMed

69.

• Azarbaijani Y, O’Callaghan K, Sanders WE, Wu C, Laschinger J, Marinac-Dabic D, et al. Sex-specific outcomes after transcatheter aortic valve replacement: a review of the literature. Cardiol Rev. 2018;26(2):73–81. https://doi.org/10.1097/CRD.0000000000000177. Literature review of existing sex-specific data on TAVR outcomes assessing efficacy and safety outcomes. Mortality, valve-related complications, cerebrovascular complications, and vascular complications are examined in a review of 23-published articles between 2010–2016. CrossRefPubMed

70.

McNeely C, Vassileva C. Mitral valve surgery in women: another target for eradicating sex inequality. Circ Cardiovasc Qual Outcomes. 2016;9(2 suppl 1):S94–S6. CrossRef

71.

Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, et al. Evidence-based guidelines for cardiovascular disease prevention in women. Circulation. 2004;109(5):672–93. https://doi.org/10.1161/01.CIR.0000114834.85476.81. CrossRefPubMed

72.

Vassileva CM, McNeely C, Mishkel G, Boley T, Markwell S, Hazelrigg S. Gender differences in long-term survival of Medicare beneficiaries undergoing mitral valve operations. Ann Thorac Surg. 2013;96(4):1367–73. https://doi.org/10.1016/j.athoracsur.2013.04.055. CrossRefPubMed

73.

Attizzani GF, Ohno Y, Capodanno D, Cannata S, Dipasqua F, Immé S, et al. Gender-related clinical and echocardiographic outcomes at 30-day and 12-month follow up after MitraClip implantation in the GRASP registry. Catheter Cardiovasc Interv. 2015;85(5):889–97. https://doi.org/10.1002/ccd.25715. CrossRefPubMed

74.

Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):e147–239. CrossRef

75.

Hsich EM, Piña IL. Heart failure in women: a need for prospective data. J Am Coll Cardiol. 2009;54(6):491–8. CrossRef

76.

Levy D, Kenchaiah S, Larson MG, Benjamin EJ, Kupka MJ, Ho KK, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397–402. https://doi.org/10.1056/NEJMoa020265. CrossRef

77.

Deswal A, Bozkurt B. Comparison of morbidity in women versus men with heart failure and preserved ejection fraction. Am J Cardiol. 2006;97(8):1228–31. https://doi.org/10.1016/j.amjcard.2005.11.042. CrossRefPubMed

78.

• Duca F, Zotter-Tufaro C, Kammerlander AA, Aschauer S, Binder C, Mascherbauer J, et al. Gender-related differences in heart failure with preserved ejection fraction. Sci Rep. 2018;8(1):1080. https://doi.org/10.1016/j.jcmg.2018.06.010. Prospective observational study assessing gender differences in a well-characterized HFpEF cohort of 302 patients assessing outcomes of cardiac death, cardiac death or HF hospitalization, and all-cause death CrossRefPubMedPubMedCentral

79.

Adams KF, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149(2):209–16. https://doi.org/10.1016/j.ahj.2004.08.005. CrossRef

80.

Merlo M, Pivetta A, Pinamonti B, Stolfo D, Zecchin M, Barbati G, et al. Long-term prognostic impact of therapeutic strategies in patients with idiopathic dilated cardiomyopathy: changing mortality over the last 30 years. Eur J Heart Fail. 2014;16(3):317–24. https://doi.org/10.1002/ejhf.16. CrossRefPubMed

81.

Shin JJ, Hamad E, Murthy S, Pina IL. Heart failure in women. Clin Cardiol. 2012;35(3):172–7. https://doi.org/10.1002/clc.21973. CrossRefPubMed

82.

Stevenson W, Tracy CM, Epstein AE, Darbar D, Dimarco JP, Dunbar SB, et al. 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines developed in collaboration with the American Association for Thoracic Surgery, Heart Failure Society of America, and Society of Thoracic Surgeons. J Thorac Cardiovasc Surg. 2012;144(6):e127–45. https://doi.org/10.1016/j.jtcvs.2012.08.032. CrossRef

83.

Lund LH, Edwards LB, Dipchand AI, Goldfarb S, Kucheryavaya AY, Levvey BJ, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-third adult heart transplantation report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016;35(10):1158–69. https://doi.org/10.1016/j.healun.2016.08.017. CrossRefPubMed

Titel: Disparities in Cardiac Care of Women: Current Data and Possible Solutions
Autoren:: MD, Pharm D Rosalyn O. Adigun
MD Amber N. Boler
MD Rekha Mankad
Publikationsdatum: 01.11.2018
DOI: https://doi.org/10.1007/s11936-018-0688-x
Verlag: Springer US
Zeitschrift: Current Treatment Options in Cardiovascular Medicine
Ausgabe 11/2018
Print ISSN: 1092-8464
Elektronische ISSN: 1534-3189

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