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Brain Structure and Function

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13.05.2019 | Original Article

Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum

verfasst von: Rhett A. Reichard, Kenneth P. Parsley, Suriya Subramanian, Daniel S. Zahm

Erschienen in: Brain Structure and Function | Ausgabe 5/2019

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Abstract

Previous studies have shown that infusion of a GABA_A receptor antagonist, such as bicuculline (bic), into the ventral (pallidum VP) of rats elicits vigorous ingestion in sated subjects and abnormal pivoting movements. Here, we assessed if the ingestive effects generalize to the lateral preoptic area (LPO) and tested both effects for modulation by dopamine receptor signaling. Groups of rats received injections of the dopamine D2 receptor antagonist, haloperidol (hal), the D1 antagonist, SCH-23390 (SCH), or vehicle (veh) followed by infusions of bic or veh into the VP or LPO. Ingestion effects were not observed following LPO bic infusions. Compulsive ingestion associated with VP activation was attenuated by hal, but not SCH. VP bic-elicited pivoting was attenuated by neither hal, nor SCH.

Austin MC, Kalivas PW (1989) Blockade of enkephalinergic and GABAergic mediated locomotion in the nucleus accumbens by muscimol in the ventral pallidum. Jpn J Pharmacol 50:487–490CrossRefPubMed

Austin MC, Kalivas PW (1990) Enkephalinergic and GABAergic modulation of motor activity in the ventral pallidum. J Pharmacol Exp Ther 252:1370–1377PubMed

Austin MC, Kalivas PW (1991) Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata. Brain Res 542:123–131CrossRefPubMed

Berntson GG (1973) Attack, grooming and threat elicited by stimulation of the pontine tegmentum in cats. Physiol Behav 11:81–87CrossRefPubMed

Blundell JE, Latham CJ (1980) Characterisation of adjustments to the structure of feeding behaviour following pharmacological treatment: effects of amphetamine and fenfluramine and the antagonism produced by pimozide and methergoline. Pharmacol Biochem Behav 12:717–722CrossRefPubMed

Bourne JA (2001) SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev 7:399–414CrossRefPubMed

Brown TG (1911) The intrinsic factors in the act of progression in the mammal. Proc R Soc Lond Ser B 84:308–319CrossRef

Chaurand JP, Vergnes M, Karli P (1974) Elicitation of aggressive behavior by electrical stimulation of ventral mesencephalic tegmentum in the rat (author's transl). Physiol Behav 12:771–778CrossRefPubMed

Christensen AV, Arnt J, Hyttel J, Larsen JJ, Svendsen O (1984) Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics. Life Sci 34:1529–1540CrossRefPubMed

Coburn PC, Striker EM (1978) Osmoregulatory thirst in rats after lateral preoptic lesions. J Comp Physiol 92:350–361

Covelo IR, Patel ZI, Luviano JA, Stratford TR, Wirtshafter D (2014) Manipulation of GABA in the ventral pallidum, but not the nucleus accumbens, induces intense, preferential, fat consumption in rats. Behav Brain Res 270:316–325CrossRefPubMed

Hall H, Kohler C, Gawell L (1985) Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain. Eur J Pharmacol 111:191–199CrossRefPubMed

Heimer L, Wilson RD (1975) The subcortical projections of allocortex: similarities in the neuronal associations of the hippocampus, the piriform cortex and the neocortex. In: Santini M (ed) Golgi centennial symposium proceedings. Raven Press, New York, pp 173–193

Inui T, Shimura T (2014) Delta-opioid receptor blockade in the ventral pallidum increases perceived palatability and consumption of saccharin solution in rats. Behav Brain Res 269:20–27CrossRefPubMed

Kelley AE, Bless EP, Swanson CJ (1996) Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats. J Pharmacol Exp Ther 278:1499–1507PubMed

Kelley AE, Baldo BA, Pratt WE, Will MJ (2005) Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86:773–795CrossRefPubMed

Kitamura M, Ikeda H, Koshikawa N, Cools AR (2001) GABA A agents injected into the ventral pallidum differentially affect dopaminergic pivoting and cholinergic circling elicited from the shell of the nucleus accumbens. Neuroscience 104:117–127CrossRefPubMed

Kupchik YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nat Neurosci 18:1230–1232CrossRefPubMedPubMedCentral

Leslie CA, Bennett JP Jr (1987) Striatal D1- and D2-dopamine receptor sites are separately detectable in vivo. Brain Res 415:90–97CrossRefPubMed

Leslie CA, Bennett JP Jr (1987) [3H] Spiperone binds selectively to rat striatal D2 dopamine receptors in vivo: a kinetic and pharmacological analysis. Brain Res 407:253–262CrossRefPubMed

Lovick TA, Zbrozyna AW (1975) Classical conditioning of the corneal reflex in the chronic decerebrate rat. Brain Res 89:337–340CrossRefPubMed

Lu XY, Ghasemzadeh MB, Kalivas PW (1998) Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens. Neuroscience 82:767–780CrossRefPubMed

Magoun HW, Atlas D, Ingersoll EH, Ranson SW (1937) Associated facial, vocal and respiratory components of emotional expression: an experimental study. J Neurol Psychopathol 17:241–255CrossRefPubMedPubMedCentral

Micco DJ (1974) Complex behaviors elicited by stimulation of the dorsal pontine tegmentum in rats. Brain Res 75:172–176CrossRefPubMed

Mogenson GJ, Nielsen MA (1983) Evidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity. Brain Res Bull 11:309–314CrossRefPubMed

Mogenson GJ, Wu M, Jones DL (1980) Locomotor activity elicited by injections of picrotoxin into the ventral tegmental area is attenuated by injections of GABA into the globus pallidus. Brain Res 191:569–571CrossRefPubMed

Norgren R, Hajnal A, Mungarndee SS (2006) Gustatory reward and the nucleus accumbens. Physiol Behav 89:531–535CrossRefPubMedPubMedCentral

Reichard RA, Parsley KP, Subramanian S, Stevenson HS, Schwartz ZM, SuraT Zahm DS (2019) The lateral preoptic area and ventral pallidum embolden behavior. Brain Struct Funct 224:1245–1265CrossRefPubMed

Reynolds SM, Geisler S, Berod A, Zahm DS (2006) Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Eur J Neurosci 24:188–196CrossRefPubMed

Robertson GS, Jian M (1995) D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain. Neuroscience 64:1019–1034CrossRefPubMed

Root DH, Melendez RI, Zaborszky L, Napier TC (2015) The ventral pallidum: subregion-specific functional anatomy and roles in motivated behaviors. Prog Neurobiol 130:29–70CrossRefPubMedPubMedCentral

Saad WA, Luiz AC, De Arruda Camargo LA, Renzi A, Manani JV (1996) The lateral preoptic area plays a dual role in the regulation of thirst in the rat. Brain Res Bull 39:171–176CrossRefPubMed

Sanghvi IS, Singer G, Friedman E, Gershon S (1975) Anorexigenic effects of d-amphetamine and l-DOPA in the rat. Pharmacol Biochem Behav 3:81–86CrossRefPubMed

Sheard MH, Flynn JP (1967) Facilitation of attack behavior by stimulation of the midbrain of cats. Brain Res 4:324–333CrossRefPubMed

Sherrington CS (1910) Flexion-reflex of the limb, crossed extension reflex and the stepping reflex and standing. J Physiol 40:28–121CrossRefPubMedPubMedCentral

Shreve PE, Uretsky NJ (1988) Effect of GABAergic transmission in the subpallidal region on the hypermotility response to the administration of excitatory amino acids and picrotoxin into the nucleus accumbens. Neuropharmacology 27:1271–1277CrossRefPubMed

Smith KS, Berridge KC (2005) The ventral pallidum and hedonic reward: neurochemical maps of sucrose “liking” and food intake. J Neurosci 25:8637–8649CrossRefPubMed

Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347:146–151CrossRefPubMed

Stratford TR, Wirtshafter D (2012) Lateral hypothalamic involvement in feeding elicited from the ventral pallidum. Eur J Neurosci 37:648–653CrossRefPubMedPubMedCentral

Stratford TR, Kelley AE, Simansky KJ (1999) Blockade of GABA(A) receptors in the medial ventral pallidum elicits feeding in satiated rats. Brain Res 825:199–203CrossRefPubMed

Subramanian S, Reichard RA, Stevenson HS, Schwartz ZM, Parsley KP, Zahm DS (2018) Lateral preoptic and ventral pallidal roles in locomotion and other movements. Brain Struct Funct 223:2907–2924CrossRefPubMedPubMedCentral

Waldbillig RJ (1975) Attack, eating, drinking, and gnawing elicited by electrical stimulation of rat mesencephalon and pons. J Comp Physiol Psychol 89:200–212CrossRefPubMed

Winn P, Williams SF, Herberg LJ (1982) Feeding stimulated by very low doses of d-amphetamine administered systemically or by microinjection into the striatum. Psychopharmacology (Berl) 78:336–341CrossRef

Wise RA (1974) Lateral hypothalamic electrical stimulation: does it make animals 'hungry'? Brain Res 67:187–209CrossRefPubMed

Woods JW (1964) Behavior of chronic decerebrate rats. J Neurophysiol 27:635–644CrossRefPubMed

Wyrwicka W, Doty RW (1966) Feeding induced in cats by electrical stimulation of the brain stem. Exp Brain Res 1:152–160CrossRefPubMed

Zahm DS, Heimer L (1990) Two transpallidal pathways originating in the rat nucleus accumbens. J Comp Neurol 302:437–446CrossRefPubMed

Zahm DS, Zaborszky L, Alones VE, Heimer L (1985) Evidence for the coexistence of glutamate decarboxylase and Met-enkephalin immunoreactivities in axon terminals of rat ventral pallidum. Brain Res 325:317–321CrossRefPubMed

Zahm DS, Schwartz ZM, Lavezzi HN, Yetinkoff L, Parsley KP (2014) Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct 219:511–526CrossRefPubMed

Titel: Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum
verfasst von: Rhett A. Reichard
Kenneth P. Parsley
Suriya Subramanian
Daniel S. Zahm
Publikationsdatum: 13.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 5/2019
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01879-9

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Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum

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