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Endocrine

Erschienen in:

18.07.2016 | Research Letter

Dissociation of ACTH and cortisol in septic and non-septic ICU patients

verfasst von: Hershel Raff, Nebiyu Biru, Neil Reisinger, David J. Kramer

Erschienen in: Endocrine | Ausgabe 1/2017

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Excerpt

The increase in circulating cortisol in septic intensive care unit (ICU) patients is not accompanied by increases in plasma adrenocorticotropic hormone (ACTH) [1]. This dissociation could be due to decreased metabolic clearance of cortisol and negative feedback inhibition of ACTH secretion [1]. The failure to maximally suppress ACTH secretion suggests an integration of activating central stress stimuli such as increased cytokines and inhibitory glucocorticoid negative feedback [2‐4]. …

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Titel: Dissociation of ACTH and cortisol in septic and non-septic ICU patients
verfasst von: Hershel Raff
Nebiyu Biru
Neil Reisinger
David J. Kramer
Publikationsdatum: 18.07.2016
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2017
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-016-1034-2

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