Background1
Methods
Results
Age group (years) | Period | Total | ||||||
---|---|---|---|---|---|---|---|---|
1998–2002 | 2003–2010 | 2011–2013 | ||||||
no
| %* | no
| %* | no
| %* | no
| % | |
<1 | 51 | 23.5 | 54 | 11.8 | 7 | 7.4 | 112 | 14.5 |
1 ˫ 2 | 36 | 16.6 | 49 | 10.7 | 3 | 3.1 | 88 | 11.4 |
2 ˫ 5 | 37 | 17.1 | 52 | 11.3 | 9 | 9.5 | 98 | 12.7 |
Subtotal (<5) | 124 | 57.1 | 155 | 33.8 | 19 | 20.0 | 298 | 38.7 |
5 ˫ 20 | 36 | 16.6 | 68 | 14.8 | 6 | 6.3 | 110 | 14.3 |
20˫ 60 | 45 | 20.7 | 164 | 35.7 | 47 | 49.5 | 256 | 32.2 |
≥60 | 12 | 5.5 | 72 | 15.7 | 23 | 24.2 | 107 | 13.9 |
Subtotal (≥5) | 93 | 42.9 | 304 | 66.2 | 76 | 80.0 | 473 | 61.3 |
Ignoreda
| 5 | 0.6 | 20 | 2.5 | 0 | 0.0 | 25 | 31 |
IPD | ||||||||
Meningitis | 124 | 55.8 | 195 | 40.7 | 45 | 47.4 | 364 | 45.7 |
Pneumonia | 79 | 35.6 | 240 | 50.1 | 39 | 41.0 | 358 | 45.0 |
Bacteremia/sepsis | 7 | 3.2 | 34 | 7.1 | 8 | 8.4 | 49 | 6.2 |
Otherb
| 12 | 5.4 | 10 | 2.1 | 3 | 3.2 | 25 | 3.1 |
Total | 222 | 100.0 | 479 | 100.0 | 95 | 100.0 | 796 | 100.0 |
Age group (years) | Diagnosis | Total | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Meningitis | Pneumonia | Bact/sepsis | Otherb
| |||||||
no
| %* | no
| %* | no
| %* | no
| %* | no
| % | |
<1 | 65 | 8.2 | 42 | 5.3 | 5 | 0.6 | 0 | 0.0 | 112 | 14.1 |
1 ˫ 2 | 29 | 3.6 | 54 | 6.8 | 4 | 0.5 | 1 | 0.1 | 88 | 11.0 |
2 ˫ 5 | 33 | 4.1 | 59 | 7.4 | 4 | 0.5 | 2 | 0.3 | 98 | 12.3 |
Subtotal < 5 | 127 | 16.0 | 155 | 19.5 | 13 | 1.6 | 3 | 0.4 | 298 | 37.4 |
5 ˫ 20 | 57 | 7.2 | 44 | 5.5 | 4 | 0.5 | 5 | 0.6 | 110 | 13.8 |
20 ˫ 60 | 127 | 16.0 | 101 | 12.7 | 19 | 2.4 | 9 | 1.1 | 256 | 32.2 |
≥60 | 42 | 5.3 | 50 | 6.3 | 9 | 1.1 | 6 | 0.8 | 107 | 2.1 |
Subtotal ≥ 5 | 226 | 28.4 | 195 | 24.5 | 32 | 4.0 | 20 | 2.5 | 473 | 59.4 |
Ignoreda
| 11 | 1.4 | 8 | 1.0 | 4 | 0.5 | 2 | 0.3 | 25 | 3.1 |
Total | 364 | 45.7 | 358 | 45.0 | 49 | 6.2 | 25 | 3.1 | 796 | 100.0 |
Serotypes | Periods | Total | ||||||
---|---|---|---|---|---|---|---|---|
1998–2002 | 2003–2010 | 2011–2013 | ||||||
no
| %* | no
| %* | no
| %* | no
| % | |
PCV7 | ||||||||
14 | 45 | 20.3 | 94 | 19.6 | 6 | 6.3 | 145 | 18.2 |
19F | 15 | 6.8 | 28 | 5.8 | 3 | 3.2 | 46 | 5.8 |
6B | 7 | 3.2 | 27 | 5.6 | 4 | 4.2 | 38 | 4.8 |
23F | 8 | 3.6 | 29 | 6.1 | 0 | 0.0 | 37 | 4.6 |
9V | 6 | 2.7 | 25 | 5.2 | 3 | 3.2 | 34 | 4.3 |
18C | 13 | 5.9 | 15 | 3.1 | 5 | 5.3 | 33 | 4.1 |
4 | 8 | 3.6 | 13 | 2.7 | 3 | 3.2 | 24 | 3.0 |
Total PCV7 | 102 | 45.9 | 231 | 48.2 | 24 | 25.3 | 357 | 44.8 |
Included PCV10 | ||||||||
1 | 12 | 5.4 | 31 | 6.5 | 0 | 0.0 | 43 | 5.4 |
7 F | 7 | 3.2 | 12 | 2.5 | 2 | 2.1 | 21 | 2.6 |
5 | 14 | 6.3 | 1 | 0.2 | 2 | 2.1 | 17 | 2.1 |
Total PCV10 | 33 | 14.9 | 44 | 9.2 | 4 | 4.2 | 81 | 10.2 |
Included PCV13 | ||||||||
3 | 14 | 6.3 | 42 | 8.8 | 17 | 17.9 | 73 | 9.2 |
6A | 13 | 5.9 | 20 | 4.2 | 6 | 6.3 | 39 | 4.9 |
19A | 13 | 5.9 | 18 | 3.8 | 2 | 2.1 | 33 | 4.1 |
Total PCV13 | 40 | 18.0 | 80 | 16.7 | 25 | 26.3 | 145 | 18.2 |
Non-vaccine | ||||||||
12F | 1 | 0.5 | 18 | 3.8 | 9 | 9.5 | 28 | 3.5 |
11A | 0 | 0.0 | 12 | 2.5 | 3 | 3.2 | 15 | 1.9 |
22F | 3 | 1.4 | 12 | 2.5 | 0 | 0.0 | 15 | 1.9 |
8 | 2 | 0.9 | 5 | 1.0 | 5 | 5.3 | 12 | 1.5 |
9N | 1 | 0.5 | 6 | 1.3 | 3 | 3.2 | 10 | 1.3 |
10A | 3 | 1.4 | 5 | 1.0 | 1 | 1.1 | 9 | 1.1 |
15C | 2 | 0.9 | 3 | 0.6 | 4 | 4.2 | 9 | 1.1 |
17F | 3 | 1.4 | 5 | 1.0 | 0 | 0.0 | 8 | 1.0 |
6C | 1 | 0.5 | 3 | 0.6 | 4 | 4.2 | 8 | 1.0 |
18A | 4 | 1.8 | 3 | 0.6 | 0 | 0.0 | 7 | 0.9 |
18B | 2 | 0.9 | 5 | 1.0 | 0 | 0.0 | 7 | 0.9 |
23B | 1 | 0.5 | 5 | 1.0 | 0 | 0.0 | 6 | 0.8 |
NT | 3 | 1.4 | 3 | 0.6 | 0 | 0.0 | 6 | 0.8 |
NR | 0 | 0.0 | 2 | 0.4 | 0 | 0.0 | 2 | 0.3 |
Othera
| 21 | 9.5 | 37 | 7.7 | 13 | 13.7 | 71 | 8.9 |
Total non- vaccine | 47 | 21.2 | 124 | 25.9 | 42 | 44.2 | 215 | 27.0 |
Total | 222 | 100.0 | 479 | 100.0 | 95 | 100.0 | 796 | 100.0 |
Serotypes | 1998–2002 n = 222 | Period | Total |
p value | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2003–2010 n = 479 | Subtotal n = 701 | 2011–2013 n = 95 |
n = 796 | ||||||||
no
| %* | no
| %* | no
| % | no
| %* | no
| % | ||
14 | 45 | 20.3 | 94 | 19.6 | 139 | 19.8 | 6 | 6.3 | 145 | 18.2 |
0.006
|
3 | 14 | 6.3 | 42 | 8.8 | 56 | 8.0 | 17 | 17.9 | 73 | 9.2 |
0.004
|
19F | 15 | 6.8 | 28 | 5.8 | 43 | 6.1 | 3 | 3.2 | 46 | 5.8 | 0.451 |
1 | 12 | 5.4 | 31 | 6.5 | 43 | 6.1 | 0 | 0.0 | 43 | 5.4 |
0.039
|
6A | 13 | 5.9 | 20 | 4.2 | 33 | 4.7 | 6 | 6.3 | 39 | 4.9 | 0.501 |
6B | 7 | 3.2 | 27 | 5.6 | 34 | 4.9 | 4 | 4.2 | 38 | 4.8 | 0.344 |
23F | 8 | 3.6 | 29 | 6.1 | 37 | 5.3 | 0 | 0.0 | 37 | 4.6 |
0.026
|
9V | 6 | 2.7 | 25 | 5.2 | 31 | 4.4 | 3 | 3.2 | 34 | 4.3 | 0.262 |
18C | 13 | 5.9 | 15 | 3.1 | 28 | 4.0 | 5 | 5.3 | 33 | 4.1 | 0.205 |
19A | 13 | 5.9 | 18 | 3.8 | 31 | 4.4 | 2 | 2.1 | 33 | 4.1 | 0.245 |
12F | 1 | 0.5 | 18 | 3.8 | 19 | 2.7 | 9 | 9.5 | 28 | 3.5 |
<0.001
|
4 | 8 | 3.6 | 13 | 2.7 | 21 | 3.0 | 3 | 3.2 | 24 | 3.0 | 0.811 |
7F | 7 | 3.2 | 12 | 2.5 | 19 | 2.7 | 2 | 2.1 | 21 | 2.6 | 0.832 |
5 | 14 | 6.3 | 1 | 0.2 | 15 | 2.1 | 2 | 2.1 | 17 | 2.1 |
<0.001
|
11A | 0 | 0.0 | 12 | 2.5 | 12 | 1.7 | 3 | 3.2 | 15 | 1.9 |
0.047
|
22F | 3 | 1.4 | 12 | 2.5 | 15 | 2.1 | 0 | 0.0 | 15 | 1.9 | 0.206 |
8 | 2 | 0.9 | 5 | 1.0 | 7 | 1.0 | 5 | 5.3 | 12 | 1.5 |
0.006
|
9N | 1 | 0.5 | 6 | 1.3 | 7 | 1.0 | 3 | 3.2 | 10 | 1.3 | 0.140 |
Serotype | Meningitis | Pneumonia | Bact/sepsis | Other | Total | |||||
---|---|---|---|---|---|---|---|---|---|---|
no
| %* | no
| %* | no
| %* | no
| %* | no
| %* | |
14 | 45 | 5.7 | 95 | 11.9 | 3 | 0.4 | 2 | 0.3 | 145 | 18.2 |
3 | 34 | 4.3 | 35 | 4.4 | 4 | 0.5 | 0 | 0.0 | 73 | 9.2 |
19F | 30 | 3.8 | 12 | 1.5 | 3 | 0.4 | 1 | 0.1 | 46 | 5.8 |
1 | 7 | 0.9 | 33 | 4.1 | 1 | 0.1 | 2 | 0.3 | 43 | 5.4 |
6A | 22 | 2.8 | 12 | 1.5 | 0 | 0.0 | 5 | 0.6 | 39 | 4.9 |
6B | 15 | 1.9 | 19 | 2.4 | 3 | 0.4 | 1 | 0.1 | 38 | 4.8 |
23F | 16 | 2.0 | 16 | 2.0 | 3 | 0.4 | 2 | 0.3 | 37 | 4.6 |
9V | 19 | 2.4 | 12 | 1.5 | 3 | 0.4 | 0 | 0.0 | 34 | 4.3 |
18C | 22 | 2.8 | 8 | 1.0 | 2 | 0.3 | 1 | 0.1 | 33 | 4.1 |
19A | 15 | 1.9 | 14 | 1.8 | 3 | 0.4 | 1 | 0.1 | 33 | 4.1 |
12F | 21 | 2.6 | 4 | 0.5 | 2 | 0.3 | 1 | 0.1 | 28 | 3.5 |
4 | 7 | 0.9 | 14 | 1.8 | 2 | 0.3 | 1 | 0.1 | 24 | 3.0 |
7F | 8 | 1.0 | 9 | 1.1 | 2 | 0.3 | 2 | 0.3 | 21 | 2.6 |
5 | 4 | 0.5 | 12 | 1.5 | 0 | 0.0 | 1 | 0.1 | 17 | 2.1 |
11A | 10 | 1.3 | 5 | 0.6 | 0 | 0.0 | 0 | 0.0 | 15 | 1.9 |
22F | 8 | 1.0 | 7 | 0.9 | 0 | 0.0 | 0 | 0.0 | 15 | 1.9 |
8 | 4 | 0.5 | 6 | 0.8 | 2 | 0.3 | 0 | 0.0 | 12 | 1.5 |
9N | 2 | 0.3 | 5 | 0.6 | 3 | 0.4 | 0 | 0.0 | 10 | 1.3 |
Other | 75 | 9.4 | 40 | 5.0 | 13 | 1.6 | 5 | 0.6 | 133 | 16.7 |
Total | 364 | 45.7 | 358 | 45.0 | 49 | 6.2 | 25 | 3.1 | 796 | 100.0 |
Serotype | Age group (years) | Total |
p value | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
< 1 n = 112 | 1˫ 2
n = 88 | 2˫5
n = 98 | Subtotal < 5 n = 298 | 5˫20
n = 110 | 20˫60
n = 256 | ≥60
n = 107 | Subtotal ≥ 5
n = 473 |
n = 771 | |||||||||||
no
| %* | no
| %* | no
| % | no
| %* | no
| %* | no
| %* | no
| %* | no
| % | no
| % | ||
14 | 37 | 33.0 | 36 | 40.9 | 38 | 38.8 |
111
|
37.2
| 8 | 7.3 | 15 | 5.9 | 7 | 6.5 |
30
|
6.3
| 141 | 18.3 |
<0.001
|
3 | 8 | 7.1 | 5 | 5.7 | 3 | 3.1 |
16
|
5.4
| 5 | 4.5 | 34 | 13.3 | 17 | 15.9 |
56
|
11.8
| 72 | 9.3 |
0.001
|
19F | 3 | 2.7 | 1 | 1.1 | 5 | 5.1 |
9
|
3.0
| 11 | 10.0 | 13 | 5.1 | 9 | 8.4 |
33
|
7.0
| 42 | 5.4 |
0.005
|
1 | 3 | 2.7 | 2 | 2.3 | 11 | 11.2 |
16
|
5.4
| 16 | 14.5 | 7 | 2.7 | 3 | 2.8 |
26
|
5.5
| 42 | 5.4 |
<0.001
|
6A | 10 | 8.9 | 3 | 3.4 | 8 | 8.2 |
21
|
7.0
| 7 | 6.4 | 9 | 3.5 | 2 | 1.9 |
18
|
3.8
| 39 | 5.1 |
0.079
|
6B | 6 | 5.4 | 10 | 11.4 | 3 | 3.1 |
19
|
6.4
| 0 | 0.0 | 13 | 5.1 | 5 | 4.7 |
18
|
3.8
| 37 | 4.8 |
0.012
|
23F | 4 | 3.6 | 5 | 5.7 | 2 | 2.0 |
11
|
3.7
| 6 | 5.5 | 12 | 4.7 | 7 | 6.5 |
25
|
5.3
| 36 | 4.7 | 0.696 |
9V | 4 | 3.6 | 4 | 4.5 | 3 | 3.1 |
11
|
3.7
| 5 | 4.5 | 8 | 3.1 | 10 | 9.3 |
23
|
4.9
| 34 | 4.4 | 0.167 |
18C | 6 | 5.4 | 4 | 4.5 | 6 | 6.1 |
16
|
5.4
| 8 | 7.3 | 5 | 2.0 | 3 | 2.8 |
16
|
3.4
| 32 | 4.2 | 0.174 |
19A | 10 | 8.9 | 3 | 3.4 | 3 | 3.1 |
16
|
5.4
| 2 | 1.8 | 9 | 3.5 | 6 | 5.6 |
17
|
3.6
| 33 | 4.3 | 0.123 |
12F | 1 | 0.9 | 1 | 1.1 | 1 | 1.0 |
3
|
1.0
| 4 | 3.6 | 15 | 5.9 | 4 | 3.7 |
23
|
4.9
| 26 | 3.4 |
0.074
|
4 | 0 | 0.0 | 0 | 0.0 | 2 | 2.0 |
2
|
0.7
| 2 | 1.8 | 16 | 6.2 | 4 | 3.7 |
22
|
4.7
| 24 | 3.1 |
0.007
|
7F | 2 | 1.8 | 2 | 2.3 | 1 | 1.0 |
5
|
1.7
| 3 | 2.7 | 9 | 3.5 | 3 | 2.8 |
15
|
3.2
| 20 | 2.6 | 0.825 |
5 | 2 | 1.8 | 3 | 3.4 | 1 | 1.0 |
6
|
2.0
| 3 | 2.7 | 6 | 2.3 | 0 | 0.0 |
9
|
1.9
| 15 | 1.9 | 0.531 |
11A | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
0
|
0.0
| 2 | 1.8 | 10 | 3.9 | 2 | 1.9 |
14
|
3.0
| 14 | 1.8 |
0.036
|
22F | 1 | 0.9 | 0 | 0.0 | 1 | 1.0 |
2
|
0.7
| 1 | 0.9 | 7 | 2.7 | 3 | 2.8 |
11
|
2.3
| 13 | 1.7 | 0.404 |
8 | 1 | 0.9 | 0 | 0.0 | 0 | 0.0 |
1
|
0.3
| 0 | 0.0 | 9 | 3.5 | 1 | 0.9 |
10
|
2.1
| 11 | 1.4 |
0.027
|
9N | 0 | 0.0 | 1 | 1.1 | 0 | 0.0 |
1
|
0.3
| 3 | 2.7 | 5 | 2.0 | 1 | 0.9 |
9
|
1.9
| 10 | 1.3 | 0.357 |