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European Radiology

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01.06.2014 | Musculoskeletal

Dixon-based MRI for assessment of muscle-fat content in phantoms, healthy volunteers and patients with achillodynia: comparison to visual assessment of calf muscle quality

verfasst von: Michael. A. Fischer, Christian W. A. Pfirrmann, Norman Espinosa, Dimitri A. Raptis, Florian M. Buck

Erschienen in: European Radiology | Ausgabe 6/2014

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Abstract

Objectives

To quantify the muscle fat-content (MFC) in phantoms, volunteers and patients with achillodynia using two-point Dixon-based magnetic resonance imaging (2pt-MRI_DIXON) in comparison to MR spectroscopy (MRS) and visual assessment of MFC.

Methods

Two-point Dixon-based MRI was used to measure the MFC of 15 phantoms containing 0-100 % fat-content and calf muscles in 30 patients (13 women; 57 ± 15 years) with achillodynia and in 20 volunteers (10 women; 30 ± 14 years) at 1.5 T. The accuracy of 2pt-MRI_DIXON in quantification of MFC was assessed in vitro using phantoms and in vivo using MRS as the standard of reference. Fat-fractions derived from 2pt-MRI_DIXON (FF_DIXON) and MRS (FF_MRS) were related to visual assessment of MFC (Goutallier grades 0–4) and Achilles-tendon quality (grade 0-4).

Results

Excellent linear correlation was demonstrated for FF_DIXON with phantoms and with FF_MRS in patients (p _c = 0.997/0.995; p < 0.001). FF_DIXON of the gastrocnemius muscle was significantly higher (p = 0.002) in patients (7.0 % ± 4.7 %) compared with volunteers (3.6 % ± 0.7 %), whereas visual-grading showed no difference between both groups (p > 0.05). FF_MRS and FF_DIXON were significantly higher in subjects with (>grade 1) structural damage of the Achilles-tendon (p = 0.01).

Conclusions

Two-point Dixon-based MRI allows for accurate quantification of MFC, outperforming visual assessment of calf muscle fat. Structural damage of the Achilles tendon is associated with a significantly higher MFC.

Key points

• Two-point Dixon-based MRI allows accurate quantification of muscular fat content (MFC).

• Quantitative analysis outperforms visual analysis in the detection of elevated MFC.

• Achillodynia results in an increased MFC of the gastrocnemius muscles.

• Structural damage of the Achilles tendon further increases the MFC.

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Titel: Dixon-based MRI for assessment of muscle-fat content in phantoms, healthy volunteers and patients with achillodynia: comparison to visual assessment of calf muscle quality
verfasst von: Michael. A. Fischer
Christian W. A. Pfirrmann
Norman Espinosa
Dimitri A. Raptis
Florian M. Buck
Publikationsdatum: 01.06.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3121-1

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Dixon-based MRI for assessment of muscle-fat content in phantoms, healthy volunteers and patients with achillodynia: comparison to visual assessment of calf muscle quality

Abstract

Objectives

Methods

Results

Conclusions

Key points

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Abstract

Objectives

Methods

Results

Conclusions

Key points

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