Background
Methods
Data collection
Data analysis
Results
Characteristics | Data (N = 594) |
---|---|
Age at baseline, years | 33.7 (11.7) |
Male sex | 276 (46%) |
Duration of back pain, yearsa | 7.1 (9.0) |
Self-reported ethnicity | |
White | 348 (59%) |
Asian | 214 (36%) |
Otherb | 32 (5%) |
IBP (according to experts’ definition) | 301/532 (57%) |
Good response to NSAIDsc | 274 (46%) |
Peripheral arthritisd | 197 (33%) |
Enthesitisd | 241 (41%) |
AAUd | 53 (9%) |
Dactylitisd | 23 (4%) |
Psoriasisd | 22 (4%) |
IBDd | 8 (1%) |
Positive family history according to ASAS definition | 135 (23%) |
Positive family history of AS | 87 (15%) |
Positive family history of AAU | 7 (1%) |
Positive family history of ReA | 8 (1%) |
Positive family history of IBD | 12 (2%) |
Positive family history of Psoriasis | 36 (6%) |
Total number of SpA-related diseases in first- or second-degree relatives | |
Number of patients with one disease | 120 (20%) |
Number of patients with two diseases | 15 (3%) |
Total number of family members with SpA-related diseases | |
Number of patients with one relative | 102 (17%) |
Number of patients with two relatives | 30 (5%) |
Number of patients with three relatives | 3 (1%) |
Total number of patients with positive family history in | |
First-degree relatives only | 100 (17%) |
Second-degree relatives only | 25 (4%) |
Both first- and second-degree relatives | 10 (2%) |
HLA-B27 positivity | 310 (52%) |
Elevated CRP/ESR | 185 (31%) |
Definite radiographic sacroiliitise | 119/593 (20%) |
Presence of active inflammation on MRI-SI | 189/424 (45%) |
Number of SpA featuresf,g | 2.4 (1.6) |
Clinical diagnosis of axSpAh | 368 (62%) |
HLA-B27+ (n = 310) | HLA-B27− (n = 284) | OR (95% CI) | p Value | |
---|---|---|---|---|
Positive family history according to ASAS definition | ||||
Stratified by self-reported ethnicity | ||||
White |
54
|
26
|
2.3 (1.4–3.9)
|
0.001
|
Asian |
38
|
14
|
3.1 (1.6–5.8)
|
0.001
|
Other ethnicitiesa | 2 | 1 | 2.3 (0.2–25.0) | 0.509 |
Stratified by degree of family relationship | ||||
First-degree relatives |
79
|
31
|
2.9 (1.8–4.5)
|
< 0.001
|
Only second-degree relatives | 15 | 10 | 1.7 (0.7–3.8) | 0.212 |
Positive family history of AS | ||||
Stratified by self-reported ethnicity | ||||
White |
37
|
6
|
7.1 (2.9–17.1)
|
< 0.001
|
Asian |
35
|
7
|
5.7 (2.5–13.2)
|
< 0.001
|
Other ethnicitiesa | 2 | 0 | n.a. | n.a. |
Stratified by degree of family relationship | ||||
First-degree relatives |
61
|
9
|
7.8 (3.8–16.0)
|
< 0.001
|
Only second-degree relatives |
13
|
4
|
3.7 (1.2–11.6)
|
0.023
|
Positive family history of AAU | ||||
Stratified by self-reported ethnicity | ||||
White | 4 | 0 | n.a. | n.a. |
Asian | 2 | 1 | 1.9 (0.2–20.7) | 0.613 |
Other ethnicitiesa | 0 | 0 | n.a. | n.a. |
Stratified by degree of family relationship | ||||
First-degree relatives | 5 | 1 | 4.7 (0.5–40.1) | 0.162 |
Only second-degree relatives | 1 | 0 | n.a. | n.a. |
Positive family history of ReA | ||||
Stratified by self-reported ethnicity | ||||
White | 2 | 2 | 0.9 (0.1–6.5) | 0.924 |
Asian | 1 | 3 | 0.3 (0.03–2.9) | 0.302 |
Other ethnicitiesa | 0 | 0 | n.a. | n.a. |
Stratified by degree of family relationship | ||||
First-degree relatives | 3 | 2 | 1.4 (0.2–8.2) | 0.735 |
Only second-degree relatives | 0 | 3 | n.a | n.a |
Positive family history of IBD | ||||
Stratified by self-reported ethnicity | ||||
White | 2 | 7 | 0.3 (0.05–1.2) | 0.089 |
Asian | 0 | 2 | n.a. | n.a. |
Other ethnicitiesa | 0 | 1 | n.a. | n.a. |
Stratified by degree of family relationship | ||||
First-degree relatives | 1 | 7 | 0.1 (0.02–1.0) | 0.054 |
Only second-degree relatives | 1 | 3 | 0.3 (0.03–2.9) | 0.294 |
Positive family history of psoriasis | ||||
Stratified by self-reported ethnicity | ||||
White | 16 | 15 | 1.0 (0.5–2.0) | 0.938 |
Asian | 2 | 2 | 0.9 (0.1–6.5) | 0.926 |
Other ethnicitiesa | 0 | 1 | n.a. | n.a. |
Stratified by degree of family relationship | ||||
First-degree relatives | 15 | 14 | 1.0 (0.5–2.1) | 0.949 |
Only second-degree relatives | 3 | 4 | 0.7 (0.2–3.1) | 0.620 |