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Sleep and Breathing

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19.10.2018 | Sleep Breathing Physiology and Disorders • Original Article

Do you have restless leg syndrome? I understood from your eyes

verfasst von: Hatice Kose Ozlece, Volkan Solmaz, Sadık Altan Özal, Yahya Çelik

Erschienen in: Sleep and Breathing | Ausgabe 2/2019

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Abstract

Purpose

According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness.

Methods

In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the “International RLS Study Group” criteria and 31 healthy subjects. All the patients and controls underwent routine ophthalmologic examination and had spectral-domain optical coherence tomography (OCT) performed. We compared the retinal thickness of the patients and control subjects.

Results

In the RLS group, foveal thickness was thinner then controls. Also, only inferior, superior, and temporal quadrant retina nerve fiber layer (RNFL) thickness were significantly thinner in the RLS group. The parafoveal ganglion cell complex (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and perifoveal superior nasal thickness was also significantly thinner in the patient group. Pearson correlation analyses showed that there were statistically significant negative correlations between disease duration and macular GCC and RNFL thickness. Negative correlations were also detected between parafoveal superior, temporal, inferior and nasal macular thickness, parafoveal superior nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC thickness and disease duration.

Conclusion

According to our results; most retinal layers are thinner in RLS patients, so it can be considered that OCT has a predictive value for progression of RLS.

Trotti LM (2017) Restless legs syndrome and sleep-related movement disorders. Continuum (Minneap Minn) 23(4, Sleep Neurology):1005–1016. https://doi.org/10.1212/CON.0000000000000488 CrossRef

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med 15(8):860–873. https://doi.org/10.1016/j.sleep.2014.03.025 CrossRefPubMed

Marin LF, Carvalho LBC, Prado LBF, Oliveira ASB, Prado GF (2017) Restless legs syndrome is highly prevalent in patients with post-polio syndrome. Sleep Med 37:147–150. https://doi.org/10.1016/j.sleep.2017.06.025 CrossRefPubMed

Chesson AL Jr, Wise M, Davila D, Johnson S, Littner M, Anderson WM, Hartse K, Rafecas J (1999) Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine report. Standards of Practice Committee of the American Academy of Sleep Medicine. Sleep 22(7):961–968CrossRefPubMed

Connor JR, Wang XS, Allen RP, Beard JL, Wiesinger JA, Felt BT, Earley CJ (2009) Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 132(Pt 9):2403–2412. https://doi.org/10.1093/brain/awp125 CrossRefPubMedPubMedCentral

Thorpy MJ (2012) Classification of sleep disorders. Neurotherapeutics 9(4):687–701. https://doi.org/10.1007/s13311-012-0145-6 CrossRefPubMedPubMedCentral

Turjanski N, Lees AJ, Brooks DJ (1999) Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 52(5):932–937. https://doi.org/10.1212/WNL.52.5.932 CrossRefPubMed

Bogan RK (2014) From bench to bedside: an overview of rotigotine for the treatment of restless legs syndrome. Clin Ther 36(3):436–455. https://doi.org/10.1016/j.clinthera.2014.01.021 CrossRefPubMed

Rohrer B, Stell WK (1995) Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry. Brain Res 695(2):110–116. https://doi.org/10.1016/0006-8993(95)00700-Z CrossRefPubMed

10.

Tian N, Xu HP, Wang P (2015) Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina. Eur J Neurosci 41(1):17–30. https://doi.org/10.1111/ejn.12783 CrossRefPubMed

11.

Dearry A, Edelman JL, Miller S, Burnside B (1990) Dopamine induces light-adaptive retinomotor movements in bullfrog cones via D2 receptors and in retinal pigment epithelium via D1 receptors. J Neurochem 54(4):1367–1378. https://doi.org/10.1111/j.1471-4159.1990.tb01971.x CrossRefPubMed

12.

Kafieh R, Rabbani H, Kermani S (2013) A review of algorithms for segmentation of optical coherence tomography from retina. J Med Signals Sens 3(1):45–60PubMedPubMedCentral

13.

Chorostecki J, Seraji-Bozorgzad N, Shah A, Bao F, Bao G, George E, Gorden V, Caon C, Frohman E, Bhatti MT, Khan O (2015) Characterization of retinal architecture in Parkinson’s disease. J Neurol Sci 355(1–2):44–48. https://doi.org/10.1016/j.jns.2015.05.007 CrossRefPubMed

14.

Bittersohl D, Stemplewitz B, Keseru M, Buhmann C, Richard G, Hassenstein A (2015) Detection of retinal changes in idiopathic Parkinson’s disease using high-resolution optical coherence tomography and Heidelberg retina tomography. Acta Ophthalmol 93(7):e578–e584. https://doi.org/10.1111/aos.12757 CrossRefPubMed

15.

Guler S, Nesrin Turan F (2015) Turkish version of the Johns Hopkins Restless Legs Syndrome Quality of Life Questionnaire (RLS-QoL): validity and reliability study. Qual Life Res Int J Qual Life Asp Treat Care Rehab 24(11):2789–2794. https://doi.org/10.1007/s11136-015-1003-x CrossRef

16.

Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, Trenkwalder C (2003) Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4(2):121–132. https://doi.org/10.1016/S1389-9457(02)00258-7 CrossRefPubMed

17.

Koskderelioglu A, Kusbeci T, Kusbeci OY, Gedizlioglu M (2016) Optic nerve head, retinal nerve fiber layer and macular thickness analysis in restless legs syndrome. Parkinsonism Relat Disord 31:110–115. https://doi.org/10.1016/j.parkreldis.2016.08.003 CrossRefPubMed

18.

Bara-Jimenez W, Aksu M, Graham B, Sato S, Hallett M (2000) Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology 54(8):1609–1616CrossRefPubMed

19.

Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A (2004) Retinal nerve fiber layer thinning in Parkinson disease. Vis Res 44(24):2793–2797. https://doi.org/10.1016/j.visres.2004.06.009 CrossRefPubMed

20.

Moschos MM, Tagaris G, Markopoulos I, Margetis I, Tsapakis S, Kanakis M, Koutsandrea C (2011) Morphologic changes and functional retinal impairment in patients with Parkinson disease without visual loss. Eur J Ophthalmol 21(1):24–29CrossRefPubMed

21.

Yu JG, Feng YF, Xiang Y, Huang JH, Savini G, Parisi V, Yang WJ, Fu XA (2014) Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis. PLoS One 9(1):e85718. https://doi.org/10.1371/journal.pone.0085718 CrossRefPubMedPubMedCentral

22.

Yavas GF, Yilmaz O, Kusbeci T, Ozturk F (2007) The effect of levodopa and dopamine agonists on optic nerve head in Parkinson disease. Eur J Ophthalmol 17(5):812–816CrossRefPubMed

23.

Carelli V, La Morgia C, Valentino ML, Barboni P, Ross-Cisneros FN, Sadun AA (2009) Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders. Biochim Biophys Acta 1787(5):518–528. https://doi.org/10.1016/j.bbabio.2009.02.024 CrossRefPubMed

24.

Mailankody P, Battu R, Khanna A, Lenka A, Yadav R, Pal PK (2015) Optical coherence tomography as a tool to evaluate retinal changes in Parkinson’s disease. Parkinsonism Relat Disord 21(10):1164–1169. https://doi.org/10.1016/j.parkreldis.2015.08.002 CrossRefPubMed

25.

Frederick JM, Rayborn ME, Laties AM, Lam DM, Hollyfield JG (1982) Dopaminergic neurons in the human retina. J Comp Neurol 210(1):65–79. https://doi.org/10.1002/cne.902100108 CrossRefPubMed

26.

Hirasawa H, Puopolo M, Raviola E (2009) Extrasynaptic release of GABA by retinal dopaminergic neurons. J Neurophysiol 102(1):146–158. https://doi.org/10.1152/jn.00130.2009 CrossRefPubMedPubMedCentral

27.

Djamgoz MB, Hankins MW, Hirano J, Archer SN (1997) Neurobiology of retinal dopamine in relation to degenerative states of the tissue. Vis Res 37(24):3509–3529. https://doi.org/10.1016/S0042-6989(97)00129-6 CrossRefPubMed

28.

Garcia-Martin E, Larrosa JM, Polo V, Satue M, Marques ML, Alarcia R, Seral M, Fuertes I, Otin S, Pablo LE (2014) Distribution of retinal layer atrophy in patients with Parkinson disease and association with disease severity and duration. Am J Ophthalmol 157(2):470–478 e472. https://doi.org/10.1016/j.ajo.2013.09.028 CrossRefPubMed

29.

Satue M, Obis J, Rodrigo MJ, Otin S, Fuertes MI, Vilades E, Gracia H, Ara JR, Alarcia R, Polo V, Larrosa JM, Pablo LE, Garcia-Martin E (2016) Optical coherence tomography as a biomarker for diagnosis, progression, and prognosis of neurodegenerative diseases. J Ophthalmol 2016:8503859. https://doi.org/10.1155/2016/8503859 CrossRefPubMedPubMedCentral

Titel: Do you have restless leg syndrome? I understood from your eyes
verfasst von: Hatice Kose Ozlece
Volkan Solmaz
Sadık Altan Özal
Yahya Çelik
Publikationsdatum: 19.10.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 2/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1740-5

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Do you have restless leg syndrome? I understood from your eyes

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Purpose

Methods

Results

Conclusion

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