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Digestive Diseases and Sciences

Erschienen in:

04.07.2017 | Correspondence

Does Metabolic Syndrome and Not the Inflammatory Load Predict Nonalcoholic Fatty Liver Disease Severity in Inflammatory Bowel Disease Patients?

verfasst von: Alessandro Sartini, Stefano Gitto, Erica Villa

Erschienen in: Digestive Diseases and Sciences | Ausgabe 9/2017

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Excerpt

We read with great interest the paper by Carr et al. [1] on the role of metabolic syndrome (MetS) and intestinal inflammation in the severity of nonalcoholic fatty liver disease (NAFLD) in patients with inflammatory bowel disease (IBD). They intercepted IBD patients with established NAFLD by using ICD-9 codes, finding that the majority of IBD patients (77%) had NAFLD in the absence of MetS, obesity, diabetes, and/or insulin resistance, but the presence of MetS predicted NAFLD severity. This suggests that IBD patients could develop NAFLD and fibrosis not only because of metabolic risk factors. …

Carr RM, Patel A, Bownik H, et al. Intestinal inflammation does not predict nonalcoholic fatty liver disease severity in inflammatory bowel disease patients. Dig Dis Sci. 2017;5:1354–1361. doi:10.1007/s10620-017-4495-0.CrossRef

Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010;15:1383–1395.CrossRef

Woods CP, Hazlehurst JM, Tomlinson JW. Glucocorticoids and nonalcoholic fatty liver disease. J Steroid Biochem Mol Biol. 2015;154:94–103.CrossRefPubMed

Bessissow T, Le NH, Rollet K, Afif W, Bitton A, Sebastiani G. Incidence and predictors of nonalcoholic fatty liver disease by serum biomarkers in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2016;8:1937–1944.CrossRef

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Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19:5A–36A.CrossRefPubMed

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Titel: Does Metabolic Syndrome and Not the Inflammatory Load Predict Nonalcoholic Fatty Liver Disease Severity in Inflammatory Bowel Disease Patients?
verfasst von: Alessandro Sartini
Stefano Gitto
Erica Villa
Publikationsdatum: 04.07.2017
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 9/2017
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-017-4665-0

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Does Metabolic Syndrome and Not the Inflammatory Load Predict Nonalcoholic Fatty Liver Disease Severity in Inflammatory Bowel Disease Patients?

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