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24.10.2017 | Review | Ausgabe 6/2017

Calcified Tissue International 6/2017

Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review

Zeitschrift:
Calcified Tissue International > Ausgabe 6/2017
Autoren:
Miljana Bacevic, Bozidar Brkovic, Adelin Albert, Eric Rompen, Regis P. Radermecker, France Lambert
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00223-017-0327-7) contains supplementary material, which is available to authorized users.

Abstract

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration.

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Zusatzmaterial
Supplementary material 1 (DOCX 23 kb) Appendix I Reason(s) for exclusion
223_2017_327_MOESM1_ESM.docx
Supplementary material 2 (DOCX 19 kb) Appendix II The selected studies
223_2017_327_MOESM2_ESM.docx
Supplementary material 3 (DOCX 19 kb) Appendix III The algorithm used for electronic search in PubMed
223_2017_327_MOESM3_ESM.docx
Literatur
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