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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Does vitamin D play a significant role in type 2 diabetes?

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Jayesh J Sheth, Ankna Shah, Frenny J Sheth, Sunil Trivedi, Mamta Lele, Navneet Shah, Premal Thakor, Rama Vaidya
Wichtige Hinweise

Competing interests

The authors declare no conflict of interest that could be perceived as prejudicing the impartiality of this research. None of the authors is involved in the financial support that might potentially bias his or her work.

Authors’ contributions

JS: Conceived and designed the experiments; agreed with manuscript results and conclusions; made critical revisions and approved final version; jointly developed the structure and arguments for the paper. AS: Analysed and interpreted the data, wrote the manuscript; agreed with manuscript results and conclusions. FS: Conceived and designed the experiments; agreed with manuscript results and conclusions; made critical revisions and approved final version. ST: Scrutinized the analysis and interpretation of the data, made critical revisions and approved final version. NS: Made critical revisions and approved final version. PT: Made critical revisions and approved final version. ML: Made critical revisions and approved final version. RV: Conceived and designed the experiments; made critical revisions and approved final version. All authors reviewed and approved of the final manuscript.

Abstract

Background

Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.

Methods

Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.

Results

Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).

Conclusion

Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.
Literatur
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