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Journal of Neural Transmission

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07.02.2018 | Neurology and Preclinical Neurological Studies - Review Article

Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia

verfasst von: Oscar Solís, Rosario Moratalla

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2018

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Abstract

The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l-3,4-dihydroxyphenylalanine (l-DOPA). However, disease progression and chronic treatment are associated with motor side effects such as l-DOPA-induced dyskinesia (LID). Dopamine receptor function is strongly associated with the mechanisms underlying LID. In fact, increased D1R signaling is associated with this motor side effect. Compelling evidence demonstrates that dopamine receptors in the striatum can form heteromeric complexes, and heteromerization can lead to changes in the functional and pharmacological properties of receptors compared to their monomeric subtypes. Currently, the most promising strategy for therapeutic intervention in dyskinesia originates from investigations of the D1R–D3R heteromers. Interestingly, there is a correlation between the expression of D1R–D3R heteromers and the development of LID. Moreover, D3R stimulation can potentiate the D1R signaling pathway. The aim of this review is to summarize current knowledge of the distinct roles of heteromeric dopaminergic receptor complexes in LID.

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Titel: Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
verfasst von: Oscar Solís
Rosario Moratalla
Publikationsdatum: 07.02.2018
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 8/2018
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1852-x

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